ES482472A1 - Procedimiento para la preparacion de isoquinoleinas. - Google Patents
Procedimiento para la preparacion de isoquinoleinas.Info
- Publication number
- ES482472A1 ES482472A1 ES482472A ES482472A ES482472A1 ES 482472 A1 ES482472 A1 ES 482472A1 ES 482472 A ES482472 A ES 482472A ES 482472 A ES482472 A ES 482472A ES 482472 A1 ES482472 A1 ES 482472A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- isoquinoline derivatives
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002537 isoquinolines Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 piperidino, piperazino Chemical group 0.000 abstract 2
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000006332 fluoro benzoyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Derivados 3-amino-4-fenil-isoquinoleínicos con efectos sobre el sistema nervioso central y 3- piperazinoisoquinoleínas con intenso efecto inhibidor sobre la aglomeración de trombocitos. Se han hallado ahora isoquinoleínas sustituidas con radicales básicos en posición 3, que poseen valiosas propiedades farmacológicas, especialmente propiedades psicótropas. Objeto de la invención es un procedimiento para la preparación de isoquinoleínas de la fórmula general **(Fórmula- 01)** donde: m significa uno ó dos R1 significa un grupo amino de la fórmula **(Fórmula-02)**, donde R4 y R5 son iguales o diferentes y significan hidrógeno o un radical alcohilo, saturado o insaturado, de cadena recta o ramificado, con 1 hasta 8 átomos de carbono, pudiendo los radicales alcohilo estar también sustituidos con un grupo hidroxi, alcoxi C1-C4 o con un grupo amino de la fórmula **(Fórmula-03), siendo R6 y R7 iguales o diferentes y representando hidrógeno o un radical alcohilo, de cadena recta o ramificado, con 1 hasta 6 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782818403 DE2818403A1 (de) | 1978-04-27 | 1978-04-27 | Neue isochinolinderivate und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES482472A1 true ES482472A1 (es) | 1980-04-01 |
Family
ID=6038097
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479820A Expired ES479820A1 (es) | 1978-04-27 | 1979-04-21 | Procedimiento para la preparacion de isoquinoleinas. |
| ES482472A Expired ES482472A1 (es) | 1978-04-27 | 1979-07-13 | Procedimiento para la preparacion de isoquinoleinas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479820A Expired ES479820A1 (es) | 1978-04-27 | 1979-04-21 | Procedimiento para la preparacion de isoquinoleinas. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4282222A (es) |
| EP (1) | EP0005232B1 (es) |
| JP (1) | JPS54148792A (es) |
| AU (1) | AU526681B2 (es) |
| CA (1) | CA1149809A (es) |
| DE (2) | DE2818403A1 (es) |
| DK (1) | DK170679A (es) |
| EG (1) | EG13857A (es) |
| ES (2) | ES479820A1 (es) |
| FI (1) | FI791343A7 (es) |
| GR (1) | GR71694B (es) |
| HU (1) | HU182028B (es) |
| IL (1) | IL57138A0 (es) |
| NO (1) | NO791391L (es) |
| PT (1) | PT69553A (es) |
| ZA (1) | ZA792018B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3034001A1 (de) * | 1980-09-10 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung |
| CA1255674A (en) * | 1983-09-29 | 1989-06-13 | Hendrik Timmerman | Quinazoline and isoquinoline derivatives with biocidal action |
| GB8328052D0 (en) * | 1983-10-20 | 1983-11-23 | Beecham Group Plc | Compounds |
| GB8426584D0 (en) * | 1984-10-19 | 1984-11-28 | Beecham Group Plc | Compounds |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
| US6346536B1 (en) | 1997-09-03 | 2002-02-12 | Guilford Pharmaceuticals Inc. | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same |
| WO1999011622A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Amino-substituted compounds, methods, and compositions for inhibiting parp activity |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US6395749B1 (en) | 1998-05-15 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, methods, and compositions for inhibiting PARP activity |
| US6387902B1 (en) | 1998-12-31 | 2002-05-14 | Guilford Pharmaceuticals, Inc. | Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP |
| AU2001275085A1 (en) | 2000-06-01 | 2001-12-11 | Guilford Pharmaceuticals Inc. | Methods, compounds and compositions for treating gout |
| GB0229281D0 (en) * | 2002-12-16 | 2003-01-22 | Novartis Ag | Organic compounds |
| JP5112297B2 (ja) * | 2005-05-20 | 2013-01-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なキノリン誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517005A (en) * | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
| DE2030675A1 (en) * | 1969-06-23 | 1971-02-11 | Arthur D Little, Inc , Cambridge, Mass (V St A) | 3-amino-4-phenyl-isoquinoline derivs |
| AU465390B2 (en) * | 1971-12-31 | 1975-09-10 | Ici Australia Limited | Isoquinolines |
| AT342057B (de) * | 1974-04-25 | 1978-03-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen |
-
1978
- 1978-04-27 DE DE19782818403 patent/DE2818403A1/de not_active Withdrawn
-
1979
- 1979-04-06 GR GR5883A patent/GR71694B/el unknown
- 1979-04-18 EG EG232/79A patent/EG13857A/xx active
- 1979-04-21 ES ES479820A patent/ES479820A1/es not_active Expired
- 1979-04-24 EP EP79101233A patent/EP0005232B1/de not_active Expired
- 1979-04-24 HU HU79HO2144A patent/HU182028B/hu unknown
- 1979-04-24 DE DE7979101233T patent/DE2963573D1/de not_active Expired
- 1979-04-25 DK DK170679A patent/DK170679A/da active IP Right Grant
- 1979-04-25 IL IL57138A patent/IL57138A0/xx unknown
- 1979-04-25 FI FI791343A patent/FI791343A7/fi not_active Application Discontinuation
- 1979-04-26 PT PT69553A patent/PT69553A/pt unknown
- 1979-04-26 AU AU46480/79A patent/AU526681B2/en not_active Ceased
- 1979-04-26 CA CA000326461A patent/CA1149809A/en not_active Expired
- 1979-04-26 NO NO791391A patent/NO791391L/no unknown
- 1979-04-27 JP JP5331679A patent/JPS54148792A/ja active Pending
- 1979-04-27 ZA ZA792018A patent/ZA792018B/xx unknown
- 1979-07-13 ES ES482472A patent/ES482472A1/es not_active Expired
- 1979-09-12 US US06/075,038 patent/US4282222A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0005232A1 (de) | 1979-11-14 |
| FI791343A7 (fi) | 1979-10-28 |
| DK170679A (da) | 1979-10-28 |
| HU182028B (en) | 1983-12-28 |
| AU526681B2 (en) | 1983-01-27 |
| EG13857A (en) | 1982-06-30 |
| ES479820A1 (es) | 1979-11-16 |
| AU4648079A (en) | 1979-11-22 |
| CA1149809A (en) | 1983-07-12 |
| IL57138A0 (en) | 1979-07-25 |
| JPS54148792A (en) | 1979-11-21 |
| DE2818403A1 (de) | 1979-11-08 |
| EP0005232B1 (de) | 1982-08-25 |
| PT69553A (de) | 1979-05-01 |
| NO791391L (no) | 1979-10-30 |
| DE2963573D1 (en) | 1982-10-21 |
| ZA792018B (en) | 1980-05-28 |
| GR71694B (es) | 1983-06-21 |
| US4282222A (en) | 1981-08-04 |
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