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ES481227A1 - Un procedimiento par preparar arilalquil y ariloxi-alquil- fosfonatos. - Google Patents

Un procedimiento par preparar arilalquil y ariloxi-alquil- fosfonatos.

Info

Publication number
ES481227A1
ES481227A1 ES481227A ES481227A ES481227A1 ES 481227 A1 ES481227 A1 ES 481227A1 ES 481227 A ES481227 A ES 481227A ES 481227 A ES481227 A ES 481227A ES 481227 A1 ES481227 A1 ES 481227A1
Authority
ES
Spain
Prior art keywords
formula
compound
preparing
lower alkoxy
arilalquil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481227A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES481227A1 publication Critical patent/ES481227A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Un procedimiento para preparar arilalquil y ariloxi- alquilfosfonatos que tienen la fórmula: **(Fórmula)** en donde Ar es fenilo o fenilo substituido mediante uno o dos substituyentes de halógeno, alcoxi inferior, de 1 a 4 átomos de carbono, hidroxi, alcanoiloxi de 1 a 4 átomos de carbono, carbo-alcoxi inferior de 2 a 4 átomos de carbono, carbamilo o carboxi; Y es (CH2)n o O(CH2)n, en donde n es un entero de 6 a 8; y R es alquilo de 1 a 6 átomos de carbono; caracterizado por calentar un compuesto que tiene la fórmula Ar-Y-X, en donde X es bromo o yodo, con un compuesto que tiene la fórmula P(OR)3 o con una sal de metal alcalino de un compuesto que tiene la fórmula HP(O)(OR)2; y, si se desea, hacer reaccionar un compuesto de la fórmula I obtenido, en donde Ar es un fenilo substituido mediante carbo-alcoxi inferior, con amoniaco o con un medio de hidrólisis alcalino para preparar un compuesto correspondiente en donde Ar es fenilo substituido mediante carbamilo o carboxi, respectivamente.
ES481227A 1978-06-05 1979-06-02 Un procedimiento par preparar arilalquil y ariloxi-alquil- fosfonatos. Expired ES481227A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/912,502 US4182759A (en) 1978-06-05 1978-06-05 Arylalkyl and aryloxyalkyl phosphonates and use as antiviral agents

Publications (1)

Publication Number Publication Date
ES481227A1 true ES481227A1 (es) 1980-09-01

Family

ID=25432033

Family Applications (2)

Application Number Title Priority Date Filing Date
ES481227A Expired ES481227A1 (es) 1978-06-05 1979-06-02 Un procedimiento par preparar arilalquil y ariloxi-alquil- fosfonatos.
ES489590A Granted ES489590A0 (es) 1978-06-05 1980-03-14 Un procedimiento para preparar arilalquil- y ariloxi-alquil-fosfonatos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES489590A Granted ES489590A0 (es) 1978-06-05 1980-03-14 Un procedimiento para preparar arilalquil- y ariloxi-alquil-fosfonatos

Country Status (27)

Country Link
US (1) US4182759A (es)
JP (1) JPS54160348A (es)
KR (1) KR840002462B1 (es)
AR (1) AR223343A1 (es)
AT (1) AT373897B (es)
AU (1) AU528266B2 (es)
BE (1) BE876680A (es)
CA (1) CA1108176A (es)
CH (1) CH641188A5 (es)
DE (1) DE2922054A1 (es)
DK (1) DK223579A (es)
ES (2) ES481227A1 (es)
FI (1) FI66009C (es)
FR (1) FR2428047A1 (es)
GB (1) GB2022589B (es)
IE (1) IE48334B1 (es)
IL (1) IL57300A (es)
IT (1) IT1203687B (es)
LU (1) LU81350A1 (es)
MX (1) MX6013E (es)
NL (1) NL7904265A (es)
NO (1) NO791770L (es)
NZ (1) NZ190460A (es)
PH (2) PH14734A (es)
PT (1) PT69693A (es)
SE (1) SE7904687L (es)
ZA (1) ZA792447B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2043073B (en) * 1979-02-13 1983-05-11 Symphar Sa Mono-and diphosphonate compounds
US4556520A (en) * 1982-10-08 1985-12-03 Zoecon Corporation 2-Nitro(cyano)phenyloxy(thio)alkyl phosphinates or phosphonates
DE4003054A1 (de) * 1990-02-02 1991-08-08 Hoechst Ag Verwendung von benzylphosphonsaeurederivaten zur behandlung von durch viren verursachte krankheiten
MX2012002368A (es) * 2009-08-27 2012-07-25 Epiphany Biosciences Inc Novedosos fosfonatos de nucleosido y analogos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2934507A (en) * 1954-06-18 1960-04-26 Monsanto Chemicals Polyvinyl chloride resins stabilized with mixtures of phosphonate esters, epoxy compounds and metallic salts of fatty acids
US3917718A (en) * 1972-06-22 1975-11-04 Sterling Drug Inc Cyclopropyl carbinol derivatives
US4031246A (en) * 1973-07-23 1977-06-21 Sterling Drug Inc. Aryloxyalkyl diketones

Also Published As

Publication number Publication date
SE7904687L (sv) 1979-12-06
LU81350A1 (fr) 1979-12-07
IE790945L (en) 1979-12-05
FI66009C (fi) 1984-08-10
ZA792447B (en) 1980-06-25
ATA401779A (de) 1983-07-15
IL57300A0 (en) 1979-09-30
FR2428047B1 (es) 1984-08-17
US4182759A (en) 1980-01-08
NZ190460A (en) 1981-07-13
AU4724979A (en) 1979-12-13
DE2922054A1 (de) 1979-12-06
IT7923000A0 (it) 1979-05-25
US4182759B1 (es) 1984-12-18
GB2022589B (en) 1982-10-13
FI791718A7 (fi) 1979-12-06
BE876680A (fr) 1979-11-30
IE48334B1 (en) 1984-12-12
PT69693A (en) 1979-06-01
FR2428047A1 (fr) 1980-01-04
JPS54160348A (en) 1979-12-19
IL57300A (en) 1983-06-15
FI66009B (fi) 1984-04-30
NO791770L (no) 1979-12-06
PH15469A (en) 1983-01-24
ES8103110A1 (es) 1981-02-16
NL7904265A (nl) 1979-12-07
GB2022589A (en) 1979-12-19
IT1203687B (it) 1989-02-15
CA1108176A (en) 1981-09-01
KR830001644A (ko) 1983-05-18
MX6013E (es) 1984-09-24
AR223343A1 (es) 1981-08-14
PH14734A (en) 1981-11-19
ES489590A0 (es) 1981-02-16
CH641188A5 (fr) 1984-02-15
DK223579A (da) 1979-12-06
AT373897B (de) 1984-02-27
AU528266B2 (en) 1983-04-21
KR840002462B1 (ko) 1984-12-29

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