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ES473787A1 - Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina. - Google Patents

Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina.

Info

Publication number
ES473787A1
ES473787A1 ES473787A ES473787A ES473787A1 ES 473787 A1 ES473787 A1 ES 473787A1 ES 473787 A ES473787 A ES 473787A ES 473787 A ES473787 A ES 473787A ES 473787 A1 ES473787 A1 ES 473787A1
Authority
ES
Spain
Prior art keywords
preparation
derivatives
formula
zolopirimidine
oxadia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES473787A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT74577A external-priority patent/AT351037B/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES473787A1 publication Critical patent/ES473787A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la preparación de derivados de oxadiazolopirimidina de la fórmula general (I) **(Fórmula)** en donde R representa un grupo de alquilo, alcoxialquilo, haloalquilo, aralquilo o arilo y R1 representa un grupo de dialquilamino, 4-alquil-1,2,5,6-tetrahidropiridin-1-ilo, piperidino, azabiciclononilo, azabiciclooctilo, 3-pirrolin-1-ilo, 3-hidroxi-1-piperidinilo ó 4-hidroxi-1-piperidinilo o Cuando R representa un grupo de haloalquilo, aralquilo o arilo, R1 puede representar también el grupo de 1,2,5,6-tetrahidropiridin-1-ilo, Y sus sales, cuyo procedimiento comprende trans-esterificar un compuesto de la fórmula I con un alcohol de la fórmula general R1-OH.
ES473787A 1977-02-04 1978-09-29 Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina. Expired ES473787A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT74577A AT351037B (de) 1977-02-04 1977-02-04 Verfahren zur herstellung von neuen oxadiazolo- pyrimidinderivaten und deren salzen
LU7778640A LU78640A1 (es) 1977-02-04 1977-12-05

Publications (1)

Publication Number Publication Date
ES473787A1 true ES473787A1 (es) 1979-05-16

Family

ID=25593802

Family Applications (2)

Application Number Title Priority Date Filing Date
ES466590A Expired ES466590A1 (es) 1977-02-04 1978-02-03 Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina.
ES473787A Expired ES473787A1 (es) 1977-02-04 1978-09-29 Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES466590A Expired ES466590A1 (es) 1977-02-04 1978-02-03 Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina.

Country Status (23)

Country Link
US (1) US4150131A (es)
JP (1) JPS6026115B2 (es)
AU (1) AU515104B2 (es)
BE (1) BE863609A (es)
CA (1) CA1096862A (es)
CH (1) CH638216A5 (es)
DE (1) DE2804519A1 (es)
DK (1) DK50778A (es)
ES (2) ES466590A1 (es)
FI (1) FI62310C (es)
FR (1) FR2383931A1 (es)
GB (2) GB1566673A (es)
GR (1) GR71603B (es)
HU (1) HU178012B (es)
IE (1) IE46320B1 (es)
IL (2) IL53926A (es)
IT (1) IT1092333B (es)
MC (1) MC1184A1 (es)
NL (1) NL7801289A (es)
NO (1) NO780395L (es)
NZ (1) NZ186335A (es)
PT (1) PT67615B (es)
SE (1) SE7801312L (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1103245A (en) * 1978-07-21 1981-06-16 Jean-Claude Muller Process for the manufacture of novel oxadiazolopyrimidine derivatives
NZ190915A (en) * 1978-07-31 1984-07-31 Hoffmann La Roche Oxadiazolotriazine derivatives and pharmaceutical compositions
US4307093A (en) * 1980-06-23 1981-12-22 The Upjohn Company Animal feed and process
US4316901A (en) * 1980-06-23 1982-02-23 The Upjohn Company Animal feed and process
DK148826C (da) * 1980-12-19 1986-03-24 Hoffmann La Roche Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade
US4411690A (en) * 1981-01-26 1983-10-25 E. I. Du Pont De Nemours & Co. Fused [1,2,4]oxadiazolylidenebenzenesulfonamides and their use as herbicides and plant growth regulants
CH649291A5 (de) * 1982-03-16 1985-05-15 Hoffmann La Roche Dicarbamate.
EP0187854A4 (en) * 1984-07-13 1987-01-22 Gail S Bazzano SUBSTITUTED PYRIMIDINE OXIDES USEFUL FOR PROMOTING HAIR GROWTH.
HU196061B (en) * 1986-07-10 1988-09-28 Richter Gedeon Vegyeszet Process for production of pirimidine-derivatives
LU86547A1 (fr) * 1986-08-07 1988-03-02 Oreal Suspension pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de la pyrimidine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3461461A (en) * 1965-11-01 1969-08-12 Upjohn Co 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines
DE2118261A1 (de) * 1971-04-15 1972-11-02 C.H. Boehringer Sohn, 6507 Ingelheim Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung
BE786028A (fr) * 1971-07-08 1973-01-08 Boehringer Sohn Ingelheim 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
BE790008A (fr) * 1971-10-15 1973-04-12 Fmc Corp Nouveaux composes herbicides
DE2210633C2 (de) * 1972-03-06 1983-09-22 Bayer Ag, 5090 Leverkusen Kondensierte Pyridinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2252122A1 (de) * 1972-10-24 1974-04-25 Hoechst Ag Oxazolo-chinazoline und verfahren zu ihrer herstellung
DE2253555A1 (de) * 1972-11-02 1974-05-09 Hoechst Ag Oxazolo-pyrimidine und verfahren zu ihrer herstellung
US3910928A (en) * 1974-04-26 1975-10-07 Upjohn Co 3-(Cyanimino)-propionitriles

Also Published As

Publication number Publication date
DE2804519C2 (es) 1990-06-13
ES466590A1 (es) 1978-10-01
PT67615A (en) 1978-03-01
SE7801312L (sv) 1978-08-05
GB1566672A (en) 1980-05-08
HU178012B (en) 1982-02-28
AU3285878A (en) 1979-08-09
NZ186335A (en) 1980-04-28
CH638216A5 (de) 1983-09-15
DE2804519A1 (de) 1978-08-10
NO780395L (no) 1978-08-07
FI780344A7 (fi) 1978-08-05
US4150131A (en) 1979-04-17
DK50778A (da) 1978-08-05
GB1566673A (en) 1980-05-08
FI62310B (fi) 1982-08-31
IE46320B1 (en) 1983-05-04
PT67615B (en) 1980-03-03
IL59713A0 (en) 1980-06-30
IL53926A0 (en) 1978-04-30
JPS6026115B2 (ja) 1985-06-21
MC1184A1 (fr) 1978-12-22
BE863609A (fr) 1978-08-03
NL7801289A (nl) 1978-08-08
FR2383931A1 (fr) 1978-10-13
JPS5398993A (en) 1978-08-29
FI62310C (fi) 1982-12-10
CA1096862A (en) 1981-03-03
IE780198L (en) 1978-08-04
IL53926A (en) 1980-12-31
GR71603B (es) 1983-06-17
AU515104B2 (en) 1981-03-19
FR2383931B1 (es) 1980-07-25
IT7819785A0 (it) 1978-01-30
IT1092333B (it) 1985-07-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102