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ES461796A1 - Un procedimiento para la preparacion de nuevos derivados de tiofeno. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de tiofeno.

Info

Publication number
ES461796A1
ES461796A1 ES461796A ES461796A ES461796A1 ES 461796 A1 ES461796 A1 ES 461796A1 ES 461796 A ES461796 A ES 461796A ES 461796 A ES461796 A ES 461796A ES 461796 A1 ES461796 A1 ES 461796A1
Authority
ES
Spain
Prior art keywords
thiophene derivatives
aralkyl
hydrogen
lower alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES461796A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES461796A1 publication Critical patent/ES461796A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de tiofeno de la fórmula general **(Fórmula)** en donde R1 es alquilo inferior; arilo o aralquilo R2 es hidrógeno, hidroxilo, alcoxilo inferior o amino; R3 y R4 que pueden ser iguales o distintos, son alquilo inferior, aralquilo, acilo o hidrógeno; y sus sales.
ES461796A 1976-08-23 1977-08-22 Un procedimiento para la preparacion de nuevos derivados de tiofeno. Expired ES461796A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71685476A 1976-08-23 1976-08-23
US71685376A 1976-08-23 1976-08-23
US82052177A 1977-08-01 1977-08-01

Publications (1)

Publication Number Publication Date
ES461796A1 true ES461796A1 (es) 1978-12-16

Family

ID=27418961

Family Applications (1)

Application Number Title Priority Date Filing Date
ES461796A Expired ES461796A1 (es) 1976-08-23 1977-08-22 Un procedimiento para la preparacion de nuevos derivados de tiofeno.

Country Status (21)

Country Link
JP (1) JPS5340755A (es)
AR (1) AR222453A1 (es)
AT (1) AT359486B (es)
AU (1) AU509956B2 (es)
BE (1) BE858012A (es)
CH (1) CH628628A5 (es)
DE (1) DE2737738C2 (es)
DK (1) DK150484C (es)
ES (1) ES461796A1 (es)
FI (1) FI66859C (es)
FR (1) FR2365566A1 (es)
GB (1) GB1587084A (es)
HU (1) HU179484B (es)
IE (1) IE45470B1 (es)
IL (1) IL52792A (es)
IT (1) IT1143757B (es)
LU (1) LU78003A1 (es)
MC (1) MC1156A1 (es)
NL (1) NL7709246A (es)
NO (1) NO148673C (es)
NZ (1) NZ184981A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6232765Y2 (es) * 1981-02-28 1987-08-21
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2162586C (en) 1993-05-13 2006-01-03 David J. Grainger Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
DE102004063191A1 (de) 2004-12-29 2006-07-13 Bayer Cropscience Ag Verfahren zur Herstellung von substituierten 2-Alkoxycarbonyl-3-aminothiophenen
CN103360290B (zh) * 2008-02-29 2015-04-01 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
AR130733A1 (es) 2022-10-14 2025-01-15 Adama Agan Ltd Proceso para la preparación de aminotiofeno sustituido

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2502421A (en) * 1944-08-28 1950-04-04 Parke Davis & Co Tetrahydrothiophenes
US2502424A (en) * 1944-12-23 1950-04-04 Parke Davis & Co 3-acylamino-4-carboalkoxy-2-omega-ralkylthiophenes
US2443598A (en) * 1944-12-23 1948-06-22 Parke Davis & Co 3-amino-4-carbethoxy-2-alkyl derivatives of thiophene
US2502423A (en) * 1944-12-23 1950-04-04 Parke Davis & Co 4-carbalkoxy-3-keto-2-substituted tetrahydrothiophene oximes

Also Published As

Publication number Publication date
MC1156A1 (fr) 1978-04-17
FI66859C (fi) 1984-12-10
IE45470L (en) 1978-02-23
DE2737738A1 (de) 1978-03-09
IL52792A0 (en) 1977-10-31
JPS5340755A (en) 1978-04-13
NO148673B (no) 1983-08-15
BE858012A (fr) 1978-02-22
DK150484C (da) 1987-10-05
LU78003A1 (es) 1978-09-14
NO772917L (no) 1978-02-24
AU509956B2 (en) 1980-06-05
IE45470B1 (en) 1982-09-08
AR222453A1 (es) 1981-05-29
FR2365566B1 (es) 1980-12-26
FI772494A7 (fi) 1978-02-24
DK372177A (da) 1978-02-24
IT1143757B (it) 1986-10-22
DE2737738C2 (de) 1987-01-29
NZ184981A (en) 1980-08-26
ATA607477A (de) 1980-04-15
NL7709246A (nl) 1978-02-27
GB1587084A (en) 1981-03-25
CH628628A5 (en) 1982-03-15
AU2809277A (en) 1979-03-01
IL52792A (en) 1981-06-29
FI66859B (fi) 1984-08-31
JPS6121235B2 (es) 1986-05-26
NO148673C (no) 1983-11-23
HU179484B (en) 1982-10-28
AT359486B (de) 1980-11-10
DK150484B (da) 1987-03-09
FR2365566A1 (fr) 1978-04-21

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