ES478115A1 - New cephalosporin derivatives, their preparations and their pharmaceutical compositions. - Google Patents
New cephalosporin derivatives, their preparations and their pharmaceutical compositions.Info
- Publication number
- ES478115A1 ES478115A1 ES478115A ES478115A ES478115A1 ES 478115 A1 ES478115 A1 ES 478115A1 ES 478115 A ES478115 A ES 478115A ES 478115 A ES478115 A ES 478115A ES 478115 A1 ES478115 A1 ES 478115A1
- Authority
- ES
- Spain
- Prior art keywords
- salts
- acyl derivatives
- formula
- preparations
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Derivados acílicos. Más particularmente el invento se refiere a derivados acílicos, a un procedimiento para su preparación y a los preparados farmacéuticos que los contienen. Los derivados acílicos proporcionados por el presente invento son compuestos de la fórmula general **fórmula** Las sales de los compuestos de la fórmula I son sales de metal alcalino tal como la sal sódica y potásica, las amónica, sales alcalino térreas tal como la sal cálcica, sales con bases orgánicas tal como sales con aminas (por ejemplo sales con N-etil-piperidina, procaina, dibencilamina, N,N''-dibenciletiletilendiamina, alquilaminas o dialquilaminas) así como sales con aminoácidos (por ejemplo sales con araginina o lisina). Las sales pueden ser mono-sales o diales. La segunda formación de sal se produce en la forma enólica tautomérica del grupo tiracínico (b), siendo dicha forma acídica.acyl derivatives. More particularly, the invention relates to acyl derivatives, to a process for their preparation and to pharmaceutical preparations containing them. The acyl derivatives provided by the present invention are compounds of the general formula **formula** The salts of the compounds of formula I are alkali metal salts such as sodium and potassium salt, ammonium salts, alkaline earth salts such as calcium salt, salts with organic bases such as salts with amines (for example salts with N-ethyl-piperidine, procaine, dibenzylamine, N,N''-dibenzylethylethylenediamine, alkylamines or dialkylamines) as well as salts with amino acids (for example salts with araginine or lysine). The salts can be mono-salts or dials. The second salt formation occurs in the tautomeric enol form of the tyrazine group (b), said form being acidic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU77485 | 1977-06-03 | ||
| CH314278 | 1978-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES478115A1 true ES478115A1 (en) | 1979-06-01 |
Family
ID=25692293
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470442A Expired ES470442A1 (en) | 1977-06-03 | 1978-06-02 | ŸPROCEDURE FOR THE PREPARATION OF ACYLIC DERIVATIVESŸ |
| ES478115A Expired ES478115A1 (en) | 1977-06-03 | 1979-02-27 | New cephalosporin derivatives, their preparations and their pharmaceutical compositions. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470442A Expired ES470442A1 (en) | 1977-06-03 | 1978-06-02 | ŸPROCEDURE FOR THE PREPARATION OF ACYLIC DERIVATIVESŸ |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0000005B1 (en) |
| JP (1) | JPS5412394A (en) |
| AR (1) | AR225134A1 (en) |
| AT (2) | AT362501B (en) |
| AU (1) | AU518648B2 (en) |
| BR (1) | BR7803565A (en) |
| CA (1) | CA1114808A (en) |
| CU (1) | CU21118A (en) |
| DE (2) | DE2860248D1 (en) |
| DK (1) | DK246878A (en) |
| ES (2) | ES470442A1 (en) |
| FI (1) | FI781754A7 (en) |
| FR (1) | FR2393000A1 (en) |
| GB (1) | GB1599232A (en) |
| GR (1) | GR73554B (en) |
| HU (1) | HU182498B (en) |
| IE (1) | IE46903B1 (en) |
| IL (1) | IL54803A (en) |
| IT (1) | IT1098306B (en) |
| MC (1) | MC1195A1 (en) |
| NL (1) | NL7805715A (en) |
| NO (1) | NO781934L (en) |
| NZ (1) | NZ187392A (en) |
| PH (1) | PH14653A (en) |
| PT (1) | PT68134A (en) |
| SE (1) | SE7806465L (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
| FR2432521A1 (en) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS |
| MC1259A1 (en) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | ACYL DERIVATIVES |
| NO782998L (en) * | 1978-07-19 | 1980-01-22 | Hoffmann La Roche | CEPHALOSPORINESTERS AND EATERS. |
| US4472574A (en) * | 1981-05-22 | 1984-09-18 | Hoffman-La Roche Inc. | Process for the manufacture of a cephem carboxylic acid derivative |
| US4698338A (en) * | 1986-02-19 | 1987-10-06 | Eli Lilly And Company | 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| CH609989A5 (en) * | 1974-06-21 | 1979-03-30 | Hoffmann La Roche | Process for the preparation of acyl derivatives |
| CA1100129A (en) * | 1974-08-02 | 1981-04-28 | William H.W. Lunn | Cephalosporin compounds |
| GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
| GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
| GB1596278A (en) * | 1976-11-30 | 1981-08-26 | Glaxo Operations Ltd | 7-(-oxyimino-acetamino)cephalosporin derivatives |
-
1978
- 1978-05-25 NL NL7805715A patent/NL7805715A/en not_active Application Discontinuation
- 1978-05-25 GB GB22499/78A patent/GB1599232A/en not_active Expired
- 1978-05-26 MC MC781305A patent/MC1195A1/en unknown
- 1978-05-26 NZ NZ187392A patent/NZ187392A/en unknown
- 1978-05-26 IE IE1056/78A patent/IE46903B1/en unknown
- 1978-05-29 AU AU36588/78A patent/AU518648B2/en not_active Expired
- 1978-05-29 IL IL54803A patent/IL54803A/en unknown
- 1978-05-31 HU HU78HO2077A patent/HU182498B/en unknown
- 1978-06-01 DE DE7878100078T patent/DE2860248D1/en not_active Expired
- 1978-06-01 EP EP78100078A patent/EP0000005B1/en not_active Expired
- 1978-06-01 JP JP6501078A patent/JPS5412394A/en active Pending
- 1978-06-01 FR FR7816468A patent/FR2393000A1/en active Granted
- 1978-06-01 FI FI781754A patent/FI781754A7/en not_active Application Discontinuation
- 1978-06-01 SE SE7806465A patent/SE7806465L/en unknown
- 1978-06-01 DE DE19782824065 patent/DE2824065A1/en not_active Withdrawn
- 1978-06-01 GR GR56409A patent/GR73554B/el unknown
- 1978-06-02 ES ES470442A patent/ES470442A1/en not_active Expired
- 1978-06-02 DK DK246878A patent/DK246878A/en not_active Application Discontinuation
- 1978-06-02 NO NO781934A patent/NO781934L/en unknown
- 1978-06-02 PH PH21225A patent/PH14653A/en unknown
- 1978-06-02 PT PT68134A patent/PT68134A/en unknown
- 1978-06-02 BR BR787803565A patent/BR7803565A/en unknown
- 1978-06-02 AT AT403578A patent/AT362501B/en not_active IP Right Cessation
- 1978-06-02 AR AR272437A patent/AR225134A1/en active
- 1978-06-02 CA CA304,644A patent/CA1114808A/en not_active Expired
- 1978-06-02 IT IT24165/78A patent/IT1098306B/en active
- 1978-07-03 CU CU7834929A patent/CU21118A/en unknown
-
1979
- 1979-02-27 ES ES478115A patent/ES478115A1/en not_active Expired
-
1980
- 1980-07-02 AT AT0345980A patent/AT365197B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT7824165A0 (en) | 1978-06-02 |
| NL7805715A (en) | 1978-12-05 |
| DE2824065A1 (en) | 1978-12-14 |
| GB1599232A (en) | 1981-09-30 |
| AT362501B (en) | 1981-05-25 |
| EP0000005B1 (en) | 1980-10-29 |
| ATA403578A (en) | 1980-10-15 |
| FI781754A7 (en) | 1978-12-04 |
| CA1114808A (en) | 1981-12-22 |
| IE46903B1 (en) | 1983-11-02 |
| AU518648B2 (en) | 1981-10-15 |
| PT68134A (en) | 1978-07-01 |
| HU182498B (en) | 1984-01-30 |
| MC1195A1 (en) | 1979-02-23 |
| GR73554B (en) | 1984-03-14 |
| SE7806465L (en) | 1978-12-04 |
| NZ187392A (en) | 1984-05-31 |
| AU3658878A (en) | 1979-12-06 |
| ES470442A1 (en) | 1979-10-01 |
| NO781934L (en) | 1978-12-05 |
| IE781056L (en) | 1978-12-03 |
| DK246878A (en) | 1978-12-04 |
| IL54803A0 (en) | 1978-07-31 |
| PH14653A (en) | 1981-10-14 |
| DE2860248D1 (en) | 1981-01-29 |
| BR7803565A (en) | 1979-02-20 |
| IT1098306B (en) | 1985-09-07 |
| CU21118A (en) | 1983-04-06 |
| FR2393000B1 (en) | 1982-10-29 |
| JPS5412394A (en) | 1979-01-30 |
| ATA345980A (en) | 1981-05-15 |
| AR225134A1 (en) | 1982-02-26 |
| AT365197B (en) | 1981-12-28 |
| EP0000005A1 (en) | 1978-12-20 |
| FR2393000A1 (en) | 1978-12-29 |
| IL54803A (en) | 1982-01-31 |
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