ES477164A1 - Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina. - Google Patents
Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina.Info
- Publication number
- ES477164A1 ES477164A1 ES477164A ES477164A ES477164A1 ES 477164 A1 ES477164 A1 ES 477164A1 ES 477164 A ES477164 A ES 477164A ES 477164 A ES477164 A ES 477164A ES 477164 A1 ES477164 A1 ES 477164A1
- Authority
- ES
- Spain
- Prior art keywords
- diazepine
- diazepine derivatives
- duodenyl
- thieno
- gastro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 title 1
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 abstract 1
- SYRJZPZXPUZRNY-UHFFFAOYSA-N C[S+](C(C1)=O)C2=C1CN(C1=CC=CC=C1)N(C1CC1)C=C2 Chemical compound C[S+](C(C1)=O)C2=C1CN(C1=CC=CC=C1)N(C1CC1)C=C2 SYRJZPZXPUZRNY-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento de preparación de 6-ciclopropil-1,3-dihidro-5-fenil-2-oxo-2H-tieno {2,3-e} diazapina, caracterizado por: (a) hacer reaccionar ciclopropilmetilcetona con benzoilacetonitrilo en benceno, en presencia de ácido acético, para formar 2-benzoil-3- ciclopropil-crotonitrilo; (b) tratar este último compuesto con azufre en etanol, en presencia de trietilamina, para obtener 2-amino-3-benzoil-4-ciclopropil-tiofeno; (c) hacer reaccionar bromuro del ácido bromoacético con este último compuesto, en éter y en presencia de piridina, a la temperatura ambiente, para formar 3-benzoil-2-alfa- bromoacetamido-4-ciclopropil-tiofeno; (d) aminar este último con amoniaco en tetrahidrofurano para obtener 2-alfa-aminoacetamido-3-benzoiil-4-cicloporpil-tiofeno y (e) ciclar este último mediante calentamiento a reflujo en tolueno, en presencia de ácido acético, para obtener 6-ciclopropil-1,3-dihidro-5-fenil-2-oxo-2H-tieno {2,3-e} diazapina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1358777 | 1977-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES477164A1 true ES477164A1 (es) | 1979-10-16 |
Family
ID=10025687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468382A Expired ES468382A1 (es) | 1977-03-31 | 1978-03-30 | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihidro-1-metil-5-fenil-2-oxo-2h-tieno(2,3-e)diazepina |
| ES477164A Expired ES477164A1 (es) | 1977-03-31 | 1979-01-25 | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468382A Expired ES468382A1 (es) | 1977-03-31 | 1978-03-30 | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihidro-1-metil-5-fenil-2-oxo-2h-tieno(2,3-e)diazepina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4156009A (es) |
| JP (1) | JPS53121791A (es) |
| AR (1) | AR215171A1 (es) |
| AU (1) | AU3495678A (es) |
| BE (1) | BE865278A (es) |
| DD (2) | DD143777A5 (es) |
| DE (1) | DE2813996A1 (es) |
| DK (1) | DK135478A (es) |
| ES (2) | ES468382A1 (es) |
| FR (1) | FR2385721A1 (es) |
| GR (1) | GR62853B (es) |
| NL (1) | NL7803431A (es) |
| NO (1) | NO781102L (es) |
| PT (1) | PT67813A (es) |
| SE (1) | SE7803604L (es) |
| SU (1) | SU715027A3 (es) |
| ZA (1) | ZA781694B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0225554D0 (en) * | 2002-11-01 | 2002-12-11 | Syngenta Participations Ag | Chemical compounds |
| WO2025212920A1 (en) | 2024-04-03 | 2025-10-09 | Children's Hospital Medical Center | Multi-zonal liver organoids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1256548A (es) * | 1968-12-10 | 1971-12-08 | ||
| CA927388A (en) * | 1970-02-17 | 1973-05-29 | Nakanishi Michio | Thieno (2,3-e)(1,4)diazepin-2-ones |
| US3806512A (en) * | 1970-09-03 | 1974-04-23 | Yoshitomi Pharmaceutical | 2-amino-3-pyridylcarbonylthiophene compounds |
| FI53214C (es) * | 1970-11-16 | 1978-03-10 | Sumitomo Chemical Co | |
| US3872089A (en) * | 1971-05-14 | 1975-03-18 | Hoffmann La Roche | Substituted thienodiazepines |
| GB1345998A (en) * | 1971-05-31 | 1974-02-06 | Yoshitomi Pharmaceutical | Thienodiazepine compounds and pharmaceutical compositions containining them |
| JPS5750794B2 (es) * | 1973-02-03 | 1982-10-28 | ||
| JPS5729472B2 (es) * | 1974-05-02 | 1982-06-23 |
-
1978
- 1978-03-16 FR FR7807697A patent/FR2385721A1/fr not_active Withdrawn
- 1978-03-23 ZA ZA00781694A patent/ZA781694B/xx unknown
- 1978-03-23 PT PT67813A patent/PT67813A/pt unknown
- 1978-03-23 GR GR55787A patent/GR62853B/el unknown
- 1978-03-24 BE BE2056799A patent/BE865278A/xx unknown
- 1978-03-27 JP JP3525278A patent/JPS53121791A/ja active Pending
- 1978-03-27 AR AR271535A patent/AR215171A1/es active
- 1978-03-27 US US05/890,410 patent/US4156009A/en not_active Expired - Lifetime
- 1978-03-28 DK DK135478A patent/DK135478A/da unknown
- 1978-03-29 DD DD78213659A patent/DD143777A5/de unknown
- 1978-03-29 DD DD78204460A patent/DD137108A5/xx unknown
- 1978-03-30 SE SE7803604A patent/SE7803604L/xx unknown
- 1978-03-30 ES ES468382A patent/ES468382A1/es not_active Expired
- 1978-03-30 SU SU782594351A patent/SU715027A3/ru active
- 1978-03-30 NO NO781102A patent/NO781102L/no unknown
- 1978-03-31 NL NL7803431A patent/NL7803431A/xx not_active Application Discontinuation
- 1978-03-31 DE DE19782813996 patent/DE2813996A1/de active Pending
- 1978-04-11 AU AU34956/78A patent/AU3495678A/en active Pending
-
1979
- 1979-01-25 ES ES477164A patent/ES477164A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO781102L (no) | 1978-10-03 |
| DE2813996A1 (de) | 1978-10-05 |
| ES468382A1 (es) | 1979-10-01 |
| DK135478A (da) | 1978-10-01 |
| SE7803604L (sv) | 1978-10-01 |
| AR215171A1 (es) | 1979-09-14 |
| GR62853B (en) | 1979-06-20 |
| SU715027A3 (ru) | 1980-02-05 |
| AU3495678A (en) | 1979-10-18 |
| US4156009A (en) | 1979-05-22 |
| PT67813A (fr) | 1978-04-01 |
| BE865278A (fr) | 1978-09-25 |
| JPS53121791A (en) | 1978-10-24 |
| ZA781694B (en) | 1979-03-28 |
| DD143777A5 (de) | 1980-09-10 |
| NL7803431A (nl) | 1978-10-03 |
| DD137108A5 (de) | 1979-08-15 |
| FR2385721A1 (fr) | 1978-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU913283D0 (en) | Process for the production of hydroximethyl-(methylene-cyclopentyl)-purines and pirimidines, their medically usable salts, and of medical preparations containing them | |
| HUT47217A (en) | Process for producing pharmaceutical compositions containing indol derivatives as active components | |
| FR2387954A1 (fr) | Derives de mercaptoalkylsulfonylproline et composes apparentes, et leur utilisation comme medicaments | |
| GB2071088B (en) | Indane derivatives | |
| IE45256L (en) | Quinazolone derivatives | |
| PT67164A (en) | Process for the preparation of hydantoin derivatives as therapeutic agents | |
| EP0132764A3 (en) | New compounds derived from diphenyl-methylene-ethylamine | |
| EP0150505A3 (en) | 3-indolecarboxamide compounds | |
| ES475361A1 (es) | Procedimiento para preparar un nuevo derivado de piridina | |
| FR2458556B1 (es) | ||
| ES431497A1 (es) | Procedimiento para preparar un derivado de s-triazol (1,5- a) piridina. | |
| IE44339L (en) | Piperazine derivatives. | |
| ZA784471B (en) | Derivatives of 1,3-diphenoxypropane-2-on,process for their preparation,medicaments thereof,and their use as medicaments | |
| ATE40127T1 (de) | 1,5-benzothiazepinderivate, verfahren zu ihrer herstellung und arzneimittel. | |
| ES468382A1 (es) | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihidro-1-metil-5-fenil-2-oxo-2h-tieno(2,3-e)diazepina | |
| HU206669B (en) | Process for producing new salts of diphenyl-acetic acid and aryl-propanol-amines | |
| ES474367A1 (es) | Procedimiento de preparacion de nuevos derivados del benzo- (d)tiazol. | |
| IE780279L (en) | Imidazole derivatives | |
| FR2336134A1 (fr) | Derives trifluoromethylthio de cyproheptadine utiles comme medicament | |
| ES8400384A1 (es) | Procedimiento para la preparacion de derivados de carbaciclina. | |
| YU104986A (en) | Process for obtaining penem derivatives | |
| HU912216D0 (en) | Process for the production of purinyl-and pirimidinyl - tetrahydrofurane derivatives and medical preparations containing them | |
| ES8405021A1 (es) | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. | |
| NO164170C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzhydryl-4-cinnamyl-piperazinderivater. | |
| GB2011887A (en) | Antiallergic agent |