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ES476124A1 - Un procedimiento para la preparacion de derivados peptidicos. - Google Patents

Un procedimiento para la preparacion de derivados peptidicos.

Info

Publication number
ES476124A1
ES476124A1 ES476124A ES476124A ES476124A1 ES 476124 A1 ES476124 A1 ES 476124A1 ES 476124 A ES476124 A ES 476124A ES 476124 A ES476124 A ES 476124A ES 476124 A1 ES476124 A1 ES 476124A1
Authority
ES
Spain
Prior art keywords
group
lower alkyl
formula
configuration
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476124A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES476124A1 publication Critical patent/ES476124A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de derivados peptídicos de la fórmula general **fórmula** en donde R1 representa un átomo de hidrógeno o el grupo de metilo o hidroximetilo o un grupo mono- di-o trihalometilico; R2 representa un grupo de alquilo inferior , hidroxi-(alquilo inferior) o guanidino-(alquilo inferior) distinto del grupo caracterizante de un alfa aminoácido del tipo que se encuentra normalmente en las proteínas; La configuración en el átomo de carbono designada como (a) es (R) cuando R1 tiene un significado distinto a un átomo de hidrógeno y La configuración en el átomo de carbono designada como (b) es (L), Y sus sales aceptables en farmacia, caracterizado porque comprende condensar un compuesto de la fórmula general **fórmula** en donde R10 tiene cualquiera de los valores acordados para R1 anterior o representa un grupo hidroximetilico protegido; R3 Y R4 representa, cada uno, un átomo de hidrógeno o un grupo protector de alquilo inferior; y la configuración en el átomo decarbono designada como (a) es (R) cuando R10 tiene un significado distinto a un átomo de hidrógeno, con un alfa aminoácido protegido de la fórmula general ** fórmula** en donde R20 tiene cualquiera de los valores acordados para R2 anterior o representa un grupo protegido de hidroxi-(alquilo inferior) o guanidino-(alquilo inferior R5 representa un grupo amínico protegido y la configuración en el átomo de carbono designado como (b) es (L) disociando el grupo protector o grupos protectores presenta en el producto de condensación y, si se desea, convirtiendo un compuesto resultante de la fórmula I en una sal aceptable en farmacia.
ES476124A 1977-12-20 1978-12-19 Un procedimiento para la preparacion de derivados peptidicos. Expired ES476124A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5293877 1977-12-20
GB7842727 1978-11-01

Publications (1)

Publication Number Publication Date
ES476124A1 true ES476124A1 (es) 1980-07-16

Family

ID=26267167

Family Applications (1)

Application Number Title Priority Date Filing Date
ES476124A Expired ES476124A1 (es) 1977-12-20 1978-12-19 Un procedimiento para la preparacion de derivados peptidicos.

Country Status (23)

Country Link
EP (1) EP0002534B1 (es)
JP (1) JPS5492921A (es)
AT (1) AT366057B (es)
AU (1) AU4248378A (es)
BR (1) BR7808342A (es)
CS (1) CS211394B2 (es)
CU (1) CU35001A (es)
DE (2) DE2854292A1 (es)
DK (1) DK536578A (es)
ES (1) ES476124A1 (es)
FI (1) FI783886A7 (es)
FR (1) FR2450260A1 (es)
GR (1) GR73085B (es)
IL (1) IL56208A0 (es)
IT (1) IT1102401B (es)
LU (1) LU80671A1 (es)
MC (1) MC1242A1 (es)
NL (1) NL7812311A (es)
NO (1) NO784285L (es)
NZ (1) NZ189151A (es)
PT (1) PT68938A (es)
SE (1) SE7813069L (es)
ZA (1) ZA786976B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1307787C (en) * 1986-06-11 1992-09-22 Melanie J. Loots Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
CN110156640A (zh) * 2019-06-14 2019-08-23 南京博源医药科技有限公司 一种n-苄氧羰基-氨基酸的制备工艺
CN110143896A (zh) * 2019-06-14 2019-08-20 南京博源医药科技有限公司 一种n-苄氧羰基-l-己氨酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1081511B (it) * 1976-07-13 1985-05-21 Hoffmann La Roche Derivati di peptidi e loro preparazione
DE2632188A1 (de) * 1976-07-16 1978-01-26 Hoffmann La Roche Wirkstoffkombinationen
GB1585275A (en) * 1976-07-21 1981-02-25 Roche Products Ltd Peptide derivatives of phosphonic and phosphinic acids

Also Published As

Publication number Publication date
FR2450260A1 (fr) 1980-09-26
EP0002534A1 (de) 1979-06-27
IT7831023A0 (it) 1978-12-19
EP0002534B1 (de) 1982-01-13
CU35001A (en) 1981-12-04
NL7812311A (nl) 1979-06-22
JPS5492921A (en) 1979-07-23
PT68938A (en) 1979-01-01
IT1102401B (it) 1985-10-07
GR73085B (es) 1984-01-31
ATA904178A (de) 1981-07-15
LU80671A1 (de) 1980-01-22
CS211394B2 (en) 1982-02-26
NZ189151A (en) 1981-05-15
MC1242A1 (fr) 1979-10-26
DE2861537D1 (en) 1982-02-25
IL56208A0 (en) 1979-03-12
AU4248378A (en) 1979-06-28
AT366057B (de) 1982-03-10
NO784285L (no) 1979-06-21
BR7808342A (pt) 1979-08-07
DK536578A (da) 1979-06-21
DE2854292A1 (de) 1979-07-05
ZA786976B (en) 1980-07-30
SE7813069L (sv) 1979-06-21
FI783886A7 (fi) 1979-06-21

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