ES462346A1 - PROCEDURE FOR PREPARING AMIDOXIME DERIVATIVES. - Google Patents
PROCEDURE FOR PREPARING AMIDOXIME DERIVATIVES.Info
- Publication number
- ES462346A1 ES462346A1 ES77462346A ES462346A ES462346A1 ES 462346 A1 ES462346 A1 ES 462346A1 ES 77462346 A ES77462346 A ES 77462346A ES 462346 A ES462346 A ES 462346A ES 462346 A1 ES462346 A1 ES 462346A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- amidoxime derivatives
- alkyl
- carbon atoms
- preparing amidoxime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical class C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Procedimiento para preparar derivados de amidoxima, de la fórmula general I y sus sales farmacéuticamente aceptables ***(Ver fórmula I), en que, R2 es hidrógeno o alquilo que tiene de uno a cinco átomos de carbono; R3 es alquilo que tiene de uno a cinco átomos de carbono, cicloalquilo o fenilo opcionalmente substituido con hidróxilo o fenilo; o R2 y R3 forman conjuntamente un anillo de cinco a ocho miembros que contiene opcionalmente también otros heteroátomos y/o fusionado con otro anillo.Procedure for preparing amidoxime derivatives, of the general formula I and their pharmaceutically acceptable salts ***(See formula I), in which R2 is hydrogen or alkyl having from one to five carbon atoms; R3 is alkyl having from one to five carbon atoms, cycloalkyl, or phenyl optionally substituted with hydroxyl or phenyl; or R2 and R3 together form a five to eight membered ring optionally also containing other heteroatoms and/or fused to another ring.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU76CI1682A HU177578B (en) | 1976-08-27 | 1976-08-27 | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES462346A1 true ES462346A1 (en) | 1978-06-16 |
Family
ID=10994625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES77462346A Expired ES462346A1 (en) | 1976-08-27 | 1977-09-08 | PROCEDURE FOR PREPARING AMIDOXIME DERIVATIVES. |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5350131A (en) |
| AT (1) | AT355554B (en) |
| AU (1) | AU521432B2 (en) |
| BE (1) | BE858134A (en) |
| CA (1) | CA1077506A (en) |
| CH (1) | CH630344A5 (en) |
| CS (1) | CS204008B2 (en) |
| DD (1) | DD132433A5 (en) |
| DE (1) | DE2738589A1 (en) |
| DK (1) | DK150196C (en) |
| ES (1) | ES462346A1 (en) |
| FI (1) | FI68396C (en) |
| FR (1) | FR2362845A1 (en) |
| GB (1) | GB1582029A (en) |
| GR (1) | GR63623B (en) |
| HU (1) | HU177578B (en) |
| IL (1) | IL52804A (en) |
| NL (1) | NL187478C (en) |
| NO (1) | NO144793C (en) |
| PL (1) | PL107628B1 (en) |
| SE (1) | SE435280B (en) |
| SU (1) | SU730296A3 (en) |
| YU (2) | YU202377A (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA848428B (en) * | 1983-11-03 | 1985-06-26 | Merrell Pharma Inc | Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones |
| US5212314A (en) * | 1983-11-03 | 1993-05-18 | Merrell Dow Pharmaceuticals Inc. | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
| US4849522A (en) * | 1983-11-03 | 1989-07-18 | Merrell Dow Pharmaceuticals | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
| JPH01169445A (en) * | 1987-12-25 | 1989-07-04 | Fuji Photo Film Co Ltd | Focal distance switching camera |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HUT54347A (en) * | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| HU222994B1 (en) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hydroxylamine derivatives and use thereof in the preparation of a pharmaceutical compositions for enhancing of molecular chaperon production of cells |
| HUT78139A (en) * | 1995-12-22 | 2000-11-28 | BIOREX Kutató és Fejlesztő Rt. | Composition for reducing skin state aging |
| HUP9602204D0 (en) * | 1996-08-09 | 1996-10-28 | Biorex Rt | Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells |
| AU766831B2 (en) | 1998-05-11 | 2003-10-23 | Takeda Pharmaceutical Company Limited | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity |
| WO2000007580A2 (en) * | 1998-08-03 | 2000-02-17 | N-Gene Kutató Kft. | Pharmaceutical compositions against autoimmune diseases |
| MXPA04006716A (en) | 2002-01-11 | 2004-11-10 | Biorex Kutato Es Rejleszt Rt | Carboxamidine derivatives and their use in the treatment of vascular diseases. |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| KR20230128462A (en) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | Process for preparing arimoclomol citrate and intermediates thereof |
-
1976
- 1976-08-27 HU HU76CI1682A patent/HU177578B/en unknown
-
1977
- 1977-08-22 AT AT605477A patent/AT355554B/en not_active IP Right Cessation
- 1977-08-23 IL IL7752804A patent/IL52804A/en unknown
- 1977-08-23 SE SE7709482A patent/SE435280B/en not_active IP Right Cessation
- 1977-08-23 NL NLAANVRAGE7709276,A patent/NL187478C/en not_active IP Right Cessation
- 1977-08-24 CS CS775551A patent/CS204008B2/en unknown
- 1977-08-24 GR GR54222A patent/GR63623B/en unknown
- 1977-08-24 DD DD7700200719A patent/DD132433A5/en unknown
- 1977-08-25 YU YU02023/77A patent/YU202377A/en unknown
- 1977-08-25 GB GB35745/77A patent/GB1582029A/en not_active Expired
- 1977-08-26 CH CH1047377A patent/CH630344A5/en not_active IP Right Cessation
- 1977-08-26 FR FR7726070A patent/FR2362845A1/en active Granted
- 1977-08-26 DK DK379777A patent/DK150196C/en not_active IP Right Cessation
- 1977-08-26 FI FI772551A patent/FI68396C/en not_active IP Right Cessation
- 1977-08-26 JP JP10250477A patent/JPS5350131A/en active Granted
- 1977-08-26 AU AU28254/77A patent/AU521432B2/en not_active Expired
- 1977-08-26 PL PL1977206476A patent/PL107628B1/en unknown
- 1977-08-26 DE DE19772738589 patent/DE2738589A1/en active Granted
- 1977-08-26 SU SU772514754A patent/SU730296A3/en active
- 1977-08-26 BE BE180447A patent/BE858134A/en not_active IP Right Cessation
- 1977-08-26 CA CA285,529A patent/CA1077506A/en not_active Expired
- 1977-08-26 NO NO772958A patent/NO144793C/en unknown
- 1977-09-08 ES ES77462346A patent/ES462346A1/en not_active Expired
-
1982
- 1982-10-22 YU YU02377/82A patent/YU237782A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5350131A (en) | 1978-05-08 |
| ATA605477A (en) | 1979-08-15 |
| NL7709276A (en) | 1978-03-01 |
| DD132433A5 (en) | 1978-09-27 |
| BE858134A (en) | 1977-12-16 |
| CS204008B2 (en) | 1981-03-31 |
| FI68396B (en) | 1985-05-31 |
| NL187478C (en) | 1991-10-16 |
| FR2362845A1 (en) | 1978-03-24 |
| DK150196C (en) | 1987-07-06 |
| HU177578B (en) | 1981-11-28 |
| DE2738589A1 (en) | 1978-03-02 |
| AT355554B (en) | 1980-03-10 |
| FI68396C (en) | 1985-09-10 |
| JPS6216942B2 (en) | 1987-04-15 |
| PL107628B1 (en) | 1980-02-29 |
| GR63623B (en) | 1979-11-27 |
| SE7709482L (en) | 1978-02-28 |
| IL52804A0 (en) | 1977-10-31 |
| CH630344A5 (en) | 1982-06-15 |
| DK150196B (en) | 1987-01-05 |
| AU521432B2 (en) | 1982-04-01 |
| FR2362845B1 (en) | 1981-01-09 |
| YU202377A (en) | 1983-12-31 |
| SU730296A3 (en) | 1980-04-25 |
| NO144793C (en) | 1981-11-11 |
| DK379777A (en) | 1978-02-28 |
| NO144793B (en) | 1981-08-03 |
| CA1077506A (en) | 1980-05-13 |
| IL52804A (en) | 1981-06-29 |
| YU237782A (en) | 1983-12-31 |
| NO772958L (en) | 1978-02-28 |
| GB1582029A (en) | 1980-12-31 |
| SE435280B (en) | 1984-09-17 |
| AU2825477A (en) | 1979-03-01 |
| FI772551A7 (en) | 1978-02-28 |
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