MX2978E - PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINE - Google Patents
PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINEInfo
- Publication number
- MX2978E MX2978E MX003804U MX380473U MX2978E MX 2978 E MX2978 E MX 2978E MX 003804 U MX003804 U MX 003804U MX 380473 U MX380473 U MX 380473U MX 2978 E MX2978 E MX 2978E
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- piperazine
- preparation
- pyrimidine
- see
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- IBMKUYMVNFUNOW-UHFFFAOYSA-N 5-methylsulfanylpyrimidine Chemical compound CSC1=CN=CN=C1 IBMKUYMVNFUNOW-UHFFFAOYSA-N 0.000 abstract 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 methyl methylthio group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de derivados sustituídos de piperazina 5-metil ó 5-metiltio-pirimidina, de la fórmula general: (VER FIGURA), en la que R representa un grupo metilo metiltio, X representa un átomo de halógeno o un grupo alcoxi que tiene de 1 a 5 átomos de carbono, Y representa un grupo acilamino, o amino aventualmente sustituído, Z representa un átomo de hidrógeno, un grupo metilo, etilo, hidroxietilo o fenilo, con la excepción de la metilamina-2-N-metilpiperazina-4 metilotio-5 cloro-5 pirimidina, caracterizado en que se hace reaccionar un dicloro-4,6 pirimidina de fórmula: (VER FIGURA), con una piperazina de fórmula: (VER FIGURA), un medio anhidro, en presencia de un agente que absorbe los ácidos a una temperatura comprendida entre 40 y 120°C.The present invention relates to a process for the preparation of substituted piperazine derivatives 5-methyl or 5-methylthio-pyrimidine, of the general formula: (SEE FIGURE), in which R represents a methyl methylthio group, X represents an atom of halogen or an alkoxy group having 1 to 5 carbon atoms, Y represents an acylamino, or aventually substituted amino group, Z represents a hydrogen atom, a methyl, ethyl, hydroxyethyl or phenyl group, with the exception of methylamine -2-N-methylpiperazine-4-methylothio-5-chloro-5-pyrimidine, characterized in that a dichloro-4,6-pyrimidine of the formula: (SEE FIGURE) is reacted with a piperazine of the formula: (SEE FIGURE), a medium anhydrous, in the presence of an acid-absorbing agent at a temperature between 40 and 120 ° C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7324874A FR2257294B1 (en) | 1973-07-06 | 1973-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2978E true MX2978E (en) | 1980-01-17 |
Family
ID=9122191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX003804U MX2978E (en) | 1973-07-06 | 1973-11-08 | PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINE |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5849548B2 (en) |
| BE (1) | BE803803A (en) |
| CH (1) | CH582171A5 (en) |
| DE (1) | DE2342880A1 (en) |
| ES (1) | ES418113A1 (en) |
| FR (1) | FR2257294B1 (en) |
| GB (1) | GB1434544A (en) |
| LU (1) | LU68263A1 (en) |
| MX (1) | MX2978E (en) |
| NO (1) | NO137205C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH602663A5 (en) * | 1975-05-23 | 1978-07-31 | Mar Pha Etu Expl Marques | |
| FR2417507A2 (en) * | 1977-07-28 | 1979-09-14 | Ugine Kuhlmann | DIAMINO-2,4 (OR -4,6) METHYLTHIO-5 PYRIMIDINES HERBICIDES |
| JPS54159877A (en) * | 1978-06-07 | 1979-12-18 | Matsushita Electronics Corp | Detection method for semiconductor substrate position and break |
| FR2503162A1 (en) * | 1981-04-07 | 1982-10-08 | Pharmindustrie | NOVEL PIPERAZINO-2 PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS OR AS INTERMEDIATES FOR THE PRODUCTION OF MEDICAMENTS |
| JPS6177335A (en) * | 1984-09-25 | 1986-04-19 | Kazumichi Kimura | Defective mark detector for semiconductor pellet |
| IT1191845B (en) * | 1986-01-20 | 1988-03-23 | Dompe Farmaceutici Spa | PHARMACOLOGICALLY ACTIVE ALCHYLOLS |
| JPH02114936U (en) * | 1989-03-03 | 1990-09-14 |
-
1973
- 1973-07-06 FR FR7324874A patent/FR2257294B1/fr not_active Expired
- 1973-08-16 NO NO3260/73A patent/NO137205C/en unknown
- 1973-08-20 LU LU68263A patent/LU68263A1/xx unknown
- 1973-08-20 BE BE134751A patent/BE803803A/en not_active IP Right Cessation
- 1973-08-22 ES ES418113A patent/ES418113A1/en not_active Expired
- 1973-08-23 CH CH1213673A patent/CH582171A5/xx not_active IP Right Cessation
- 1973-08-24 DE DE19732342880 patent/DE2342880A1/en not_active Ceased
- 1973-09-06 JP JP48100728A patent/JPS5849548B2/en not_active Expired
- 1973-09-12 GB GB4286673A patent/GB1434544A/en not_active Expired
- 1973-11-08 MX MX003804U patent/MX2978E/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2342880A1 (en) | 1975-01-30 |
| GB1434544A (en) | 1976-05-05 |
| NO326073L (en) | 1975-02-03 |
| NO137205C (en) | 1978-01-18 |
| FR2257294A1 (en) | 1975-08-08 |
| FR2257294B1 (en) | 1977-07-01 |
| CH582171A5 (en) | 1976-11-30 |
| ES418113A1 (en) | 1976-03-16 |
| NO137205B (en) | 1977-10-10 |
| JPS5025578A (en) | 1975-03-18 |
| LU68263A1 (en) | 1973-10-24 |
| JPS5849548B2 (en) | 1983-11-05 |
| BE803803A (en) | 1974-02-20 |
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