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ES469182A1 - Un procedimiento para la preparacion de nuevos derivados de acido clavulanico - Google Patents

Un procedimiento para la preparacion de nuevos derivados de acido clavulanico

Info

Publication number
ES469182A1
ES469182A1 ES469182A ES469182A ES469182A1 ES 469182 A1 ES469182 A1 ES 469182A1 ES 469182 A ES469182 A ES 469182A ES 469182 A ES469182 A ES 469182A ES 469182 A1 ES469182 A1 ES 469182A1
Authority
ES
Spain
Prior art keywords
lower alkyl
aryl
cor8
cor4
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469182A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB17660/77A external-priority patent/GB1603208A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES469182A1 publication Critical patent/ES469182A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados del ácido clavulánico de fórmula (II): **(Fórmula)** donde A es un grupo tal que CO2A es un grupo ácido carboxílico o una sal o éster del mismo; R1 es un átomo de hidrógeno o un grupo CO2R3, COR4 u OR5, donde R3 es un grupo alquilo inferior, alquenilo inferior, alquil (inferior) arilo o arilo, R4 es un grupo alquilo inferior, alquenilo inferior, alquil (inferior) arilo o arilo y R5 es un grupo CO2R6, COR6 o SO2R6, donde R6 es un grupo alquilo inferior, alquenilo inferior, alquil (inferior) arilo o arilo; y R2 es un átomo de hidrógeno o un grupo CO2R7 o COR8, donde R7 es un grupo alquilo inferior, alquenilo inferior, alquil (inferior) arilo o arilo y R8 es un grupo alquilo inferior, alquenilo inferior, alquil (inferior) arilo o arilo.
ES469182A 1977-04-27 1978-04-26 Un procedimiento para la preparacion de nuevos derivados de acido clavulanico Expired ES469182A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB17660/77A GB1603208A (en) 1977-04-27 1977-04-27 Aminodeoxyclavulanic acid and acyl derivatives threreof
GB3283577 1977-08-05
GB4739477 1977-11-15

Publications (1)

Publication Number Publication Date
ES469182A1 true ES469182A1 (es) 1979-09-16

Family

ID=27257529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES469182A Expired ES469182A1 (es) 1977-04-27 1978-04-26 Un procedimiento para la preparacion de nuevos derivados de acido clavulanico

Country Status (16)

Country Link
US (1) US4258050A (es)
JP (1) JPS53135999A (es)
AT (1) AT358170B (es)
AU (1) AU524985B2 (es)
DE (1) DE2818309A1 (es)
DK (1) DK181778A (es)
ES (1) ES469182A1 (es)
FI (1) FI781217A7 (es)
FR (1) FR2431497A1 (es)
GR (1) GR64678B (es)
LU (1) LU79540A1 (es)
NO (1) NO781460L (es)
NZ (1) NZ187013A (es)
PH (1) PH14049A (es)
PT (1) PT67951B (es)
SE (1) SE7804735L (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604822A (en) 1977-04-22 1981-12-16 Beecham Group Ltd N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative
EP0005014A1 (en) * 1978-04-22 1979-10-31 Beecham Group Plc Clavulanic acid derivatives, preparation and compositions
DE3165543D1 (en) * 1980-06-11 1984-09-20 Beecham Group Plc Process for the preparation of beta-lactam antibiotics
EP0068617A1 (en) * 1981-06-12 1983-01-05 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their use
GB9503717D0 (en) * 1995-02-24 1995-04-12 Smithkline Beecham Plc Novel compounds
JP2001516365A (ja) * 1997-11-17 2001-09-25 ギスト ブロカデス ベスローテン フェンノートシャップ クラブラネート及び１種以上の賦形剤を含む顆粒

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1547169A (en) * 1975-10-13 1979-06-06 Beecham Group Ltd Clavulanic acid derivatives
US4078067A (en) * 1976-04-12 1978-03-07 Merck & Co., Inc. 3-(.beta.-Aminoethylidene)-7-oxo-4-oxaazabicyclo[3.2.0]heptane-2-carboxylic acid and derivatives thereof

Also Published As

Publication number Publication date
US4258050A (en) 1981-03-24
PH14049A (en) 1980-12-29
NZ187013A (en) 1985-04-30
JPS53135999A (en) 1978-11-28
PT67951B (en) 1979-11-14
DK181778A (da) 1978-10-28
GR64678B (en) 1980-05-13
SE7804735L (sv) 1978-10-28
ATA304478A (de) 1980-01-15
AU3553078A (en) 1979-11-01
FI781217A7 (fi) 1978-10-28
DE2818309A1 (de) 1978-11-02
AT358170B (de) 1980-08-25
FR2431497B1 (es) 1983-08-12
NO781460L (no) 1978-10-30
FR2431497A1 (fr) 1980-02-15
LU79540A1 (fr) 1978-09-29
AU524985B2 (en) 1982-10-14
PT67951A (en) 1978-05-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301