ES468749A1 - Un procedimiento para preparar una composicion antibiotica - Google Patents
Un procedimiento para preparar una composicion antibioticaInfo
- Publication number
- ES468749A1 ES468749A1 ES468749A ES468749A ES468749A1 ES 468749 A1 ES468749 A1 ES 468749A1 ES 468749 A ES468749 A ES 468749A ES 468749 A ES468749 A ES 468749A ES 468749 A1 ES468749 A1 ES 468749A1
- Authority
- ES
- Spain
- Prior art keywords
- antibiotic
- solution
- alkaline earth
- compound
- tetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229940072172 tetracycline antibiotic Drugs 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000004099 Chlortetracycline Substances 0.000 abstract 2
- 239000004100 Oxytetracycline Substances 0.000 abstract 2
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 abstract 2
- 229960004475 chlortetracycline Drugs 0.000 abstract 2
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 abstract 2
- 235000019365 chlortetracycline Nutrition 0.000 abstract 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 abstract 2
- 229960000625 oxytetracycline Drugs 0.000 abstract 2
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 2
- 235000019366 oxytetracycline Nutrition 0.000 abstract 2
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 abstract 2
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 1
- SVDOODSCHVSYEK-IFLJXUKPSA-N (4s,4ar,5s,5ar,6s,12ar)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydron;chloride Chemical compound Cl.C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O SVDOODSCHVSYEK-IFLJXUKPSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 229940043430 calcium compound Drugs 0.000 abstract 1
- 150000001674 calcium compounds Chemical class 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 229960003722 doxycycline Drugs 0.000 abstract 1
- 150000002681 magnesium compounds Chemical class 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Un procedimiento para preparar una composición antibiótica estable que contiene una alta concentración del antibiótico en solución; caracterizado por hacer reaccionar un antibiótico de tetraciclina con una suspensión espesa que consiste de un compuesto alcalinotérreo farmacéuticamente aceptable y, si se desea, pirrolidona de polivinilo, en caprolactama o 2-piperidona acuosa para formar un quelato de metal alcalinotérreo/tetraciclina y ajustar el valor del pH, si es necesario para lograr una solución, el antibiótico se selecciona de oxitetraciclina, oxiciclina, clortetraciclina y las sales de adición de ácido farmacéuticamente aceptables de los mismos, con la condición de que cuando el antibiótico es clortetraciclina, el compuesto alcalinotérreo sea un compuesto de calcio soluble en la solución y cuando el antibiótico es oxitetraciclina o doxiciclina, el compuesto alcalinotérreo sea un compuesto de magnesio, soluble en esa solución.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/791,627 US4126680A (en) | 1977-04-27 | 1977-04-27 | Tetracycline antibiotic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES468749A1 true ES468749A1 (es) | 1979-01-01 |
Family
ID=25154289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468749A Expired ES468749A1 (es) | 1977-04-27 | 1978-04-13 | Un procedimiento para preparar una composicion antibiotica |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US4126680A (es) |
| JP (1) | JPS53136514A (es) |
| AR (1) | AR217844A1 (es) |
| AT (1) | AT360148B (es) |
| AU (1) | AU503139B1 (es) |
| BE (1) | BE866419A (es) |
| BG (1) | BG47943A3 (es) |
| CA (1) | CA1100875A (es) |
| CH (1) | CH630260A5 (es) |
| CS (1) | CS199527B2 (es) |
| DD (1) | DD135445A5 (es) |
| DE (1) | DE2817335C3 (es) |
| DK (1) | DK155977C (es) |
| EG (1) | EG14348A (es) |
| ES (1) | ES468749A1 (es) |
| FI (3) | FI801197A7 (es) |
| FR (1) | FR2388561A1 (es) |
| GB (1) | GB1563478A (es) |
| GR (1) | GR70062B (es) |
| HU (1) | HU179050B (es) |
| IE (1) | IE47049B1 (es) |
| IL (1) | IL54581A0 (es) |
| IN (1) | IN148197B (es) |
| IT (1) | IT1094557B (es) |
| LU (1) | LU79547A1 (es) |
| MX (1) | MX6087E (es) |
| NL (1) | NL7804455A (es) |
| NO (1) | NO148280C (es) |
| NZ (1) | NZ187046A (es) |
| OA (1) | OA05949A (es) |
| PH (1) | PH12962A (es) |
| PL (1) | PL110459B1 (es) |
| PT (1) | PT67895B (es) |
| RO (2) | RO75099A (es) |
| SE (1) | SE443507B (es) |
| YU (1) | YU87178A (es) |
| ZA (1) | ZA782400B (es) |
| ZM (1) | ZM3878A1 (es) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4386083A (en) * | 1980-04-10 | 1983-05-31 | Walter Hacke | Injectable oxytetracycline compositions |
| US4399127A (en) * | 1980-04-10 | 1983-08-16 | Diamond Shamrock Corporation | Injectable oxytetracycline compositions |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US4769232A (en) * | 1984-03-22 | 1988-09-06 | Pfizer Inc. | Parenteral formulations of indolmycin |
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| EP0621033A1 (en) * | 1993-04-20 | 1994-10-26 | Nostras S.A. | Antibiotic composition containing oxytetracycline and glycofurol |
| US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| EA016099B1 (ru) | 1999-09-14 | 2012-02-28 | Трастис Оф Тафтс Коллидж | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| CA2397863A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| CN1430600A (zh) | 2000-03-31 | 2003-07-16 | 塔夫茨大学信托人 | 7－和9－氨基甲酸酯、脲、硫脲、硫代氨基甲酸酯,和杂芳基－氨基取代的四环素化合物 |
| JP2003533504A (ja) | 2000-05-15 | 2003-11-11 | パラテック ファーマシューティカルズ インコーポレイテッド | ７置換型縮合環テトラサイクリン化合物 |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| WO2001098236A2 (en) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| BRPI0112269B8 (pt) | 2000-07-07 | 2021-05-25 | Paratek Pharm Innc | composto de minociclina 9-aminometila substituída, e, composição farmacêutica |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| JP4963771B2 (ja) | 2000-07-07 | 2012-06-27 | トラスティーズ・オブ・タフツ・カレッジ | ７、８および９−置換テトラサイクリン化合物 |
| US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
| EP2289871A1 (en) | 2000-07-07 | 2011-03-02 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
| IL153674A0 (en) | 2000-07-07 | 2003-07-06 | Tufts College | 13-substituted methacycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EP2301914A1 (en) | 2001-03-13 | 2011-03-30 | Paratek Pharmaceuticals, Inc. | 7,9-Substituted tetracycline compounds |
| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| CA2440757A1 (en) | 2001-03-14 | 2002-09-19 | Michael Draper | Substituted tetracycline compounds as synergistic antifungal agents |
| EP1379255A2 (en) | 2001-03-14 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| WO2002085303A2 (en) | 2001-04-24 | 2002-10-31 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP1474380A4 (en) * | 2002-01-08 | 2007-04-18 | Paratek Pharm Innc | 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS |
| CN101307017A (zh) | 2002-03-08 | 2008-11-19 | 帕拉特克药品公司 | 氨基-甲基取代的四环素类化合物 |
| CA2479877C (en) | 2002-03-21 | 2012-08-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1534300A4 (en) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
| JP2006503898A (ja) | 2002-10-24 | 2006-02-02 | パラテック ファーマシューティカルズ， インク． | マラリア治療のための置換テトラサイクリン化合物 |
| AU2004259659B2 (en) | 2003-07-09 | 2011-11-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2004259661B2 (en) | 2003-07-09 | 2011-11-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US7485319B2 (en) * | 2003-07-25 | 2009-02-03 | Warner Chilcott Company, Inc. | Doxycycline metal complex in a solid dosage form |
| US7786099B2 (en) * | 2004-01-15 | 2010-08-31 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| EP2949644A3 (en) | 2004-10-25 | 2016-04-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US7858601B2 (en) * | 2004-10-25 | 2010-12-28 | Paratek Pharmaceuticals, Inc. | 4-substituted tetracyclines and methods of use thereof |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US7541347B2 (en) * | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
| US20080242642A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
| US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7544373B2 (en) * | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| WO2007087416A2 (en) * | 2006-01-24 | 2007-08-02 | Paratek Pharaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| EP2007713A2 (en) * | 2006-04-17 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Isolation of tetracycline derivatives |
| CN101479235B (zh) * | 2006-04-24 | 2013-09-18 | 特瓦制药工业有限公司 | 替加环素晶形及其制备方法 |
| US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
| EP2026776A2 (en) * | 2006-05-15 | 2009-02-25 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| ES2315123B1 (es) * | 2006-09-25 | 2009-12-30 | Divasa-Farmavic, S.A. | Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos. |
| US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| EP2450347B1 (en) | 2006-12-21 | 2015-06-24 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| AU2007338681B2 (en) | 2006-12-21 | 2013-09-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| JP5395052B2 (ja) * | 2007-03-23 | 2014-01-22 | モレキュラー リサーチ センター インコーポレイテッド | 炎症を処置するための組成物および方法 |
| AU2012230089B2 (en) * | 2007-03-23 | 2013-11-21 | Molecular Research Center, Inc. | Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy |
| US20080241197A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline dosage forms for the treatment of acne |
| CA2688725A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| CA2688662A1 (en) | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2192111A3 (en) | 2007-07-06 | 2010-10-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing substituted tetracycline compounds |
| RU2010140682A (ru) | 2008-03-05 | 2012-04-10 | Пэрэтек Фамэсьютикэлс, Инк. (US) | Способ лечения пациента от инфекции, фармацевтическая композиция (варианты) и лекарственное средство |
| PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| TW202332671A (zh) | 2008-05-19 | 2023-08-16 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| EP2341771A4 (en) * | 2008-09-19 | 2012-08-15 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED THERAPEUTIC METHODS |
| JP2012523438A (ja) | 2009-04-10 | 2012-10-04 | タフツ メディカル センター インコーポレイテッド | メタロプロテイナーゼ−１（ｍｍｐ−１）によるｐａｒ−１活性化 |
| US9255068B2 (en) | 2011-05-12 | 2016-02-09 | Warner Chilcott Company, Llc | Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| ES2611185T3 (es) * | 2013-05-20 | 2017-05-05 | Fundación Comunidad Valenciana Centro De Investigación Principe Felipe | Conjugados polímero-fármaco para el tratamiento de la amiloidosis |
| TW201705962A (zh) | 2015-03-23 | 2017-02-16 | 生物製藥Ｘ公司 | 皮膚用四環素醫藥組成物 |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| ES2962380T3 (es) | 2017-07-21 | 2024-03-18 | Almirall Llc | Sareciclina para el tratamiento de lesiones de acné no inflamatorias |
| CN113655052B (zh) * | 2021-08-03 | 2023-12-12 | 哈尔滨工程大学 | 基于高活性MgO对四环素类抗生素可视化检测的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1913323A (en) * | 1931-02-28 | 1933-06-06 | Hoffmann La Roche | Stable concentrated solution for therapeutic purposes |
| DE647766C (de) * | 1931-03-01 | 1937-07-12 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide |
| GB381012A (en) * | 1931-12-04 | 1932-09-29 | Andrew Home Morton | Process for the manufacture of stable concentrated solutions for therapeutic use |
| DE662812C (de) * | 1931-12-08 | 1938-07-22 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen |
| DE673500C (de) * | 1933-01-15 | 1939-03-23 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel |
| GB1019164A (en) * | 1963-01-30 | 1966-02-02 | Chugai Pharmaceutical Co Ltd | Hemostatic preparation for injection and process for the production thereof |
| DK129969B (da) * | 1973-01-11 | 1974-12-09 | Rosco Ak | Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin. |
| GB1508601A (en) * | 1974-01-19 | 1978-04-26 | Norbrook Labor Ltd | Oxytetracycline solution |
| US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
-
1977
- 1977-04-27 US US05/791,627 patent/US4126680A/en not_active Expired - Lifetime
-
1978
- 1978-02-16 SE SE7801816A patent/SE443507B/sv not_active IP Right Cessation
- 1978-03-30 IN IN234/DEL/78A patent/IN148197B/en unknown
- 1978-04-03 PH PH20970A patent/PH12962A/en unknown
- 1978-04-07 DD DD78204656A patent/DD135445A5/xx unknown
- 1978-04-07 MX MX787004U patent/MX6087E/es unknown
- 1978-04-08 RO RO7893756A patent/RO75099A/ro unknown
- 1978-04-08 RO RO78102215A patent/RO77953A/ro unknown
- 1978-04-11 ZM ZM38/78A patent/ZM3878A1/xx unknown
- 1978-04-12 YU YU00871/78A patent/YU87178A/xx unknown
- 1978-04-12 PT PT67895A patent/PT67895B/pt unknown
- 1978-04-13 HU HU78PI616A patent/HU179050B/hu not_active IP Right Cessation
- 1978-04-13 PL PL1978206050A patent/PL110459B1/pl unknown
- 1978-04-13 ES ES468749A patent/ES468749A1/es not_active Expired
- 1978-04-14 CS CS782444A patent/CS199527B2/cs unknown
- 1978-04-14 AR AR271783A patent/AR217844A1/es active
- 1978-04-14 BG BG039431A patent/BG47943A3/xx unknown
- 1978-04-15 EG EG256/78A patent/EG14348A/xx active
- 1978-04-20 DE DE2817335A patent/DE2817335C3/de not_active Expired
- 1978-04-21 NZ NZ187046A patent/NZ187046A/xx unknown
- 1978-04-24 JP JP4865978A patent/JPS53136514A/ja active Granted
- 1978-04-24 AU AU35378/78A patent/AU503139B1/en not_active Expired
- 1978-04-25 CA CA301,904A patent/CA1100875A/en not_active Expired
- 1978-04-25 GB GB16167/78A patent/GB1563478A/en not_active Expired
- 1978-04-26 CH CH453678A patent/CH630260A5/fr not_active IP Right Cessation
- 1978-04-26 NO NO781457A patent/NO148280C/no unknown
- 1978-04-26 FR FR7812299A patent/FR2388561A1/fr active Granted
- 1978-04-26 NL NL7804455A patent/NL7804455A/xx not_active Application Discontinuation
- 1978-04-26 FI FI801197A patent/FI801197A7/fi not_active Application Discontinuation
- 1978-04-26 GR GR56113A patent/GR70062B/el unknown
- 1978-04-26 DK DK182578A patent/DK155977C/da active
- 1978-04-26 BE BE187143A patent/BE866419A/xx not_active IP Right Cessation
- 1978-04-26 IT IT22720/78A patent/IT1094557B/it active
- 1978-04-26 AT AT300478A patent/AT360148B/de not_active IP Right Cessation
- 1978-04-26 ZA ZA00782400A patent/ZA782400B/xx unknown
- 1978-04-26 FI FI781300A patent/FI781300A7/fi not_active Application Discontinuation
- 1978-04-26 FI FI801196A patent/FI801196A7/fi not_active Application Discontinuation
- 1978-04-26 IL IL54581A patent/IL54581A0/xx not_active IP Right Cessation
- 1978-04-26 IE IE828/78A patent/IE47049B1/en not_active IP Right Cessation
- 1978-04-26 OA OA56480A patent/OA05949A/xx unknown
- 1978-04-27 LU LU79547A patent/LU79547A1/xx unknown
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