ES468133A1 - N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureas - Google Patents
N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureasInfo
- Publication number
- ES468133A1 ES468133A1 ES468133A ES468133A ES468133A1 ES 468133 A1 ES468133 A1 ES 468133A1 ES 468133 A ES468133 A ES 468133A ES 468133 A ES468133 A ES 468133A ES 468133 A1 ES468133 A1 ES 468133A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- carbon atoms
- alkyl
- ergolen
- ureas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000013877 carbamide Nutrition 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. Procedimiento para preparar derivados del cornezuelo del centeno, de fórmula I, **(fórmula 01)** en donde cada una de R1 y R2 es hidrógeno o alquilo de 1 a 4 átomos de carbono, o R1 y R2, juntas, forman una cadena alquilidénica de 2 a 5 átomos de carbono, R3 es alquilo de 1 a 4 átomos de carbono, y R4 es hidrógeno, alquilo de 1 a 4 átomos de carbono, alquilo de 1 a 4 átomos de carbono substituído por 1 a 3 átomos de halógeno, con la condición de que el átomo de carbono alfa no lleve un halógeno, o alcoximetilo de 2 a 5 átomos de carbono, y sus sales de adición de ácido, caracterizado porque se reduce selectivamente en la posición 2, 3 un compuesto de fórmula II, **(fórmula 02)** en donde R1 a R4 tienen los significados previamente indicados, en presencia de un disolvente, a temperaturas entre 0 y + 40ºC aproximadamente, y, si se desea, se convierten los compuestos de fórmula I resultantes en sus sales de adición de ácido.1. Procedure for preparing ergot derivatives of formula I, **(formula 01)** wherein each of R1 and R2 is hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 together, form an alkylidene chain of 2 to 5 carbon atoms, R3 is alkyl of 1 to 4 carbon atoms, and R4 is hydrogen, alkyl of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms substituted by 1 to 3 halogen atoms, provided that the alpha carbon atom does not carry a halogen, or C2-C5-alkoxymethyl, and their acid addition salts, characterized in that a compound is selectively reduced in the 2,3-position of formula II, **(formula 02)** in which R1 to R4 have the previously indicated meanings, in the presence of a solvent, at temperatures between approximately 0 and +40°C, and, if desired, the compounds of formula II are converted I resulting in their acid addition salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH381477A CH628049A5 (en) | 1977-03-25 | 1977-03-25 | Process for the preparation of ergolene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES468133A1 true ES468133A1 (en) | 1980-06-16 |
Family
ID=4264035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468133A Expired ES468133A1 (en) | 1977-03-25 | 1978-03-22 | N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureas |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS53119898A (en) |
| AT (1) | AT366685B (en) |
| AU (1) | AU520738B2 (en) |
| BE (1) | BE865267A (en) |
| CA (1) | CA1105009A (en) |
| CH (1) | CH628049A5 (en) |
| DE (1) | DE2810774A1 (en) |
| DK (1) | DK147072C (en) |
| ES (1) | ES468133A1 (en) |
| FI (1) | FI66375C (en) |
| GB (1) | GB1596210A (en) |
| IE (1) | IE46688B1 (en) |
| IL (1) | IL54342A (en) |
| IT (1) | IT1104183B (en) |
| NL (1) | NL7803031A (en) |
| NZ (1) | NZ186775A (en) |
| PT (1) | PT67816A (en) |
| SE (1) | SE7803040L (en) |
| SU (1) | SU1053755A3 (en) |
| ZA (1) | ZA781714B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3205169A1 (en) * | 1981-02-24 | 1982-10-14 | Sandoz-Patent-GmbH, 7850 Lörrach | NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS |
| DE3411981A1 (en) * | 1984-03-28 | 1985-10-10 | Schering AG, Berlin und Bergkamen, 1000 Berlin | METHOD FOR PRODUCING 2.3-DIHYDROERGOLINES |
| GB2173189B (en) * | 1985-02-21 | 1988-04-27 | Maruko Pharmaceutical Co | Ergoline derivatives and salts thereof and pharmaceutical compositions thereof |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
-
1977
- 1977-03-25 CH CH381477A patent/CH628049A5/en not_active IP Right Cessation
-
1978
- 1978-03-13 DE DE19782810774 patent/DE2810774A1/en not_active Withdrawn
- 1978-03-16 SE SE7803040A patent/SE7803040L/en unknown
- 1978-03-16 DK DK119778A patent/DK147072C/en not_active IP Right Cessation
- 1978-03-16 FI FI780835A patent/FI66375C/en not_active IP Right Cessation
- 1978-03-21 NL NL7803031A patent/NL7803031A/en not_active Application Discontinuation
- 1978-03-21 GB GB11112/78A patent/GB1596210A/en not_active Expired
- 1978-03-22 ES ES468133A patent/ES468133A1/en not_active Expired
- 1978-03-23 IL IL54342A patent/IL54342A/en unknown
- 1978-03-23 PT PT67816A patent/PT67816A/en unknown
- 1978-03-23 NZ NZ186775A patent/NZ186775A/en unknown
- 1978-03-23 IT IT48557/78A patent/IT1104183B/en active
- 1978-03-23 BE BE186239A patent/BE865267A/en not_active IP Right Cessation
- 1978-03-23 AT AT0207078A patent/AT366685B/en not_active IP Right Cessation
- 1978-03-23 CA CA299,678A patent/CA1105009A/en not_active Expired
- 1978-03-23 ZA ZA00781714A patent/ZA781714B/en unknown
- 1978-03-23 IE IE580/78A patent/IE46688B1/en unknown
- 1978-03-23 AU AU34483/78A patent/AU520738B2/en not_active Expired
- 1978-03-24 JP JP3316578A patent/JPS53119898A/en active Pending
- 1978-03-24 SU SU782595601A patent/SU1053755A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DE2810774A1 (en) | 1978-10-05 |
| AT366685B (en) | 1982-04-26 |
| DK147072B (en) | 1984-04-02 |
| CA1105009A (en) | 1981-07-14 |
| ZA781714B (en) | 1979-11-28 |
| DK147072C (en) | 1984-09-10 |
| IL54342A (en) | 1981-02-27 |
| GB1596210A (en) | 1981-08-19 |
| AU3448378A (en) | 1979-09-27 |
| IL54342A0 (en) | 1978-06-15 |
| BE865267A (en) | 1978-09-25 |
| IE780580L (en) | 1978-09-25 |
| NL7803031A (en) | 1978-09-27 |
| CH628049A5 (en) | 1982-02-15 |
| AU520738B2 (en) | 1982-02-25 |
| FI66375B (en) | 1984-06-29 |
| JPS53119898A (en) | 1978-10-19 |
| IT7848557A0 (en) | 1978-03-23 |
| DK119778A (en) | 1978-09-26 |
| SU1053755A3 (en) | 1983-11-07 |
| SE7803040L (en) | 1978-09-26 |
| ATA207078A (en) | 1981-09-15 |
| NZ186775A (en) | 1980-12-19 |
| IT1104183B (en) | 1985-10-21 |
| FI780835A7 (en) | 1978-09-26 |
| PT67816A (en) | 1978-04-01 |
| FI66375C (en) | 1984-10-10 |
| IE46688B1 (en) | 1983-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990503 |