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ES456287A1 - Procedimiento para la preparacion de derivados de ladano po-lioxigenados. - Google Patents

Procedimiento para la preparacion de derivados de ladano po-lioxigenados.

Info

Publication number
ES456287A1
ES456287A1 ES456287A ES456287A ES456287A1 ES 456287 A1 ES456287 A1 ES 456287A1 ES 456287 A ES456287 A ES 456287A ES 456287 A ES456287 A ES 456287A ES 456287 A1 ES456287 A1 ES 456287A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
derivatives
formula
polyoxygenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES456287A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES456287A1 publication Critical patent/ES456287A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyethers (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de ládano polioxigenados de la formula I (**formula**) en la que R1, R2, R3 y R4, que pueden ser iguales o diferentes, representan oxígeno o H OR6, significando R6 hidrogeno o un grupo alcohilo, alquenilo o alquinilo de 1 a 6 átomos de carbono, o un grupo cilcoalcohilo de 5 a 8 átomos de carbono, o un grupo cicloalcohilo de 5 a 8 átomos de carbono, o un grupo dialcohilaminoalcohilo o un grupo aralcohilo, en los que los grupos alcohilo tienen como máximo 4 átomos de carbono, o un grupo acilo de 1 a 20 átomos de carbono o un grupo alcoxicarbonilo o arilaminocarbonilo de 2 a 10 átomos de carbono, y R5 representa un grupo etilo o un grupo vinilo, así como de sus estereoisómeros y, en el caso de que los derivados contengan grupos básicos, sus sales por adición de ácido.
ES456287A 1976-12-03 1977-02-25 Procedimiento para la preparacion de derivados de ladano po-lioxigenados. Expired ES456287A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762654796 DE2654796A1 (de) 1976-12-03 1976-12-03 Polyoxygenierte labdan-derivate

Publications (1)

Publication Number Publication Date
ES456287A1 true ES456287A1 (es) 1978-06-01

Family

ID=5994581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES456287A Expired ES456287A1 (es) 1976-12-03 1977-02-25 Procedimiento para la preparacion de derivados de ladano po-lioxigenados.

Country Status (13)

Country Link
US (1) US4134986A (es)
JP (1) JPS5371077A (es)
BE (1) BE852060A (es)
DE (1) DE2654796A1 (es)
DK (1) DK55377A (es)
ES (1) ES456287A1 (es)
FI (1) FI770401A7 (es)
FR (1) FR2372822A1 (es)
IT (1) IT1075566B (es)
NL (1) NL7702129A (es)
NO (1) NO770401L (es)
SE (1) SE7701310L (es)
ZA (1) ZA771052B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782082A (en) * 1982-12-27 1988-11-01 Schering Corporation Method for treating allergic reactions with Forskolin
US4517200A (en) * 1982-12-27 1985-05-14 Schering-Plough Corporation Method for treating allergic reactions with forskolin
US4564626A (en) * 1983-04-01 1986-01-14 Schering Corporation Methods of inducing bronchodilation
DE3314999A1 (de) * 1983-04-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verwendung des diterpen-derivates forskolin zur immunstimulation
US4476140A (en) * 1983-05-16 1984-10-09 Yale University Composition and method for treatment of glaucoma
US4751224A (en) * 1983-07-21 1988-06-14 Brown University Research Foundation Treatment of metastasis
WO1985003637A1 (en) * 1984-02-24 1985-08-29 Halprin Kenneth M Methods and pharmaceutical compositions for the treatment of hyperplastic diseases of the skin
US4783457A (en) * 1984-05-01 1988-11-08 The General Hospital Corporation Pest controlling agents
US4678775A (en) * 1984-05-01 1987-07-07 Nathanson James A Method of controlling pests
SE454051B (sv) * 1984-10-09 1988-03-28 Marcus Lindblom Som bergdubb tjenande fasthallningsorgan
MC1710A1 (fr) * 1984-11-26 1986-09-22 Ciba Geigy Ag Composes azotes de derives oxo
DE3502686A1 (de) * 1985-01-26 1986-08-14 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von labdan-derivaten und ihre verwendung als arzneimittel
US4672115A (en) * 1984-12-14 1987-06-09 Hoechst-Roussel Pharmaceuticals Inc. Process for preparing aminoacyllabdanes
US4639446A (en) * 1984-12-14 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes, pharmaceutical compositions and use
US4673752A (en) * 1984-12-14 1987-06-16 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes
DE3581725D1 (de) * 1984-12-14 1991-03-14 Hoechst Roussel Pharma Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3502685A1 (de) * 1985-01-26 1986-09-04 Hoechst Ag, 6230 Frankfurt Forskolin, seine analoge und derivate, verfahren zu deren herstellung mittels mikrobieller umwandlungen und die anwendung dieser verbindungen als arzneimittel
US4963537A (en) * 1985-03-01 1990-10-16 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use
IN163242B (es) 1985-05-03 1988-08-27 Hoechst India
AU591196B2 (en) * 1985-11-15 1989-11-30 Nippon Kayaku Kabushiki Kaisha Novel forskolin derivatives
US4734513A (en) * 1986-03-31 1988-03-29 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US5008407A (en) * 1986-03-31 1991-04-16 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US5247097A (en) * 1986-08-28 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Oxolabdanes
US4740522A (en) * 1986-08-28 1988-04-26 Hoechst-Roussel Pharmaceuticals Inc. Oxolabdanes useful as pharmaceuticals for reducing intraocular pressure
US4871764A (en) * 1986-11-20 1989-10-03 Hoechst-Roussel Pharmaceuticals, Inc. 12-Halogenated forskolin derivatives
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US5646175A (en) * 1987-12-28 1997-07-08 Hoechst Marion Roussel, Inc. Carbamoyloxylabdane compounds
US4920146A (en) * 1986-12-29 1990-04-24 Hoechst Roussel Pharmaceuticals Inc. Carbamoyloxylabdane compounds useful in reducing intraocular pressure
US4770376A (en) * 1987-03-19 1988-09-13 Lindblom Erik M Fastener device which functions as a rock dowel
DE3730748A1 (de) * 1987-06-06 1988-12-22 Hoechst Ag Neue polyoxygenierte labdanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPH0739408B2 (ja) * 1987-06-29 1995-05-01 日本化薬株式会社 ６−アシルー７ーデアセチルフオルスコリン誘導体の新規製造法
US5302730A (en) * 1987-06-29 1994-04-12 Nippon Kayaku Kk Process for the preparation of 6,7-diacyl-7-deacetylforskolin derivatives
US4909799A (en) * 1987-09-18 1990-03-20 Olav Thulesius Methods for preventing thrombosis; and surgical implant having reduced platelet deposition characteristics
US4902696A (en) * 1987-10-08 1990-02-20 Hoechst-Roussel Pharmaceuticals, Inc. Synergistic intraocular pressure lowering combinations
US5846992A (en) * 1987-10-08 1998-12-08 Hoechst Marion Roussel, Inc. Synergistic intraocular pressure lowering combinations
US4883793A (en) * 1988-05-09 1989-11-28 Hoechst-Roussel Pharmaceuticals Inc. Hydrazinocarbonyloxylabdanes for treating cardiac failure
EP0370379B1 (en) * 1988-11-19 1992-09-09 Hoechst Aktiengesellschaft Pharmaceutical compositions comprising labdane diterpenoid derivatives and pyrimido(6,1-a) isoquinolin-4-one derivatives and their use
US5177207A (en) * 1989-01-11 1993-01-05 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
US4999351A (en) * 1989-01-11 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
US5093336A (en) * 1989-07-06 1992-03-03 Hoechat-Roussel Pharmaceuticals, Inc. 6- and 7-deoxyforskolin and derivatives thereof
US5145855A (en) * 1989-07-06 1992-09-08 Hoechst Roussel Pharmaceuticals, Inc. 6- and 7-deoxyforskolin and derivatives thereof
JP3557095B2 (ja) * 1998-04-20 2004-08-25 高砂香料工業株式会社 メラニン産生抑制剤
ES2291333T3 (es) 2000-06-27 2008-03-01 Qualilife Pharmaceuticals Inc. Composiciones y metodos para el tratamiento de la respuesta sexual de las mujeres.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631039A (en) * 1969-04-21 1971-12-28 Hoffmann La Roche 2-amino ethyl-2-hydroxy - 6-vinyl tetrahydropyrans tautomers and optical enantiomers thereof

Also Published As

Publication number Publication date
DE2654796A1 (de) 1978-06-08
DK55377A (da) 1978-06-04
IT1075566B (it) 1985-04-22
FI770401A7 (fi) 1978-06-04
NO770401L (no) 1978-06-06
JPS5371077A (en) 1978-06-24
NL7702129A (nl) 1978-06-06
FR2372822A1 (fr) 1978-06-30
ZA771052B (en) 1978-02-22
SE7701310L (sv) 1978-06-04
BE852060A (fr) 1977-09-05
FR2372822B1 (es) 1980-02-01
US4134986A (en) 1979-01-16

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