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ES447349A1 - A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 8-AZAPROSTANOICACIDE. - Google Patents

A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 8-AZAPROSTANOICACIDE.

Info

Publication number
ES447349A1
ES447349A1 ES447349A ES447349A ES447349A1 ES 447349 A1 ES447349 A1 ES 447349A1 ES 447349 A ES447349 A ES 447349A ES 447349 A ES447349 A ES 447349A ES 447349 A1 ES447349 A1 ES 447349A1
Authority
ES
Spain
Prior art keywords
formula
procedure
preparation
defined above
see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES447349A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5090775A external-priority patent/JPS51127068A/en
Priority claimed from JP5293075A external-priority patent/JPS51128961A/en
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES447349A1 publication Critical patent/ES447349A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A procedure for the preparation of new derivatives of 8-azaprostanoic acid of formula: **(See formula)** where R1 is hydrogen or ethyl and R3 is hydrogen or R1 and R3 are methyl, and pharmaceutically acceptable salts thereof, consisting of condensing a compound of formula: **(See formula)** where R4 is lower alkyl, with a compound of the formula: **(See formula)** where R1 and R3 are as defined above, Y is a group of formula (R5O) OPCH2- or (C6H5) 3P = CH- and R5 is lower alkyl; reduce the resulting compound of formula: **(See formula)** where R1, R3 and R4 are as defined above, with an alkali metal borohydride to give a 15-hydroxy-8-azaprostanoate derivative of the formula: **(See formula)** where R1, R3 and R4 are as defined above and then hydrolyze the 15-hydroxy-8-azaprostanoate derivative thus obtained. (Machine-translation by Google Translate, not legally binding)
ES447349A 1975-04-26 1976-04-26 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 8-AZAPROSTANOICACIDE. Expired ES447349A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5090775A JPS51127068A (en) 1975-04-26 1975-04-26 A process for preparing 8-azaprostanoic acid derivatives.
JP5293075A JPS51128961A (en) 1975-04-30 1975-04-30 Process for preparing 8-azaprostanoic acid derivatives

Publications (1)

Publication Number Publication Date
ES447349A1 true ES447349A1 (en) 1977-11-01

Family

ID=26391396

Family Applications (1)

Application Number Title Priority Date Filing Date
ES447349A Expired ES447349A1 (en) 1975-04-26 1976-04-26 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 8-AZAPROSTANOICACIDE.

Country Status (9)

Country Link
AT (1) AT350745B (en)
AU (1) AU1337876A (en)
DE (1) DE2618176A1 (en)
DK (1) DK187276A (en)
ES (1) ES447349A1 (en)
FR (1) FR2354765A1 (en)
GB (1) GB1523178A (en)
NL (1) NL7604437A (en)
SE (1) SE7604714L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113873A (en) 1975-04-26 1978-09-12 Tanabe Seiyaku Co. Ltd. 8-azaprostanoic acid derivatives
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds

Also Published As

Publication number Publication date
FR2354765B1 (en) 1978-10-20
FR2354765A1 (en) 1978-01-13
GB1523178A (en) 1978-08-31
DE2618176A1 (en) 1976-11-04
AT350745B (en) 1979-06-11
SE7604714L (en) 1976-10-27
AU1337876A (en) 1977-11-03
NL7604437A (en) 1976-10-28
ATA301776A (en) 1978-11-15
DK187276A (en) 1976-10-27

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