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ES435935A1 - A PROCEDURE FOR THE PREPARATION OF BENZO-DIACEPINE DERIVATIVES. - Google Patents

A PROCEDURE FOR THE PREPARATION OF BENZO-DIACEPINE DERIVATIVES.

Info

Publication number
ES435935A1
ES435935A1 ES435935A ES435935A ES435935A1 ES 435935 A1 ES435935 A1 ES 435935A1 ES 435935 A ES435935 A ES 435935A ES 435935 A ES435935 A ES 435935A ES 435935 A1 ES435935 A1 ES 435935A1
Authority
ES
Spain
Prior art keywords
formula
preparation
derivatives
diacepine
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435935A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES435935A1 publication Critical patent/ES435935A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A process for the preparation of benzodiazepine derivatives, of the formula ** (see formula) ** In which R means hydrogen or alkyl, R1 means hydrogen, halogen or trifluoromethyl and R2 signifies phenyl, halophenyl or pyridyl, And its 4-oxides, characterized by reacting a benzophenone of the general formula ** (see formula) ** In which R, r1 and r2 have the meaning indicated above, with a nitroacetic acid halide, to reduce the nitroacetyl compound obtained from the general formula ** (see formula) ** In which R, r1 and r2 have the meaning indicated above, the corresponding derivative of hydroxylamine or amine and cyclize the product thus obtained. (Machine-translation by Google Translate, not legally binding)
ES435935A 1974-03-25 1975-03-24 A PROCEDURE FOR THE PREPARATION OF BENZO-DIACEPINE DERIVATIVES. Expired ES435935A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH414974A CH596173A5 (en) 1974-03-25 1974-03-25 CNS Depressant 5-aryl-benzodiazepine prepn.

Publications (1)

Publication Number Publication Date
ES435935A1 true ES435935A1 (en) 1976-12-16

Family

ID=4270728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435935A Expired ES435935A1 (en) 1974-03-25 1975-03-24 A PROCEDURE FOR THE PREPARATION OF BENZO-DIACEPINE DERIVATIVES.

Country Status (12)

Country Link
JP (1) JPS50130777A (en)
AT (1) AT351545B (en)
CA (1) CA1055491A (en)
CH (1) CH596173A5 (en)
DD (1) DD118644A5 (en)
DK (1) DK123675A (en)
ES (1) ES435935A1 (en)
FI (1) FI750380A7 (en)
NL (1) NL7502283A (en)
NO (1) NO751008L (en)
SE (1) SE7503301L (en)
YU (1) YU57775A (en)

Also Published As

Publication number Publication date
AT351545B (en) 1979-07-25
NO751008L (en) 1975-09-26
FI750380A7 (en) 1975-09-26
SE7503301L (en) 1975-09-26
YU57775A (en) 1982-05-31
DD118644A5 (en) 1976-03-12
ATA224775A (en) 1979-01-15
NL7502283A (en) 1975-09-29
JPS50130777A (en) 1975-10-16
CA1055491A (en) 1979-05-29
CH596173A5 (en) 1978-02-28
DK123675A (en) 1975-09-26

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