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ES411826A1 - Process for preparing pharmacologically active 1-aryloxy-2- propanolamines - Google Patents

Process for preparing pharmacologically active 1-aryloxy-2- propanolamines

Info

Publication number
ES411826A1
ES411826A1 ES411826A ES411826A ES411826A1 ES 411826 A1 ES411826 A1 ES 411826A1 ES 411826 A ES411826 A ES 411826A ES 411826 A ES411826 A ES 411826A ES 411826 A1 ES411826 A1 ES 411826A1
Authority
ES
Spain
Prior art keywords
propanolamines
aryloxy
pharmacologically active
chloroform
radicals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES411826A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Liade SA
Original Assignee
Laboratorios Liade SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Liade SA filed Critical Laboratorios Liade SA
Priority to ES411826A priority Critical patent/ES411826A1/en
Priority to GB5057373A priority patent/GB1441976A/en
Priority to FR7342192A priority patent/FR2218094B1/fr
Priority to BE138389A priority patent/BE808066A/en
Priority to DE2359926A priority patent/DE2359926C3/en
Priority to NL7317220A priority patent/NL7317220A/xx
Publication of ES411826A1 publication Critical patent/ES411826A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for obtaining pharmacologically active 1-aryloxy-2-propanolamines, which respond to the formula: ** (See formula) ** in which the radicals R1 and R2 that are attached to the aromatic ring can be respectively and at the same time (see graph) And as for the radicals R'and R''bound to nitrogen in each of the compounds respectively and at the same time: (see graph) whose procedure is characterized in that a phenol is reacted with epichlorohydrin, in the presence of catalysts at a temperature ranging from 70-100º for a time that can vary between 10-20 hours, the reaction mixture is treated with a hydroxide solution sodium for 24 hours; it is extracted with chloroform, the chloroform is removed in vacuo and the residue is distilled under reduced pressure and because in the second phase of the reaction the amine is dissolved in the glycidyl ether obtained in the first phase, dissolved in ethanol or tetrahydrofuran. corresponding to each case. (Machine-translation by Google Translate, not legally binding)
ES411826A 1973-02-20 1973-02-20 Process for preparing pharmacologically active 1-aryloxy-2- propanolamines Expired ES411826A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES411826A ES411826A1 (en) 1973-02-20 1973-02-20 Process for preparing pharmacologically active 1-aryloxy-2- propanolamines
GB5057373A GB1441976A (en) 1973-02-20 1973-10-31 Process for preparing pharmacologically active 1-aryloxy-2- propanolamines
FR7342192A FR2218094B1 (en) 1973-02-20 1973-11-27
BE138389A BE808066A (en) 1973-02-20 1973-11-30 1-ARYLOXY-2-PROPANOLAMINES
DE2359926A DE2359926C3 (en) 1973-02-20 1973-12-01 1-Phenoxy-2-propanolamines, processes for their preparation and pharmaceuticals containing them
NL7317220A NL7317220A (en) 1973-02-20 1973-12-14

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES411826A ES411826A1 (en) 1973-02-20 1973-02-20 Process for preparing pharmacologically active 1-aryloxy-2- propanolamines

Publications (1)

Publication Number Publication Date
ES411826A1 true ES411826A1 (en) 1976-01-01

Family

ID=8463472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES411826A Expired ES411826A1 (en) 1973-02-20 1973-02-20 Process for preparing pharmacologically active 1-aryloxy-2- propanolamines

Country Status (6)

Country Link
BE (1) BE808066A (en)
DE (1) DE2359926C3 (en)
ES (1) ES411826A1 (en)
FR (1) FR2218094B1 (en)
GB (1) GB1441976A (en)
NL (1) NL7317220A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2623314C2 (en) * 1976-05-25 1984-08-02 Hoechst Ag, 6230 Frankfurt 1-aryloxy-2-hydroxy-3-aminopropanes, processes for their preparation and pharmaceuticals containing them
DE2824764A1 (en) * 1978-06-06 1979-12-20 Hoechst Ag NEW PYRIDYL PIPERAZINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
EP0252007A3 (en) * 1986-06-28 1989-07-05 Ciba-Geigy Ag 2-propanol derivatives as corrosion inhibitors
JP6196551B2 (en) * 2010-04-12 2017-09-13 スパーナス ファーマシューティカルズ インコーポレイテッド Process for producing viloxazine salts and novel polymorphs thereof
FR3030514A1 (en) * 2014-12-18 2016-06-24 Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad) POLYAROMATIC DIMERS
CZ309081B6 (en) * 2019-11-21 2022-01-19 Fakultní nemocnice Hradec Králové 1-Aryloxy-3- (4- (2-hydroxyethyl) piperazin-1-yl) propan-2-oly, preparation process and use
CZ310541B6 (en) * 2024-05-30 2025-11-05 Fakultní nemocnice Hradec Králové Derivatives of 1-(4-(2-hydroxyethyl)piperazin-1-yl)-3-phenoxypropan-2-ol, method of their preparation and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524851A (en) * 1966-10-21 1970-08-18 Merck & Co Inc 1-phenoxy-3-morpholino alkylamino-2-propanols

Also Published As

Publication number Publication date
DE2359926C3 (en) 1980-05-22
FR2218094A1 (en) 1974-09-13
BE808066A (en) 1974-03-15
NL7317220A (en) 1974-08-22
DE2359926B2 (en) 1979-08-23
FR2218094B1 (en) 1977-07-01
GB1441976A (en) 1976-07-07
DE2359926A1 (en) 1974-08-29

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