ES400000A1 - Procedure for obtaining 1-ariloxy-2-propanolaminas pharmacologically active. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining 1-ariloxy-2-propanolaminas pharmacologically active. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES400000A1 ES400000A1 ES400000A ES400000A ES400000A1 ES 400000 A1 ES400000 A1 ES 400000A1 ES 400000 A ES400000 A ES 400000A ES 400000 A ES400000 A ES 400000A ES 400000 A1 ES400000 A1 ES 400000A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- phase
- translation
- chloroform
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003208 petroleum Substances 0.000 abstract 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000002924 oxiranes Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
Procedure for obtaining pharmacologically active 1-aryloxy-2-propanolamines, which respond to the general formula: **(See formula)** in which the radicals R1, R2 and R3 that are attached to the aromatic ring can be respectively and at the same time: (see graph) and as for the radicals R'and R''bound to nitrogen, in each of the compounds they are respectively and at the same time: (see graph) whose procedure is characterized in that the reaction is carried out in two phases; in the first phase, a phenol in an alkaline medium is reacted with 1-chloro-2,3-epoxypropane at a temperature ranging from -5 to 50ºC; the reaction mixture is extracted with chloroform or another organic solvent; the chloroform solution is acidified with acetic acid and washed with water, the chloroform is removed and the obtained intermediate compound is distilled under vacuum or crystallized from petroleum ether, petroleum ether-ether or alcohol and because in the second phase of the reaction add to the epoxide obtained in the first phase, dissolved in ethanol, tetrahydofuran, the amine corresponding to each case. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES400000A ES400000A1 (en) | 1972-02-19 | 1972-02-19 | Procedure for obtaining 1-ariloxy-2-propanolaminas pharmacologically active. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES400000A ES400000A1 (en) | 1972-02-19 | 1972-02-19 | Procedure for obtaining 1-ariloxy-2-propanolaminas pharmacologically active. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES400000A1 true ES400000A1 (en) | 1975-01-01 |
Family
ID=8460363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES400000A Expired ES400000A1 (en) | 1972-02-19 | 1972-02-19 | Procedure for obtaining 1-ariloxy-2-propanolaminas pharmacologically active. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES400000A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1465488A4 (en) * | 2001-08-30 | 2007-04-18 | Chemocentryx Inc | Arylamines as inhibitors of chemokine binding to us28 |
-
1972
- 1972-02-19 ES ES400000A patent/ES400000A1/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1465488A4 (en) * | 2001-08-30 | 2007-04-18 | Chemocentryx Inc | Arylamines as inhibitors of chemokine binding to us28 |
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