ES419195A1 - PROCEDURE FOR OBTAINING DERIVATIVES OF LENZ (F) ISOINDOLINE. - Google Patents
PROCEDURE FOR OBTAINING DERIVATIVES OF LENZ (F) ISOINDOLINE.Info
- Publication number
- ES419195A1 ES419195A1 ES419195A ES419195A ES419195A1 ES 419195 A1 ES419195 A1 ES 419195A1 ES 419195 A ES419195 A ES 419195A ES 419195 A ES419195 A ES 419195A ES 419195 A1 ES419195 A1 ES 419195A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- optical antipodes
- procedure
- isoindoline
- definition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical compound C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title 1
- 230000003287 optical effect Effects 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HKCSQKNVNWPECI-UHFFFAOYSA-N 2,3-dihydro-1h-benzo[f]isoindole Chemical class C1=CC=C2C=C3CNCC3=CC2=C1 HKCSQKNVNWPECI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedure for obtaining benz [F] isoindoline derivatives of formula Ib, **(See formula)** which, according to the definition, also comprises the optical antipodes of these compounds of formula Ib as well as the racemic mixtures of these optical antipodes, in which formula R1 and R2 which are the same or different, each represent hydrogen, halogen or alkyl of 1 to 4 carbon atoms, each of X and Y being hydrogen, in which case rings B and C are linked by a cis bond, or X and Y together form an additional bond, and their acid addition salts ; characterized by comprising: separate group R9, from a compound of formula VI: **(See formula)** which, according to the definition, also includes the optical antipodes of the compounds of formula VI as well as the racemic mixtures of the optical antipodes, and in which formula R1, R2, X and Y are defined as above and R9 is an attractive group of electrodes, conveniently in a solvent, preferably between room temperature and reflux temperature. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1425072A CH590231A5 (en) | 1972-09-29 | 1972-09-29 | Benzo(f)isoindoline derivs - with antidepressant and analgesic activity |
| CH1130573A CH605748A5 (en) | 1973-08-03 | 1973-08-03 | Benzo(f)isoindoline derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES419195A1 true ES419195A1 (en) | 1976-12-16 |
Family
ID=25708104
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES419195A Expired ES419195A1 (en) | 1972-09-29 | 1973-09-29 | PROCEDURE FOR OBTAINING DERIVATIVES OF LENZ (F) ISOINDOLINE. |
| ES443517A Expired ES443517A1 (en) | 1972-09-29 | 1975-12-16 | PROCEDURE FOR THE DRAWING OF DERIVATIVES OF BENZ (F) ISO-INDOLINA. |
| ES443518A Expired ES443518A1 (en) | 1972-09-29 | 1975-12-16 | PROCEDURE FOR OBTAINING DERIVATIVES OF BENZ (F) ISOINDOLINE. |
| ES443519A Expired ES443519A1 (en) | 1972-09-29 | 1975-12-16 | PROCEDURE FOR OBTAINING DERIVATIVES OF BENZ (F) I- SOINDOLINE. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443517A Expired ES443517A1 (en) | 1972-09-29 | 1975-12-16 | PROCEDURE FOR THE DRAWING OF DERIVATIVES OF BENZ (F) ISO-INDOLINA. |
| ES443518A Expired ES443518A1 (en) | 1972-09-29 | 1975-12-16 | PROCEDURE FOR OBTAINING DERIVATIVES OF BENZ (F) ISOINDOLINE. |
| ES443519A Expired ES443519A1 (en) | 1972-09-29 | 1975-12-16 | PROCEDURE FOR OBTAINING DERIVATIVES OF BENZ (F) I- SOINDOLINE. |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS602304B2 (en) |
| AT (1) | AT339891B (en) |
| CA (1) | CA1008865A (en) |
| DD (2) | DD118630A5 (en) |
| DE (1) | DE2348593A1 (en) |
| DK (1) | DK136420B (en) |
| ES (4) | ES419195A1 (en) |
| FI (1) | FI57748C (en) |
| FR (1) | FR2201092B1 (en) |
| GB (1) | GB1449159A (en) |
| HK (1) | HK380A (en) |
| IE (1) | IE39474B1 (en) |
| IL (1) | IL43333A (en) |
| MY (1) | MY8000220A (en) |
| NL (1) | NL7313111A (en) |
| PH (1) | PH12933A (en) |
| SE (1) | SE394110B (en) |
| SU (1) | SU707521A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860878D1 (en) * | 1977-06-28 | 1981-10-29 | Sandoz Ag | New benz(f)isoindolines, their preparation and medicaments containing them |
| FR2791345B1 (en) * | 1999-03-26 | 2001-05-04 | Adir | NOVEL BENZO [3,4] CYCLOBUTA [1,2-C] PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792374A (en) * | 1971-12-08 | 1973-06-06 | Allen & Hanburys Ltd | NEW DERIVATIVES OF ISOINDOLINE |
-
1973
- 1973-09-20 FI FI2934/73A patent/FI57748C/en active
- 1973-09-20 DK DK516373AA patent/DK136420B/en not_active IP Right Cessation
- 1973-09-21 SE SE7312916A patent/SE394110B/en unknown
- 1973-09-24 NL NL7313111A patent/NL7313111A/xx not_active Application Discontinuation
- 1973-09-26 DD DD187137*A patent/DD118630A5/xx unknown
- 1973-09-26 IL IL43333A patent/IL43333A/en unknown
- 1973-09-26 DD DD173691A patent/DD114604A5/xx unknown
- 1973-09-27 DE DE19732348593 patent/DE2348593A1/en not_active Withdrawn
- 1973-09-27 IE IE1730/73A patent/IE39474B1/en unknown
- 1973-09-28 AT AT833873A patent/AT339891B/en not_active IP Right Cessation
- 1973-09-28 JP JP48108577A patent/JPS602304B2/en not_active Expired
- 1973-09-28 FR FR7334863A patent/FR2201092B1/fr not_active Expired
- 1973-09-28 CA CA182,178A patent/CA1008865A/en not_active Expired
- 1973-09-28 GB GB4547773A patent/GB1449159A/en not_active Expired
- 1973-09-29 ES ES419195A patent/ES419195A1/en not_active Expired
- 1973-10-01 PH PH15069A patent/PH12933A/en unknown
-
1975
- 1975-12-16 ES ES443517A patent/ES443517A1/en not_active Expired
- 1975-12-16 ES ES443518A patent/ES443518A1/en not_active Expired
- 1975-12-16 ES ES443519A patent/ES443519A1/en not_active Expired
-
1976
- 1976-10-28 SU SU762415454A patent/SU707521A3/en active
-
1980
- 1980-01-03 HK HK3/80A patent/HK380A/en unknown
- 1980-12-30 MY MY220/80A patent/MY8000220A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI57748B (en) | 1980-06-30 |
| IL43333A (en) | 1978-10-31 |
| IE39474B1 (en) | 1978-10-25 |
| DD114604A5 (en) | 1975-08-12 |
| DK136420C (en) | 1978-03-13 |
| IE39474L (en) | 1974-03-29 |
| CA1008865A (en) | 1977-04-19 |
| AT339891B (en) | 1977-11-10 |
| GB1449159A (en) | 1976-09-15 |
| SU707521A3 (en) | 1979-12-30 |
| DD118630A5 (en) | 1976-03-12 |
| SE394110B (en) | 1977-06-06 |
| NL7313111A (en) | 1974-04-02 |
| IL43333A0 (en) | 1973-11-28 |
| ES443517A1 (en) | 1977-08-16 |
| FR2201092A1 (en) | 1974-04-26 |
| ES443519A1 (en) | 1977-08-16 |
| MY8000220A (en) | 1980-12-31 |
| DK136420B (en) | 1977-10-10 |
| ATA833873A (en) | 1977-02-15 |
| FI57748C (en) | 1980-10-10 |
| JPS4970960A (en) | 1974-07-09 |
| PH12933A (en) | 1979-10-17 |
| FR2201092B1 (en) | 1977-09-09 |
| JPS602304B2 (en) | 1985-01-21 |
| DE2348593A1 (en) | 1974-04-11 |
| HK380A (en) | 1980-01-11 |
| AU6085273A (en) | 1975-04-10 |
| ES443518A1 (en) | 1977-08-01 |
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