ES416973A1 - Procedure for the preparation of derivatives of 1,8-naftiridina. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of derivatives of 1,8-naftiridina. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES416973A1 ES416973A1 ES416973A ES416973A ES416973A1 ES 416973 A1 ES416973 A1 ES 416973A1 ES 416973 A ES416973 A ES 416973A ES 416973 A ES416973 A ES 416973A ES 416973 A1 ES416973 A1 ES 416973A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- aryl
- preparation
- alkyl
- acylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000005058 1,8-naphthyridines Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- WCZVZNOTHYJIEI-UHFFFAOYSA-N cinnoline Chemical group N1=NC=CC2=CC=CC=C21 WCZVZNOTHYJIEI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for the preparation of 1,8-naphthyridine derivatives and, more particularly, for the preparation of compounds of formula I **(See formula)** and tautomers and acid addition salts thereof, in which R1 and R2 are the same or different and signify hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, amino, acylamino, alkylamino, dialkylamino, a nitrogen-containing heterocyclic monocyclic group, which is attached to the diazanaphthalene group through its nitrogen, acyl, alkoxycarbonylalkyl, alkoxycarbonyl or other carboxylic acid derived group; R3 signifies alkyl, aryl, aralkyl, hydroxyl, alkoxy, amino, acylamino or halogen; R4 signifies hydrogen or an alkyl, aryl, aralkyl, halogen, nitro, alkoxy, hydroxy, amino, acylamino or carboxylic acid derivative group; characterized in that it comprises subjecting a compound of formula II **(See formula)** in which R1, R2, R3 and R4 are as indicated above, to isomerization and eventually converting the compound of formula I thus obtained to its tautomer into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUME001512 HU165405B (en) | 1972-06-29 | 1972-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES416973A1 true ES416973A1 (en) | 1976-03-16 |
Family
ID=10999288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES416973A Expired ES416973A1 (en) | 1972-06-29 | 1973-06-30 | Procedure for the preparation of derivatives of 1,8-naftiridina. (Machine-translation by Google Translate, not legally binding) |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS527000B2 (en) |
| BE (1) | BE801669A (en) |
| CS (1) | CS184873B1 (en) |
| ES (1) | ES416973A1 (en) |
| FR (1) | FR2190820B1 (en) |
| GB (1) | GB1432967A (en) |
| HU (1) | HU165405B (en) |
| SU (1) | SU479294A3 (en) |
| YU (1) | YU175973A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644825A1 (en) * | 1986-12-31 | 1988-07-14 | Basf Ag | SUBSTITUTED 1,8-NAPHTHYRIDINE DERIVATIVES AND FUNGICIDES CONTAINING THEM |
| EP1104420B1 (en) * | 1998-08-11 | 2002-12-18 | Pfizer Products Inc. | Substituted 1,8-naphthyridin-4(1h)-ones as phosphodiesterase 4 inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH66A (en) * | 1889-01-08 | J Kobler | Firelighter |
-
1972
- 1972-06-29 HU HUME001512 patent/HU165405B/hu not_active IP Right Cessation
-
1973
- 1973-06-27 SU SU1951080A patent/SU479294A3/en active
- 1973-06-28 GB GB3089973A patent/GB1432967A/en not_active Expired
- 1973-06-28 JP JP48073235A patent/JPS527000B2/ja not_active Expired
- 1973-06-29 CS CS474873A patent/CS184873B1/en unknown
- 1973-06-29 BE BE132909A patent/BE801669A/en not_active IP Right Cessation
- 1973-06-29 FR FR7323957A patent/FR2190820B1/fr not_active Expired
- 1973-06-30 ES ES416973A patent/ES416973A1/en not_active Expired
- 1973-07-28 YU YU175973A patent/YU175973A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2190820B1 (en) | 1976-06-18 |
| FR2190820A1 (en) | 1974-02-01 |
| SU479294A3 (en) | 1975-07-30 |
| JPS527000B2 (en) | 1977-02-26 |
| YU175973A (en) | 1982-05-31 |
| JPS4962498A (en) | 1974-06-17 |
| BE801669A (en) | 1973-10-15 |
| GB1432967A (en) | 1976-04-22 |
| HU165405B (en) | 1974-08-28 |
| CS184873B1 (en) | 1978-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19870713 |