ES402749A1 - A PROCEDURE FOR THE PREPARATION OF TIENO-DIACEPINE DERIVATIVES. - Google Patents

Abstract

A procedure for the preparation of thienodiazepine derivatives, of the general formula **(See formula)** in which R1 represents a halogen atom or a nitro group; R2 represents a hydrogen atom or a group of the formula -CH2-X (where X represents a hydrogen atom or an alkyl, alkenyl or cycloalkyl group containing at most 4 carbon atoms, a hydroxymethyl or methoxy group or a dialkylaminomethyl group including a total of 5 carbon atoms at most); and R3 represents a group of o-halophenyl, o-trifluoromethylphenyl or o, o'-dihalophenyl or, when R1 represents a halogen atom, R3 can also represent a group of o-nitrophenyl, and its salts, characterized by: a) appropriately substituting a compound of the general formula in which R2 and R3 have the same meaning as previously attributed to them in this claim, in position 7; O well b) cyclizing a compound of the general formula **(See formula)** in which R1, R2 and R3 have the same meaning as attributed earlier in this claim; O well c) for the formation of a compound of the formula I in which R2 represents a group of the formula -CH2-X, appropriately substitute a compound of the general formula **(See formula)** in which R1 and R3 have the same meaning as attributed earlier in this claim, in position 1; and d) if desired, convert a compound obtained into a salt. (Machine-translation by Google Translate, not legally binding)