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ES402672A1 - A PROCEDURE FOR THE TRANSPOSITION OF A SULFOXIDE FROM 6-ACILAMIDOPENICILANICO ACID TO 7-ACILAMIDO-3-METTILCEF-3-EM-4-CARBOXILICO. - Google Patents

A PROCEDURE FOR THE TRANSPOSITION OF A SULFOXIDE FROM 6-ACILAMIDOPENICILANICO ACID TO 7-ACILAMIDO-3-METTILCEF-3-EM-4-CARBOXILICO.

Info

Publication number
ES402672A1
ES402672A1 ES402672A ES402672A ES402672A1 ES 402672 A1 ES402672 A1 ES 402672A1 ES 402672 A ES402672 A ES 402672A ES 402672 A ES402672 A ES 402672A ES 402672 A1 ES402672 A1 ES 402672A1
Authority
ES
Spain
Prior art keywords
acid
sulfoxide
transposition
procedure
mettilcef
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES402672A
Other languages
Spanish (es)
Inventor
J Rubinfeld
R Lemiuex
R Raap
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES402672A1 publication Critical patent/ES402672A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/08—Preparation by forming the ring or condensed ring systems
    • C07D501/10—Preparation by forming the ring or condensed ring systems from compounds containing the penicillin ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fodder In General (AREA)

Abstract

A procedure for the transposition of a 6-acylamidopenicillanico acid sulfoxide to 7-acilamido3-methylcef-3-em-4-carboxylic acid by heating said phenycylanic acid sulfoxide in the presence of an acid catalyst, whose process is characterized by heating the acid form free from 6-acylamidopenicillanic acid sulfoxide in a weakly basic solvent, in the presence of a catalyst comprising a strong acid either alone or in combination with a nitrogenous base with a pKb of not less than 4. (Machine-translation by Google Translate, not legally binding)
ES402672A 1971-05-11 1972-05-12 A PROCEDURE FOR THE TRANSPOSITION OF A SULFOXIDE FROM 6-ACILAMIDOPENICILANICO ACID TO 7-ACILAMIDO-3-METTILCEF-3-EM-4-CARBOXILICO. Expired ES402672A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00143683A US3843637A (en) 1971-05-11 1971-05-11 Process for rearranging 6-acylamidopenicillanic acid-1-oxides to 7-acyla mido-3-methyl-ceph-3-em-4-carboxylic acids

Publications (1)

Publication Number Publication Date
ES402672A1 true ES402672A1 (en) 1975-10-16

Family

ID=22505135

Family Applications (3)

Application Number Title Priority Date Filing Date
ES402672A Expired ES402672A1 (en) 1971-05-11 1972-05-12 A PROCEDURE FOR THE TRANSPOSITION OF A SULFOXIDE FROM 6-ACILAMIDOPENICILANICO ACID TO 7-ACILAMIDO-3-METTILCEF-3-EM-4-CARBOXILICO.
ES430116A Expired ES430116A1 (en) 1971-05-11 1974-09-16 AN IMPROVED PROCEDURE FOR THE PREPARATION OF CEFALEXINAY AND NON-TOXIC AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE MIS-MA.
ES430117A Expired ES430117A1 (en) 1971-05-11 1974-09-16 Process for rearranging 6-acylamidopenicillanic acid-1-oxides to 7-acyla mido-3-methyl-ceph-3-em-4-carboxylic acids

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES430116A Expired ES430116A1 (en) 1971-05-11 1974-09-16 AN IMPROVED PROCEDURE FOR THE PREPARATION OF CEFALEXINAY AND NON-TOXIC AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE MIS-MA.
ES430117A Expired ES430117A1 (en) 1971-05-11 1974-09-16 Process for rearranging 6-acylamidopenicillanic acid-1-oxides to 7-acyla mido-3-methyl-ceph-3-em-4-carboxylic acids

Country Status (27)

Country Link
US (1) US3843637A (en)
JP (3) JPS565229B1 (en)
AR (3) AR194364A1 (en)
AT (1) AT325201B (en)
AU (1) AU461358B2 (en)
BE (1) BE783222A (en)
CA (1) CA986096A (en)
CH (1) CH578007A5 (en)
CS (3) CS190399B2 (en)
DD (1) DD99584A5 (en)
DE (1) DE2222953A1 (en)
DK (1) DK140845B (en)
ES (3) ES402672A1 (en)
FI (1) FI58925C (en)
FR (1) FR2143667B1 (en)
GB (1) GB1391838A (en)
HU (2) HU166186B (en)
IE (1) IE36353B1 (en)
IL (1) IL39382A (en)
NL (1) NL7206193A (en)
NO (3) NO146202C (en)
PH (1) PH13518A (en)
PL (3) PL85195B1 (en)
SE (3) SE411045B (en)
SU (2) SU626704A3 (en)
YU (3) YU122672A (en)
ZA (1) ZA723119B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2143211B1 (en) * 1971-06-24 1975-10-31 Fujisawa Pharmaceutical Co
JPS536158B2 (en) * 1972-03-23 1978-03-04
US3960851A (en) * 1972-05-15 1976-06-01 Eli Lilly And Company Preparation of desacetoxy-cephalosporin sulfoxides from penicillin sulfoxides
GB1441587A (en) * 1972-07-14 1976-07-07 Glaxo Lab Ltd Cephalosporin compounds
GB1442785A (en) * 1972-12-09 1976-07-14 Nikken Chemicals Co Ltd Desacetoxy ceaphalosporanic acids
GB1465893A (en) * 1973-02-09 1977-03-02 Gist Brocades Nv I-carboxypropenyl-4-iminothio-azetidine-2-one derivatives methods for their preparation and use
US4010156A (en) * 1973-04-19 1977-03-01 American Home Products Corporation Process for the rearrangement of penicillins to cephalosporins and intermediate compounds thereof
JPS5084591A (en) * 1973-11-29 1975-07-08
US3953440A (en) * 1974-12-13 1976-04-27 Eli Lilly And Company Deacetoxycephalosporins via penicillin sulfoxide rearrangement
US4061862A (en) * 1975-10-06 1977-12-06 Bristol-Myers Company Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin
US4091213A (en) * 1975-12-12 1978-05-23 Bristol-Myers Company 7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives
US4182709A (en) * 1976-01-15 1980-01-08 Glaxo Group Limited Manufacture of semi-synthetic penicillin antibiotics
EP2451643B1 (en) 2009-07-08 2017-08-23 Tetra Laval Holdings & Finance S.A. Non-foil packaging laminate, method for manufacturing of the packaging laminate and packaging container thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725399A (en) * 1969-03-11 1973-04-03 Glaxo Lab Ltd METHOD OF PRODUCING 7{62 -ACYLAMIDO-3-METHYLCEPH-3-Em-4-CARBOXYLIC ACID ESTERS

Also Published As

Publication number Publication date
NO146202C (en) 1982-08-18
NL7206193A (en) 1972-11-14
BE783222A (en) 1972-11-09
IE36353B1 (en) 1976-10-13
DK140845B (en) 1979-11-26
CS190399B2 (en) 1979-05-31
US3843637A (en) 1974-10-22
AT325201B (en) 1975-10-10
JPS565758B2 (en) 1981-02-06
FI58925B (en) 1981-01-30
SE414176B (en) 1980-07-14
NO146241C (en) 1982-08-25
FR2143667B1 (en) 1977-01-28
HU166186B (en) 1975-02-28
NO146202B (en) 1982-05-10
SU662013A3 (en) 1979-05-05
HU165177B (en) 1974-07-27
CH578007A5 (en) 1976-07-30
CS190367B2 (en) 1979-05-31
YU174979A (en) 1983-01-21
IL39382A0 (en) 1972-07-26
SE7414728L (en) 1974-11-22
JPS55108875A (en) 1980-08-21
SE7414727L (en) 1974-11-22
SU626704A3 (en) 1978-09-30
GB1391838A (en) 1975-04-23
AU4187672A (en) 1973-11-08
PH13518A (en) 1980-06-03
AR200720A1 (en) 1974-12-13
IE36353L (en) 1972-11-11
FR2143667A1 (en) 1973-02-09
JPS565229B1 (en) 1981-02-04
ZA723119B (en) 1973-05-30
JPS565759B2 (en) 1981-02-06
SE414177B (en) 1980-07-14
AR197310A1 (en) 1974-03-29
YU122672A (en) 1982-02-28
SE411045B (en) 1979-11-26
ES430116A1 (en) 1976-10-16
PL94780B1 (en) 1977-08-31
PL94030B1 (en) 1977-07-30
DD99584A5 (en) 1973-08-12
NO146241B (en) 1982-05-18
NO146203C (en) 1982-08-18
AU461358B2 (en) 1975-05-22
ES430117A1 (en) 1976-10-16
FI58925C (en) 1981-05-11
PL85195B1 (en) 1976-04-30
NO146203B (en) 1982-05-10
CS190400B2 (en) 1979-05-31
DE2222953A1 (en) 1973-03-01
CA986096A (en) 1976-03-23
JPS55108876A (en) 1980-08-21
DK140845C (en) 1980-05-12
AR194364A1 (en) 1973-07-13
IL39382A (en) 1975-07-28
YU174879A (en) 1983-02-28

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