ES401041A1 - A procedure for the preparation of 17 alpha etinil-stryles. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of 17 alpha etinil-stryles. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES401041A1 ES401041A1 ES401041A ES401041A ES401041A1 ES 401041 A1 ES401041 A1 ES 401041A1 ES 401041 A ES401041 A ES 401041A ES 401041 A ES401041 A ES 401041A ES 401041 A1 ES401041 A1 ES 401041A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- translation
- procedure
- preparation
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 cycloalkyl halide Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of 17α-ethinylestriols of formula II **(See formula)** where R'' is hydrogen, C1-C3 alkyl or C5-C6 cycloalkyl, whose process is characterized by: (1) reacting a mixture of isomers of the following formulas II and III **(See formula)** where R'' is as defined above, with acetone in the presence of an acid to give a compound of formula IV **(See formula)** where R'' has the meaning given above, separating said acetonide by chromatography from the desired compound of formula II and recovering said compound of formula II and, if desired, (2) when R'' is hydrogen, reacting a metal salt of 17α-ethinylestriol with a C5-C6 cycloalkyl halide in dimethylformamide to give the C5-C6 cycloalkyl ether of formula V **(See formula)** where R3 is C5-C6 cycloalkyl. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12769071A | 1971-03-24 | 1971-03-24 | |
| US127771A US3697558A (en) | 1971-03-24 | Preparation of 17alpha-ethynylestriol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES401041A1 true ES401041A1 (en) | 1975-07-01 |
Family
ID=26825881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES401041A Expired ES401041A1 (en) | 1971-03-24 | 1972-03-21 | A procedure for the preparation of 17 alpha etinil-stryles. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES401041A1 (en) |
| HU (2) | HU164892B (en) |
-
1972
- 1972-03-21 ES ES401041A patent/ES401041A1/en not_active Expired
- 1972-03-23 HU HUEI000413 patent/HU164892B/hu unknown
- 1972-03-23 HU HUEI000491 patent/HU165337B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU164892B (en) | 1974-05-28 |
| HU165337B (en) | 1974-08-28 |
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