ES400897A1 - Process for preparing penicillins - Google Patents
Process for preparing penicillinsInfo
- Publication number
- ES400897A1 ES400897A1 ES72400897A ES400897A ES400897A1 ES 400897 A1 ES400897 A1 ES 400897A1 ES 72400897 A ES72400897 A ES 72400897A ES 400897 A ES400897 A ES 400897A ES 400897 A1 ES400897 A1 ES 400897A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- derivative
- acid
- ester
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002960 penicillins Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- 108700023418 Amidases Proteins 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 102000005922 amidase Human genes 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process for the preparation of α-amino-p-hydroribenzylpenicillin (I) or an ester thereof or an α-amino-p-hydroxybenzylcephalosporin (II), the method of which is to couple an acid derivative of the formula: **(See formula)** where X is an amino, alkoxy or alkylthio group, all of which may be substituted, with 6-aminopenicillanic acid or an ester thereof or with 7-aminocephalosporanic acid or a derivative thereof, in the presence of an acylase enzyme or a derivative insoluble in water thereof or in the presence of the bacteria that produce said enzyme. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB714971A GB1367342A (en) | 1972-03-18 | 1972-03-18 | Process for preparing penicillins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES400897A1 true ES400897A1 (en) | 1975-02-01 |
Family
ID=9827558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES72400897A Expired ES400897A1 (en) | 1972-03-18 | 1972-03-17 | Process for preparing penicillins |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES400897A1 (en) |
| GB (1) | GB1367342A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH14681A (en) * | 1977-11-30 | 1981-11-10 | Pfizer | Phenylglycinamides useful in the treatment of ischaemic heart disease |
-
1972
- 1972-03-17 ES ES72400897A patent/ES400897A1/en not_active Expired
- 1972-03-18 GB GB714971A patent/GB1367342A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1367342A (en) | 1974-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3066574D1 (en) | Optically pure heterocyclic amino acids, process for their preparation and their use | |
| ES371709A1 (en) | Synthetic penicillins | |
| ES401263A1 (en) | Penicillin synthesis | |
| ES400897A1 (en) | Process for preparing penicillins | |
| IT1022988B (en) | METHOD FOR PROCEDURES GLUTAMIC ACID BY FERMENTATION | |
| ES384027A1 (en) | A procedure for the production of 6-aminopenicilanico acid. (Machine-translation by Google Translate, not legally binding) | |
| ES412876A1 (en) | Process for the production of succinylosuccinic diesters | |
| ATE91711T1 (en) | PROCESS FOR THE ENZYMATIC HYDROLYSIS OF ALPHA AMINOADIPINYL MONOAMINE COMPOUNDS. | |
| DK143165C (en) | METHOD OF PREPARING 6-AMINOPENICILLANIC ACID BY ENZYMATIC REVERSION OF PENICILLIN WITH A PENICILLINAMIDASE-PRODUCING MICROORGANISM | |
| ES396969A1 (en) | Penicillins | |
| JPS5394093A (en) | Novel process for preparation of 7-amino-cephalosporanic acid and their derivatives | |
| ES419444A1 (en) | Process for the preparation of substituted benzimidazoles | |
| ES410723A1 (en) | ' -aminocycloalkylacetamido penicillanic acids and their salts and esters | |
| GB1114043A (en) | Improvements in or relating to acid compounds and the manufacture thereof by a microbiological method | |
| KR790000350B1 (en) | Process for preparation of 6-di(-) -aminopara-hydroxy phenyl acetamido phenicillanic acid | |
| JPS5272886A (en) | Preparation of cephalosporin compound | |
| ES403290A1 (en) | Procedure for the preparation of penicillin derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES408860A1 (en) | Production of 6-aminopenicillanic acid | |
| ES375066A1 (en) | A procedure for the preparation of acid (-) (cis-1,2 exposipropil) phosphonic. (Machine-translation by Google Translate, not legally binding) | |
| ES381429A1 (en) | Penicillins | |
| ES390235A1 (en) | Process for the production of 6-amino-penicillanic acid derivatives | |
| CS182785B2 (en) | Method for the production of l-lysine by fermentation | |
| ES280828A2 (en) | Procedure for the enzymatic acilation of 6-aminopenicilºnico acid (Machine-translation by Google Translate, not legally binding) | |
| ES394132A1 (en) | Thiadiazolyl amino penicillins | |
| GB1459294A (en) | Isolation of 6-aminopenicillanic acid and salts thereof |