ES408279A1 - Process for the preparation of methylcobalamine - Google Patents
Process for the preparation of methylcobalamineInfo
- Publication number
- ES408279A1 ES408279A1 ES408279A ES408279A ES408279A1 ES 408279 A1 ES408279 A1 ES 408279A1 ES 408279 A ES408279 A ES 408279A ES 408279 A ES408279 A ES 408279A ES 408279 A1 ES408279 A1 ES 408279A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxocobalamin
- methylation
- reduction
- methylcobalamine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 abstract 4
- 235000004867 hydroxocobalamin Nutrition 0.000 abstract 2
- 239000011704 hydroxocobalamin Substances 0.000 abstract 2
- 229960001103 hydroxocobalamin Drugs 0.000 abstract 2
- 230000011987 methylation Effects 0.000 abstract 2
- 238000007069 methylation reaction Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 235000007672 methylcobalamin Nutrition 0.000 abstract 1
- 239000011585 methylcobalamin Substances 0.000 abstract 1
- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Catalysts (AREA)
Abstract
Manufacturing process of methylcobalamin by reduction and methylation of hydroxocobalamin, characterized in that this reduction and this methylation are carried out simultaneously within a hydroalcoholic solution of hydroxocobalamin by the action of a methyl monoester of a carboxylic diacid in the presence of metallic powder. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7140233A FR2159720A5 (en) | 1971-11-10 | 1971-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES408279A1 true ES408279A1 (en) | 1975-11-01 |
Family
ID=9085580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES408279A Expired ES408279A1 (en) | 1971-11-10 | 1972-11-04 | Process for the preparation of methylcobalamine |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS51120B2 (en) |
| AR (1) | AR192677A1 (en) |
| AT (1) | AT330374B (en) |
| AU (1) | AU464986B2 (en) |
| BE (1) | BE789252A (en) |
| BR (1) | BR7207834D0 (en) |
| CA (1) | CA972746A (en) |
| CH (1) | CH545299A (en) |
| DE (1) | DE2255203A1 (en) |
| DK (1) | DK133381B (en) |
| ES (1) | ES408279A1 (en) |
| FR (1) | FR2159720A5 (en) |
| GB (1) | GB1355899A (en) |
| IE (1) | IE36822B1 (en) |
| IL (1) | IL40762A (en) |
| LU (1) | LU66165A1 (en) |
| NL (1) | NL153548B (en) |
| NO (1) | NO137095C (en) |
| OA (1) | OA04191A (en) |
| SE (1) | SE383350B (en) |
| ZA (1) | ZA727831B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO742545L (en) * | 1973-08-08 | 1975-03-10 | Opochimie L | |
| JPS583753Y2 (en) * | 1978-08-25 | 1983-01-22 | 日立造船株式会社 | Connection device for offshore structures |
| JPH0422432A (en) * | 1990-05-18 | 1992-01-27 | Maruyama Mfg Co Ltd | Method and device for agitating spray liquid in spray liquid tank |
| DK1236737T3 (en) * | 1999-12-09 | 2006-06-19 | Eisai Co Ltd | Process for the preparation of methylcobalamin |
| US7220855B2 (en) | 2001-06-05 | 2007-05-22 | Eisai Co., Ltd. | Process for producing methylcobalamin |
| HUE063127T2 (en) * | 2016-07-08 | 2024-01-28 | Healthtech Bio Actives S L U | Process for the purification of methylcobalamin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1178073B (en) * | 1961-06-09 | 1964-09-17 | Merck Ag E | Process for the production of vitamin B and its stable solutions |
| FR1450375A (en) * | 1961-12-11 | 1966-06-24 | Glaxo Group Ltd | Process for the preparation of a coenzyme of vitamin b12 and analogues thereof |
| DE1213842B (en) * | 1962-04-27 | 1966-04-07 | Hoffmann La Roche | Process for the preparation of Co-R cobamides |
-
0
- BE BE789252D patent/BE789252A/en unknown
-
1971
- 1971-11-10 FR FR7140233A patent/FR2159720A5/fr not_active Expired
-
1972
- 1972-09-25 DK DK472172AA patent/DK133381B/en unknown
- 1972-09-26 NO NO3443/72A patent/NO137095C/en unknown
- 1972-09-26 LU LU66165A patent/LU66165A1/xx unknown
- 1972-10-03 OA OA54710A patent/OA04191A/en unknown
- 1972-10-24 NL NL727214368A patent/NL153548B/en unknown
- 1972-11-01 GB GB5032472A patent/GB1355899A/en not_active Expired
- 1972-11-01 SE SE7214155A patent/SE383350B/en unknown
- 1972-11-02 CA CA155,413A patent/CA972746A/en not_active Expired
- 1972-11-02 IE IE1494/72A patent/IE36822B1/en unknown
- 1972-11-03 ZA ZA727831A patent/ZA727831B/en unknown
- 1972-11-04 ES ES408279A patent/ES408279A1/en not_active Expired
- 1972-11-07 AT AT945672A patent/AT330374B/en not_active IP Right Cessation
- 1972-11-07 AU AU48582/72A patent/AU464986B2/en not_active Expired
- 1972-11-07 IL IL40762A patent/IL40762A/en unknown
- 1972-11-08 CH CH1627072A patent/CH545299A/en not_active IP Right Cessation
- 1972-11-08 BR BR7834/72A patent/BR7207834D0/en unknown
- 1972-11-09 AR AR245050A patent/AR192677A1/en active
- 1972-11-09 JP JP47111724A patent/JPS51120B2/ja not_active Expired
- 1972-11-10 DE DE2255203A patent/DE2255203A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7214368A (en) | 1973-05-14 |
| NL153548B (en) | 1977-06-15 |
| OA04191A (en) | 1979-12-31 |
| IE36822B1 (en) | 1977-03-02 |
| NO137095B (en) | 1977-09-19 |
| AR192677A1 (en) | 1973-02-28 |
| BR7207834D0 (en) | 1973-09-20 |
| DK133381C (en) | 1976-10-04 |
| JPS4947399A (en) | 1974-05-08 |
| IE36822L (en) | 1973-05-10 |
| DE2255203A1 (en) | 1973-05-17 |
| GB1355899A (en) | 1974-06-05 |
| BE789252A (en) | 1973-03-26 |
| DK133381B (en) | 1976-05-10 |
| SE383350B (en) | 1976-03-08 |
| IL40762A0 (en) | 1973-01-30 |
| CH545299A (en) | 1973-12-15 |
| CA972746A (en) | 1975-08-12 |
| ZA727831B (en) | 1973-07-25 |
| JPS51120B2 (en) | 1976-01-05 |
| FR2159720A5 (en) | 1973-06-22 |
| AU4858272A (en) | 1974-05-09 |
| IL40762A (en) | 1975-07-28 |
| AU464986B2 (en) | 1975-09-11 |
| NO137095C (en) | 1977-12-28 |
| AT330374B (en) | 1976-06-25 |
| LU66165A1 (en) | 1974-04-02 |
| ATA945672A (en) | 1975-09-15 |
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