ES408008A2 - Procedure for the preparation of 2- (furilmetil) -6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 2- (furilmetil) -6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES408008A2 ES408008A2 ES408008A ES408008A ES408008A2 ES 408008 A2 ES408008 A2 ES 408008A2 ES 408008 A ES408008 A ES 408008A ES 408008 A ES408008 A ES 408008A ES 408008 A2 ES408008 A2 ES 408008A2
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen atom
- signifies
- methyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 4
- -1 1,2-diphenylethyl group Chemical group 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004998 naphthylethyl group Chemical group C1(=CC=CC2=CC=CC=C12)CC* 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Improvements made to the subject of main patent No. 399,536, applied for on February 7, 1972, by: "Procedure for the preparation of 2- (furylmethyl) -6,7-benzomorphanes" of the general formula **(See formula)** where R signifies a hydrogen atom or a methyl or acetyl group, R1 signifies a hydrogen atom, a methyl, ethyl, n-propyl, isopropyl or butyl group; R2 signifies a hydrogen atom, a methyl or ethyl group; and R3 signifies a hydrogen atom or a methyl or ethyl group; and its acid addition salts, characterized in that a quaternary ammonium salt of the formula is reacted **(See formula)** wherein R1, R2, R4 and Z are as defined above and R5 represents an easy group to remove by Hofmann removal, preferably a phenethyl, naphthylethyl or 1,2-diphenylethyl group and X means a halide anion or sulfonate, by treatment with alkalis, to form a compound of formula IV **(See formula)** and -if compounds of formula IV are obtained, in which Z does not have the meaning of R3- the substituent Z is transformed by chemical reaction into a hydrogen atom or a methyl or ethyl group; and if desired - for the preparation of a compound of the formula I, in which R signifies a hydrogen atom - a compound of the formula is dealkoxylated or deacylated **(See formula)** wherein R1, R2 and R3 have the meanings mentioned above and R4 signifies an alcohol, aralcohyl or acyl group; and if desired for the preparation of a compound of formula I, in which R means a methyl or acetyl group, a compound of formula IVa is methylated or acetylated, in which R1 and R2 have the aforementioned meanings and R4 designates a hydrogen atom; and eventually the compounds of the general formula I are transformed into their physiologically harmless acid addition salts. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES408008A ES408008A2 (en) | 1972-10-26 | 1972-10-26 | Procedure for the preparation of 2- (furilmetil) -6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES408008A ES408008A2 (en) | 1972-10-26 | 1972-10-26 | Procedure for the preparation of 2- (furilmetil) -6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES408008A2 true ES408008A2 (en) | 1975-11-16 |
Family
ID=8462494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES408008A Expired ES408008A2 (en) | 1972-10-26 | 1972-10-26 | Procedure for the preparation of 2- (furilmetil) -6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES408008A2 (en) |
-
1972
- 1972-10-26 ES ES408008A patent/ES408008A2/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19890227 |