ES405492A1 - Procedimiento para la preparacion de esteres o sales de a- cidos biliares. - Google Patents

Procedimiento para la preparacion de esteres o sales de a- cidos biliares.

Info

Publication number: ES405492A1
Authority: ES; Spain
Prior art keywords: acid; bile; coo; alk; choleretically
Prior art date: 1971-08-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES405492A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Medichemie AG

Original Assignee

Medichemie AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-08-04

Filing date

1972-08-03

Publication date

1975-07-16

1971-08-04 Priority claimed from CH1148471A external-priority patent/CH557808A/de

1971-09-28 Priority claimed from CH1408571A external-priority patent/CH551998A/de

1972-01-24 Priority claimed from CH101272A external-priority patent/CH565129A5/de

1972-08-03 Application filed by Medichemie AG filed Critical Medichemie AG

1975-07-16 Publication of ES405492A1 publication Critical patent/ES405492A1/es

Status Expired legal-status Critical Current

Links

239000003613 bile acid Substances 0.000 title abstract 5
150000002148 esters Chemical class 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 3
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 abstract 2
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 2
BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 abstract 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 abstract 1
OHXPGWPVLFPUSM-KLRNGDHRSA-N 3,7,12-trioxo-5beta-cholanic acid Chemical compound C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC(O)=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C OHXPGWPVLFPUSM-KLRNGDHRSA-N 0.000 abstract 1
KSEBMYQBYZTDHS-UHFFFAOYSA-N 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
239000004380 Cholic acid Substances 0.000 abstract 1
WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 abstract 1
SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 abstract 1
XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229960001091 chenodeoxycholic acid Drugs 0.000 abstract 1
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 abstract 1
BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 1
229960002471 cholic acid Drugs 0.000 abstract 1
235000019416 cholic acid Nutrition 0.000 abstract 1
229930016911 cinnamic acid Natural products 0.000 abstract 1
235000013985 cinnamic acid Nutrition 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
229960002997 dehydrocholic acid Drugs 0.000 abstract 1
KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 abstract 1
229960003964 deoxycholic acid Drugs 0.000 abstract 1
-1 ethylene, propylene Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 abstract 1
SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229960005010 orotic acid Drugs 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

ES405492A 1971-08-04 1972-08-03 Procedimiento para la preparacion de esteres o sales de a- cidos biliares. Expired ES405492A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH1148471A CH557808A (de)	1971-08-04	1971-08-04	Verfahren zur herstellung von salzen von gallensaeuredialkylamino-alkylestern mit substituierten zimtsaeuren.
CH1408571A CH551998A (de)	1971-09-28	1971-09-28	Verfahren zur herstellung eines salzes von gallensaeuredialkylaminoalkylestern.
CH101272A CH565129A5 (en)	1972-01-24	1972-01-24	Esters and salts of cholic acid derivs - having choleretic activity

Publications (1)

Publication Number	Publication Date
ES405492A1 true ES405492A1 (es)	1975-07-16

Family

ID=27172602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES405492A Expired ES405492A1 (es)	1971-08-04	1972-08-03	Procedimiento para la preparacion de esteres o sales de a- cidos biliares.

Country Status (11)

Country	Link
US (1)	US3846411A (es)
BE (1)	BE786477A (es)
CA (1)	CA969173A (es)
DE (1)	DE2238304C3 (es)
DK (1)	DK135721B (es)
ES (1)	ES405492A1 (es)
FR (1)	FR2148002B1 (es)
GB (1)	GB1388427A (es)
IL (1)	IL39999A0 (es)
NL (1)	NL7210586A (es)
SE (1)	SE378811B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3910888A (en) *	1971-08-04	1975-10-07	Medichemie A G	Choleretically active esters and salts of bile acids
US3931256A (en) *	1972-09-21	1976-01-06	Intellectual Property Development Corporation	Chemical process for production of bile acids
US5079240A (en) *	1990-03-15	1992-01-07	The Regents Of The University Of California	Synthetic conjugated bile acid and method of use thereof
WO2008149563A1 (ja) *	2007-06-04	2008-12-11	Nihon University	作用選択的ビタミンｄ受容体作用剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2562350A (en) *	1945-10-12	1951-07-31	Searle & Co	Basic esters of bile acids
US2763645A (en) *	1955-01-28	1956-09-18	Pfizer & Co C	Amino alcohol esters of etiocholene 17 alpha hydroxy 3 one 17 beta carboxylic acid
US3534070A (en) *	1968-03-12	1970-10-13	Dainippon Pharmaceutical Co	3,7,12-triketocholanyl-alpha-amino acids

1972
- 1972-07-17 SE SE7209401A patent/SE378811B/xx unknown
- 1972-07-17 US US00272156A patent/US3846411A/en not_active Expired - Lifetime
- 1972-07-18 GB GB3358672A patent/GB1388427A/en not_active Expired
- 1972-07-19 BE BE786477A patent/BE786477A/xx unknown
- 1972-07-20 FR FR7226261A patent/FR2148002B1/fr not_active Expired
- 1972-07-20 DK DK359972AA patent/DK135721B/da unknown
- 1972-07-25 CA CA147,854A patent/CA969173A/en not_active Expired
- 1972-07-26 IL IL39999A patent/IL39999A0/xx unknown
- 1972-08-02 NL NL7210586A patent/NL7210586A/xx not_active Application Discontinuation
- 1972-08-03 DE DE2238304A patent/DE2238304C3/de not_active Expired
- 1972-08-03 ES ES405492A patent/ES405492A1/es not_active Expired

Also Published As

Publication number	Publication date
DK135721C (es)	1977-11-14
FR2148002A1 (es)	1973-03-11
FR2148002B1 (es)	1975-10-31
CA969173A (en)	1975-06-10
GB1388427A (en)	1975-03-26
BE786477A (fr)	1972-11-16
NL7210586A (es)	1973-02-06
IL39999A0 (en)	1972-09-28
SE378811B (es)	1975-09-15
DE2238304B2 (de)	1980-07-03
DE2238304C3 (de)	1981-06-19
US3846411A (en)	1974-11-05
DE2238304A1 (de)	1973-02-15
DK135721B (da)	1977-06-13

Publication	Publication Date	Title
GB1148570A (en)	1969-04-16	N,n'-diglycidyl compounds and process for their manufacture and use
GB1346428A (en)	1974-02-13	Emulsifier compositions
GB1434919A (en)	1976-05-12	3alpha-hydroxy androstanes
ES405492A1 (es)	1975-07-16	Procedimiento para la preparacion de esteres o sales de a- cidos biliares.
GB1386939A (en)	1975-03-12	Alkyl esters of alpha-aspartyl alpha-alkyl aliphatic amino acid dipeptides
ES411112A1 (es)	1976-01-01	Procedimiento de preparacion de nuevos derivados del 1'1- difenil-etileno.
ES441783A1 (es)	1977-04-01	Procedimiento para la preparacion de 1-alfa-hidroxiesteroi- des.
GB1118976A (en)	1968-07-03	New bisnorcholane derivatives and process for their manufacture
GB1387911A (en)	1975-03-19	Pregnane acid derivatives
ES454283A1 (es)	1977-12-16	Procedimiento para la produccion de un peptido.
ES472263A1 (es)	1979-02-16	Procedimiento para preparar derivados de urea
GB1074492A (en)	1967-07-05	Novel processes for preparing steroid compounds, the comopounds when thus prepared, novel steroid compounds thereby prepared, and pharmaceutical compositions containing the novel compounds
GB1187659A (en)	1970-04-15	Testosterone Derivatives
GB1060344A (en)	1967-03-01	New derivatives of glycyrrhetinic and oleanolic acids
ES444957A1 (es)	1977-04-16	Procedimiento para preparar derivados de acido glicirretini-co.
ES429818A1 (es)	1976-09-01	Procedimiento para preparar derivados del acido tricloroa- cetamido-7 desacetoxi-3 cefalosporanico.
ES480329A1 (es)	1980-02-01	Procedimiento para la preparacion de derivados de acidos benzoilfenoxialcanoicos.
ES343838A1 (es)	1968-10-01	Procedimiento para la obtencion de amidas de acido.
GB1133675A (en)	1968-11-13	Improvements in or relating to alkanoamides or benzamides and the manufacture thereof
GB1355663A (en)	1974-06-05	19-nortestosterone 17- -p-substituted phenoxy-acetates
GB1357564A (en)	1974-06-26	Glycoproteins
GB993255A (en)	1965-05-26	Process for the production of dibenzoazepine derivatives
ES436058A1 (es)	1977-01-01	Procedimiento para preparar esteres de acidos pirimidin (2) il-tionofosforicos.
GB1029440A (en)	1966-05-11	New methyl-androstanes
ES481486A1 (es)	1980-07-01	Procedimientos para preparar derivados de acidos 1-pirrol- carboxilixos