ES375097A1 - Improvements in or relating to imidazoisoindole derivatives - Google Patents
Improvements in or relating to imidazoisoindole derivativesInfo
- Publication number
- ES375097A1 ES375097A1 ES375097A ES375097A ES375097A1 ES 375097 A1 ES375097 A1 ES 375097A1 ES 375097 A ES375097 A ES 375097A ES 375097 A ES375097 A ES 375097A ES 375097 A1 ES375097 A1 ES 375097A1
- Authority
- ES
- Spain
- Prior art keywords
- imidazo
- chlorophenyl
- dihydro
- general formula
- isoindoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NVZLBPXTJTXPDC-UHFFFAOYSA-N pyrrolo[3,4-e]benzimidazole Chemical class C1=CC2=NC=NC2=C2C=NC=C21 NVZLBPXTJTXPDC-UHFFFAOYSA-N 0.000 title 1
- HOWDMACAMGSJKS-UHFFFAOYSA-N 2-(3-chlorophenyl)-5-hydroperoxy-3,5-dihydro-2H-imidazo[2,1-a]isoindole Chemical class ClC=1C=CC=C(C1)C1N=C2N(C(C3=CC=CC=C23)OO)C1 HOWDMACAMGSJKS-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- GBLJAZNBEMGXEH-UHFFFAOYSA-N 2-(3-chlorophenyl)-3,5-dihydro-2H-imidazo[2,1-a]isoindole Chemical compound ClC=1C=CC=C(C1)C1N=C2N(CC3=CC=CC=C23)C1 GBLJAZNBEMGXEH-UHFFFAOYSA-N 0.000 abstract 1
- KEXWNJBTRCVBTI-UHFFFAOYSA-N ClC=1C=CC=C(C=1)C1N=C2N(C(C3=CC=CC=C23)O)C1 Chemical class ClC=1C=CC=C(C=1)C1N=C2N(C(C3=CC=CC=C23)O)C1 KEXWNJBTRCVBTI-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002830 appetite depressant Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04C—STRUCTURAL ELEMENTS; BUILDING MATERIALS
- E04C2/00—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels
- E04C2/02—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials
- E04C2/26—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials composed of materials covered by two or more of groups E04C2/04, E04C2/08, E04C2/10 or of materials covered by one of these groups with a material not specified in one of the groups
- E04C2/284—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials composed of materials covered by two or more of groups E04C2/04, E04C2/08, E04C2/10 or of materials covered by one of these groups with a material not specified in one of the groups at least one of the materials being insulating
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Architecture (AREA)
- Engineering & Computer Science (AREA)
- Civil Engineering (AREA)
- Structural Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel 5 - chlorophenyl - 5 - hydroperoxy- 2,3 - dihydro - 5H - imidazo - [2,1-a] - isoindoles of the general formula wherein R 1 is a hydrogen or chlorine atom, are prepared by oxidation of a 5-chlorophenyl-2,3- dihydro - 5H - imidazo - [2,1-a] - isoindole of the general formula with oxygen at a temperature of from 15 to 35 C. in an ether or C 1-4 alkanol solvent The 5 - chlorophenyl - 5 - hydroperoxy - 2,3- dihydro - 5H - imidazo - [2,1-a] - isoindoles of the first general formula above may be agitated in a solvent at a temperature of from 15 to 35 C. to produce 5-chlorophenyl-5-hydroxy- 2,3 - dihydro - 5H - imidazo - [2,1-a] - isoindoles of the general formula Pharmaceutical compositions having appetite depressant activity comprise, as active ingredient, a 5-chlorophenyl-5-hydroperoxy-2,3-dihydro - 5H - imidazo - [2,1-a] - isoindole of the first general formula above, together with a pharmaceutically acceptable diluent or carrier, and may be administered orally or parenterally.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69122967A | 1967-12-18 | 1967-12-18 | |
| US74677568A | 1968-07-23 | 1968-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES375097A1 true ES375097A1 (en) | 1972-08-16 |
Family
ID=27104753
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES361493A Expired ES361493A1 (en) | 1967-12-18 | 1968-12-16 | PROCEDURE FOR THE PRODUCTION OF ISOINDOL DERIVATIVES. |
| ES375096A Expired ES375096A1 (en) | 1967-12-18 | 1969-12-31 | PROCEDURE FOR THE PRODUCTION OF DERIVATIVES OF ISOINDOL. |
| ES375097A Expired ES375097A1 (en) | 1967-12-18 | 1969-12-31 | Improvements in or relating to imidazoisoindole derivatives |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES361493A Expired ES361493A1 (en) | 1967-12-18 | 1968-12-16 | PROCEDURE FOR THE PRODUCTION OF ISOINDOL DERIVATIVES. |
| ES375096A Expired ES375096A1 (en) | 1967-12-18 | 1969-12-31 | PROCEDURE FOR THE PRODUCTION OF DERIVATIVES OF ISOINDOL. |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE725569A (en) |
| CA (1) | CA945993A (en) |
| CH (1) | CH503044A (en) |
| DE (1) | DE1814540A1 (en) |
| ES (3) | ES361493A1 (en) |
| FR (2) | FR1596124A (en) |
| GB (1) | GB1249488A (en) |
| SE (1) | SE342632B (en) |
-
1968
- 1968-12-10 CH CH1838868A patent/CH503044A/en not_active IP Right Cessation
- 1968-12-12 DE DE19681814540 patent/DE1814540A1/en active Pending
- 1968-12-12 GB GB59064/68A patent/GB1249488A/en not_active Expired
- 1968-12-13 SE SE17156/68A patent/SE342632B/xx unknown
- 1968-12-16 FR FR1596124D patent/FR1596124A/fr not_active Expired
- 1968-12-16 BE BE725569D patent/BE725569A/xx unknown
- 1968-12-16 ES ES361493A patent/ES361493A1/en not_active Expired
- 1968-12-17 CA CA037,996A patent/CA945993A/en not_active Expired
-
1969
- 1969-03-12 FR FR183277A patent/FR8258M/fr not_active Expired
- 1969-12-31 ES ES375096A patent/ES375096A1/en not_active Expired
- 1969-12-31 ES ES375097A patent/ES375097A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1814540A1 (en) | 1969-07-03 |
| CH503044A (en) | 1971-02-15 |
| ES361493A1 (en) | 1970-12-01 |
| FR8258M (en) | 1970-10-19 |
| CA945993A (en) | 1974-04-23 |
| FR1596124A (en) | 1970-06-15 |
| SE342632B (en) | 1972-02-14 |
| GB1249488A (en) | 1971-10-13 |
| ES375096A1 (en) | 1972-08-16 |
| BE725569A (en) | 1969-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1246006A (en) | Pyrazine derivatives and their conversion to imidazopyrazines | |
| ES8505173A1 (en) | Bicyclic carboxylic acids and their alkyl and aralkyl esters. | |
| GB1054104A (en) | ||
| ES375097A1 (en) | Improvements in or relating to imidazoisoindole derivatives | |
| ES356776A2 (en) | Isoindolino-sulphonylurea compounds | |
| ES339432A1 (en) | Novel halo-substituted tetrahydro-quinazolines | |
| GB1152627A (en) | Improvements in or relating to Oxazole Derivatives | |
| ES366465A1 (en) | PROCEDURE FOR THE PREPARATION OF SULFONYLUREA DERIVATIVES. | |
| GB1416705A (en) | Keto-esters | |
| GB1394184A (en) | 4,5-dihydropyridazine-3 2h- ones | |
| GB1298057A (en) | Bis(aminoalkylsulphamoyl)anthraquinones | |
| GB1021070A (en) | A new triazolone and a process for its preparation | |
| GB1351577A (en) | Bis-basic esters of fluorene and fluorenone | |
| GB1034613A (en) | Improvements in or relating to pyrazolone carboxylic esters | |
| GB1457950A (en) | Antibacterial compositions | |
| GB1364318A (en) | Laurotetanine derivatives | |
| GB1346456A (en) | Organic acid 2,6-disubstituted phenyl hydrazides | |
| GB1164412A (en) | Derivatives of 2alpha,3alpha-Epithiosteroids and process for the preparation thereof | |
| GB1173577A (en) | Improvements in or relating to New Indole Derivatives, Process for Preparing same and Therapeutic Compositions Containing them | |
| ES336293A1 (en) | PROCEDURE TO PREPARE BENZOCYCLOHEPTA-THIOPHENE ETHERS. | |
| ES381115A1 (en) | 1 1'-methylenebis(4-(3-chlorophenyl) piperazine) | |
| GB1202110A (en) | Novel quinoline derivatives and their preparation | |
| GB1223548A (en) | Fluorene-derived sulphones | |
| ES268434A1 (en) | Substituted benzamides having tranquillizing activity | |
| GB1213998A (en) | N,n'-alkylene-bis-dibenzobicyclooctano-pyrrolidine compounds and the production thereof |