ES353407A1 - Procedure for the manufacture of halogenated compounds of the pregnan series. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the manufacture of halogenated compounds of the pregnan series. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES353407A1 ES353407A1 ES353407A ES353407A ES353407A1 ES 353407 A1 ES353407 A1 ES 353407A1 ES 353407 A ES353407 A ES 353407A ES 353407 A ES353407 A ES 353407A ES 353407 A1 ES353407 A1 ES 353407A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- general formula
- translation
- manufacture
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000003128 pregnanes Chemical class 0.000 abstract 1
- 230000002269 spontaneous effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for the manufacture of halogenated compounds of the pregnane series of general formula i ** (see formula) ** Wherein x means a halogen atom, especially chlorine, fluorine or bromine and r means an alkyl radical having 1 to 5 carbon atoms, from corresponding derivatives of 17alpha-acyloxy-3-alkoxy-6-halogen-16-methylene -pregna-3,5-diene-20-one of the general formula ii ** (see formula) ** Wherein x and r mean the same as in formula i and r'means an alkyl radical having 1 to 6 carbon atoms, characterized in that it is transformed to the starting compound by the addition of 1 mol of halogen in elemental form or 1 mol of a hypohalogenous acid, with simultaneous spontaneous hydrolysis of the alkoxy group in position 3, in the corresponding derivative 6alpha, 6beta-dihalogeno-17alpha-acyloxy-16-methyleneprogesterone of the general formula iii ** (see formula) ** Wherein x and r mean the same as in formula i, and y means a halogen atom, especially chlorine or bromine, which is identical to or may be different from the halogen atom x, after which it is separated from it the hydrogen halide hy is derived, with formation of the compound of the general formula i. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES353407A ES353407A1 (en) | 1968-05-02 | 1968-05-02 | Procedure for the manufacture of halogenated compounds of the pregnan series. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES353407A ES353407A1 (en) | 1968-05-02 | 1968-05-02 | Procedure for the manufacture of halogenated compounds of the pregnan series. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES353407A1 true ES353407A1 (en) | 1969-10-01 |
Family
ID=8448868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES353407A Expired ES353407A1 (en) | 1968-05-02 | 1968-05-02 | Procedure for the manufacture of halogenated compounds of the pregnan series. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES353407A1 (en) |
-
1968
- 1968-05-02 ES ES353407A patent/ES353407A1/en not_active Expired
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