ES271160A2 - Procedure for the preparation of amino-norcanfanderivados N-substituidos (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Improvements in the object of the main patent No. 259,882 by the process for the preparation of N-substituted amino-norcanfanderivates, of analeptic activity, characterized in that a compound of the general formula ** (See formula) ** in which R1 denotes phenyl or phenyl substituted once or several times with alkyl having 1 to 3 carbon atoms, OH, alkoxy with 1 to 3 carbon atoms or halogen; naphthyl, phenylalkyl with 7 to 8 carbon atoms, cyclohexyl or a 5- or 6-membered heterocyclic radical containing nitrogen or sulfur and R2 means H or alkyl with 1 to 2 carbon atoms, is alkylated once or twice in nitrogen, with formation of a compound of the general formula ** (See formula) ** in which R1 and R2 have the meaning indicated above, R3 is H, alkyl having 1 to 3 carbon atoms or R4 and R4 means alkenyl or alkynyl with 2 to 5 carbon atoms each, or alkyl with 2 to 5 carbon atoms, cycloalkyl with 5 to 6 carbon atoms or aralkyl with 7 to 8 carbon atoms, which in each case are substituted or several times by OH, halogen, alkoxy or alkylthio having 1 to 3 carbon atoms each or by NH2, in which case one of the hydrogen atoms, or both, of the NH2 group can be substituted by alkyl radicals with 1 to 3 carbon atoms or the nitrogen atom can be a component of a 5 or 6 member ring, or R3 and R4 together with the nitrogen atom form a 5- or 6-membered ring which is substituted by = 0, OH, halogen and/or one or more alkyl groups with 1 to 3 carbon atoms, and optionally the substituted amines of the formula II thus obtained are converted into quaternary ammonium salts or, by treatment with an acid, into the corresponding physiologically harmless acid addition salts. (Machine-translation by Google Translate, not legally binding)