ES406134A1 - Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES406134A1 ES406134A1 ES406134A ES406134A ES406134A1 ES 406134 A1 ES406134 A1 ES 406134A1 ES 406134 A ES406134 A ES 406134A ES 406134 A ES406134 A ES 406134A ES 406134 A1 ES406134 A1 ES 406134A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- radical
- alcohol
- signifies hydrogen
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- IRXWBCKPECPALY-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinoline-1-thione Chemical class C1=CC=C2C(=S)NCCC2=C1 IRXWBCKPECPALY-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure for the preparation of 3,4-dihydro-2H-isoquinoline-1-thiones of the general formula **(See formula)** in which R1 and R2 each signify the same or different alcohol radicals, each with 1 to 6 carbon atoms or R1 signifies a phenylalkyl radical with 7 or 8 carbon atoms or a phenyl radical and at the same time R2 signifies hydrogen, a alcoholic or alcoholic radical with 1 to 6 carbon atoms, a carbon atom being able to be replaced by an oxygen or sulfur atom or it means a phenyl radical, being able to form R1 and R2 also, together with the carbon atom in position 4, a ring 5- or 6-membered saturated carbocyclic, R3 signifies hydrogen or an alkoxy group with 1 to 4 carbon atoms, and R4 signifies hydrogen or together with R3 the 6,7-oxymethylene group, and R5 signifies hydrogen or an alcohol radical with 1 to 4 6 carbon atoms, preferably with 1-4 carbon atoms, characterized in that a) it is subjected to cyclization by treatment with acid catalysts to compounds of the general formulas **(See formula)** wherein R1 to R5 have the above meanings and Y means an optionally substituted amino group, an O-alcohol or S-alcohol radical or an S-phenyl radical; or b) in compounds of the general formula III **(See formula)** the oxygen atom is replaced by sulfur in a manner known per se. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2143745A DE2143745A1 (en) | 1971-09-01 | 1971-09-01 | 3,4-DIHYDRO-2H-ISOCHINOLIN-1-THIONE AND THE METHOD FOR MANUFACTURING IT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES406134A1 true ES406134A1 (en) | 1975-08-01 |
Family
ID=5818354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES406134A Expired ES406134A1 (en) | 1971-09-01 | 1972-08-26 | Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding) |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS4834885A (en) |
| AU (1) | AU4610472A (en) |
| BE (1) | BE788321A (en) |
| CA (1) | CA972755A (en) |
| DD (1) | DD102148A5 (en) |
| DE (1) | DE2143745A1 (en) |
| ES (1) | ES406134A1 (en) |
| FR (1) | FR2151044A1 (en) |
| IL (1) | IL40250A0 (en) |
| NL (1) | NL7211627A (en) |
| ZA (1) | ZA725997B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89997A0 (en) * | 1988-04-25 | 1989-12-15 | Lilly Co Eli | Propanamine derivatives |
| US5177075A (en) * | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| CA1334969C (en) * | 1988-08-19 | 1995-03-28 | Mark James Suto | Substituted dihydroisoquinoline and phthalazine derivatives as potentiators of the lethal effects of radiation and certain chemotherapeutic agents, selected compounds, analogs andprocess |
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| DE60218458T2 (en) * | 2001-05-08 | 2007-11-15 | Kudos Pharmaceuticals Ltd. | ISOCHINOLINONE DERIVATIVES AS PARP INHIBITORS |
| EP1501822B1 (en) | 2002-04-30 | 2010-12-15 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| RU2010108008A (en) | 2007-09-14 | 2011-10-20 | Астразенека Аб (Se) | Phthalazinone derivatives |
| RU2487868C2 (en) | 2007-10-17 | 2013-07-20 | Кудос Фармасеутикалс Лимитед | 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluor-benzyl]-2h-phthalazin-1-one |
| UY31603A1 (en) | 2008-01-23 | 2009-08-31 | DERIVATIVES OF FTALAZINONA | |
| RS55157B2 (en) | 2008-10-07 | 2023-10-31 | Kudos Pharm Ltd | Pharmaceutical formulation 514 |
-
1971
- 1971-09-01 DE DE2143745A patent/DE2143745A1/en active Pending
-
1972
- 1972-08-16 DD DD165084A patent/DD102148A5/xx unknown
- 1972-08-25 NL NL7211627A patent/NL7211627A/xx unknown
- 1972-08-25 CA CA150,238A patent/CA972755A/en not_active Expired
- 1972-08-26 ES ES406134A patent/ES406134A1/en not_active Expired
- 1972-08-29 IL IL40250A patent/IL40250A0/en unknown
- 1972-08-30 AU AU46104/72A patent/AU4610472A/en not_active Expired
- 1972-08-31 ZA ZA725997A patent/ZA725997B/en unknown
- 1972-08-31 FR FR7230951A patent/FR2151044A1/en not_active Withdrawn
- 1972-09-01 JP JP47087839A patent/JPS4834885A/ja active Pending
- 1972-09-01 BE BE788321D patent/BE788321A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2143745A1 (en) | 1973-03-08 |
| IL40250A0 (en) | 1972-10-29 |
| BE788321A (en) | 1973-03-01 |
| ZA725997B (en) | 1973-07-25 |
| CA972755A (en) | 1975-08-12 |
| DD102148A5 (en) | 1973-12-05 |
| AU4610472A (en) | 1974-03-07 |
| JPS4834885A (en) | 1973-05-22 |
| NL7211627A (en) | 1973-03-05 |
| FR2151044A1 (en) | 1973-04-13 |
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