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ES2122472T3 - Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2122472T3
ES2122472T3 ES95400987T ES95400987T ES2122472T3 ES 2122472 T3 ES2122472 T3 ES 2122472T3 ES 95400987 T ES95400987 T ES 95400987T ES 95400987 T ES95400987 T ES 95400987T ES 2122472 T3 ES2122472 T3 ES 2122472T3
Authority
ES
Spain
Prior art keywords
erythromycin
medicines
derivatives
application
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95400987T
Other languages
English (en)
Inventor
Constantin Agouridas
Jean-Francois Chantot
Alexis Denis
D Ambrieres Solange Gouin
Martret Odile Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel
Application granted granted Critical
Publication of ES2122472T3 publication Critical patent/ES2122472T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I) EN LAS QUE - R REPRESENTA UN RADICAL -(CH{SUB,2}){SUB,N}AR, - N REPRESENTA EL NUMERO 3,4 O 5 - AR REPRESENTA UN RADICAL HETEROCICLICO, EVENTUALMENTE SUSTITUIDO, - Z REPRESENTA UN ATOMO DE HIDROGENO O EL RESTO DE UN ACIDO. LOS COMPUESTOS DE FORMULA (I) PRESENTAN INTERESANTES PROPIEDADES ANTIBIOTICAS.
ES95400987T 1994-05-03 1995-05-02 Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2122472T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number Publication Date
ES2122472T3 true ES2122472T3 (es) 1998-12-16

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95400987T Expired - Lifetime ES2122472T3 (es) 1994-05-03 1995-05-02 Derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Country Status (42)

Country Link
US (2) US5635485A (es)
EP (1) EP0680967B1 (es)
JP (4) JP2992540B2 (es)
KR (1) KR100312267B1 (es)
CN (2) CN1052984C (es)
AP (1) AP558A (es)
AT (1) ATE172203T1 (es)
AU (1) AU684027B2 (es)
BG (1) BG63087B1 (es)
BR (1) BR9507700A (es)
CA (1) CA2189271C (es)
CZ (1) CZ293455B6 (es)
DE (2) DE69505296T2 (es)
DK (1) DK0680967T3 (es)
DZ (1) DZ1878A1 (es)
EE (1) EE03263B1 (es)
ES (1) ES2122472T3 (es)
FI (1) FI111263B (es)
FR (1) FR2719587B1 (es)
GE (1) GEP19991538B (es)
HU (2) HU227493B1 (es)
IL (1) IL113245A (es)
LU (1) LU90872I2 (es)
LV (1) LV11739B (es)
MA (1) MA23534A1 (es)
MD (1) MD1233C2 (es)
NL (1) NL300077I1 (es)
NO (2) NO308853B1 (es)
NZ (1) NZ285416A (es)
OA (1) OA10319A (es)
PL (1) PL182034B1 (es)
RO (1) RO113350B1 (es)
RU (1) RU2144036C1 (es)
SI (1) SI0680967T1 (es)
SK (1) SK281707B6 (es)
TJ (1) TJ313B (es)
TN (1) TNSN95049A1 (es)
TW (1) TW341573B (es)
UA (1) UA51618C2 (es)
WO (1) WO1995029929A1 (es)
YU (1) YU49235B (es)
ZA (1) ZA953501B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2306590A1 (es) * 2006-12-15 2008-11-01 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001539A1 (en) * 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ATE299508T1 (de) * 1996-09-04 2005-07-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
ES2243066T3 (es) 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
ES2273964T3 (es) 1998-12-10 2007-05-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
ATE256694T1 (de) * 1999-01-27 2004-01-15 Pfizer Prod Inc Ketolid-antibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
MXPA01010521A (es) * 1999-04-16 2003-08-19 Johnson & Johnson Antibacteriales de cetolidos.
EP1171446B1 (en) 1999-04-16 2006-09-20 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
WO2002016380A1 (en) * 2000-08-22 2002-02-28 Basilea Pharmaceutica Ag New macrolides with antibacterial activity
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
AU2002316550A1 (en) * 2001-07-03 2003-01-21 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
WO2004005313A2 (en) 2002-07-08 2004-01-15 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
PL374731A1 (en) 2002-07-08 2005-10-31 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
DE10305391A1 (de) * 2003-02-11 2004-08-19 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von Pyridin-substituierten Aminoketal-Derivaten
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
CA2801100A1 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
EP1670808A1 (en) * 2003-09-12 2006-06-21 Chiron Corporation Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2005105821A2 (en) * 2004-04-28 2005-11-10 Alembic Limited Process for the preparation of telithromycin
RU2397987C2 (ru) * 2004-07-28 2010-08-27 Рэнбакси Лабораториз Лимитед Кетолидные производные в качестве антибактериальных агентов
US20090170790A1 (en) * 2004-10-25 2009-07-02 Biswajit Das Ketolide derivatives as antibacterial agents
CN101120011A (zh) 2004-12-21 2008-02-06 辉瑞产品公司 大环内酯
EP2549491B1 (en) * 2005-02-08 2017-07-26 Murata Manufacturing Co., Ltd. Surface mountable negative coefficient characteristic ceramic thermistor based on Mn, Co and Ti
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
WO2007059307A2 (en) * 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of telithromycin
US20090130225A1 (en) * 2005-11-23 2009-05-21 Anjan Chakrabarti Macrolides derivatives as antibacterial agents
EP1954294A2 (en) * 2005-11-23 2008-08-13 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
EP1957508A2 (en) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
EP1985620A4 (en) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd 10a-azalide compound
CN101541331A (zh) 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. １０ａ、１２位架橋型１０ａ－アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
US7926879B2 (en) 2007-09-20 2011-04-19 Herman Miller, Inc. Load support structure
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009053259A1 (en) * 2007-10-25 2009-04-30 Sandoz Ag Process for the production of telithromycin
US8299035B2 (en) * 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
RU2011153353A (ru) 2009-05-27 2013-07-10 Вокхардт Рисерч Сентер Кетолидные соединения, обладающие противомикробной активностью
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
CN108570083A (zh) 2010-03-22 2018-09-25 森普拉制药公司 大环内脂的结晶形式及其用途
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
CA2820451C (en) 2010-12-09 2017-12-12 Wockhardt Limited Ketolide compounds
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
DE3750023T2 (de) * 1986-10-29 1994-09-29 Pfizer, Inc., New York, N.Y. Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5403923A (en) * 1990-11-28 1995-04-04 Taisho Pharmaceutical Co., Ltd. 6-0-methylerythromycin A derivatives
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2306590A1 (es) * 2006-12-15 2008-11-01 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.

Also Published As

Publication number Publication date
BG63087B1 (bg) 2001-03-30
MD1233C2 (ro) 2000-10-31
DZ1878A1 (fr) 2002-02-17
AP558A (en) 1996-11-07
JP2007269810A (ja) 2007-10-18
TNSN95049A1 (fr) 1996-02-06
DE69505296T2 (de) 1999-04-22
CZ321496A3 (en) 1997-08-13
MA23534A1 (fr) 1995-12-31
NO964654D0 (no) 1996-11-04
KR100312267B1 (ko) 2002-06-22
JPH11152296A (ja) 1999-06-08
AU684027B2 (en) 1997-11-27
LU90872I2 (fr) 2002-03-12
RO113350B1 (ro) 1998-06-30
HU219599B (hu) 2001-05-28
PL317071A1 (en) 1997-03-03
NZ285416A (en) 1997-07-27
ZA953501B (en) 1996-05-02
NO964654L (no) 1996-11-04
TJ313B (en) 2001-08-06
CZ293455B6 (cs) 2004-05-12
DE69505296D1 (de) 1998-11-19
NO308853B1 (no) 2000-11-06
EP0680967A1 (fr) 1995-11-08
DK0680967T3 (da) 1999-06-23
ATE172203T1 (de) 1998-10-15
FR2719587B1 (fr) 1996-07-12
AP9500744A0 (en) 1995-07-31
HUT75698A (en) 1997-05-28
CN1151746A (zh) 1997-06-11
BR9507700A (pt) 1997-08-19
MD1233B1 (en) 1999-05-31
US5635485A (en) 1997-06-03
IL113245A (en) 1999-11-30
JPH0853489A (ja) 1996-02-27
FI964395L (fi) 1996-10-31
SI0680967T1 (en) 1999-02-28
JP4750755B2 (ja) 2011-08-17
DE10299001I1 (de) 2012-07-05
HU9904687D0 (en) 2000-03-28
WO1995029929A1 (fr) 1995-11-09
YU27095A (sh) 1998-05-15
FI964395A0 (fi) 1996-10-31
GEP19991538B (en) 1999-03-05
DE10299001I2 (de) 2012-07-05
JP3998828B2 (ja) 2007-10-31
JP4658902B2 (ja) 2011-03-23
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
US6100404A (en) 2000-08-08
SK281707B6 (sk) 2001-07-10
NO2001027I1 (no) 2002-01-28
PL182034B1 (pl) 2001-10-31
MX9605208A (es) 1997-09-30
CN1088709C (zh) 2002-08-07
NL300077I1 (nl) 2002-03-01
RU2144036C1 (ru) 2000-01-10
SK140296A3 (en) 1998-04-08
YU49235B (sh) 2004-12-31
OA10319A (fr) 1997-10-07
CA2189271A1 (fr) 1995-11-09
LV11739B (en) 1997-08-20
LV11739A (lv) 1997-04-20
EP0680967B1 (fr) 1998-10-14
CN1229082A (zh) 1999-09-22
UA51618C2 (uk) 2002-12-16
CN1052984C (zh) 2000-05-31
FI111263B (fi) 2003-06-30
CA2189271C (fr) 2005-12-27
IL113245A0 (en) 1995-07-31
TW341573B (en) 1998-10-01
AU2449995A (en) 1995-11-29
EE03263B1 (et) 2000-04-17
BG100951A (en) 1997-08-29
HK1010732A1 (en) 1999-06-25
JP2992540B2 (ja) 1999-12-20
JP2007045847A (ja) 2007-02-22
FR2719587A1 (fr) 1995-11-10

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