ES2119160T3 - Derivados de tiazolidina, su preparacion y los medicamentos que les contienen. - Google Patents
Derivados de tiazolidina, su preparacion y los medicamentos que les contienen.Info
- Publication number
- ES2119160T3 ES2119160T3 ES94904199T ES94904199T ES2119160T3 ES 2119160 T3 ES2119160 T3 ES 2119160T3 ES 94904199 T ES94904199 T ES 94904199T ES 94904199 T ES94904199 T ES 94904199T ES 2119160 T3 ES2119160 T3 ES 2119160T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- derivatives
- preparation
- thiazolidine
- medicines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title abstract 2
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical class C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title 1
- 102100025841 Cholecystokinin Human genes 0.000 abstract 3
- 101800001982 Cholecystokinin Proteins 0.000 abstract 3
- 229940107137 cholecystokinin Drugs 0.000 abstract 3
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 1
- 102100021022 Gastrin Human genes 0.000 abstract 1
- 102000052874 Gastrin receptors Human genes 0.000 abstract 1
- 108010052343 Gastrins Proteins 0.000 abstract 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
DERIVADOS DE FORMULA (I), SUS SALES, SU PREPARACION Y LOS MEDICAMENTOS QUE LOS CONTIENEN. LOS COMPUESTOS DE FORMULA (I) PRESENTAN PROPIEDADES FARMACOLOGICAS. ESTOS COMPUESTOS POSEEN UNA FUERTE AFINIDAD PARA LOS RECEPTORES DE LA COLECISTOQUININA (CCK) Y DE LA GASTRINA Y SON PUES UTILES EN EL TRATAMIENTO Y LA PREVENCION DE LOS TRASTORNOS UNIDOS A LA CCK QUE AFECTAN A LA GASTRINA REFERIDOS AL SISTEMA NERVIOSO Y AL APARATO GASTROINTSTINAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9300076A FR2700168B1 (fr) | 1993-01-07 | 1993-01-07 | Dérivés de thiazolidine, leur préparation et les médicaments les contenant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2119160T3 true ES2119160T3 (es) | 1998-10-01 |
Family
ID=9442864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94904199T Expired - Lifetime ES2119160T3 (es) | 1993-01-07 | 1994-01-03 | Derivados de tiazolidina, su preparacion y los medicamentos que les contienen. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5633270A (es) |
| EP (1) | EP0679161B1 (es) |
| JP (1) | JPH08507292A (es) |
| KR (1) | KR960700268A (es) |
| AT (1) | ATE167681T1 (es) |
| AU (1) | AU5835194A (es) |
| CA (1) | CA2152184A1 (es) |
| DE (1) | DE69411260T2 (es) |
| DK (1) | DK0679161T3 (es) |
| ES (1) | ES2119160T3 (es) |
| FR (1) | FR2700168B1 (es) |
| HU (1) | HUT73428A (es) |
| IL (1) | IL108289A0 (es) |
| NO (1) | NO952687L (es) |
| NZ (1) | NZ259530A (es) |
| WO (1) | WO1994015955A1 (es) |
| ZA (1) | ZA9479B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2721608B1 (fr) * | 1994-06-22 | 1996-07-19 | Rhone Poulenc Rorer Sa | Dérivés de thiazolidine, leur préparation et les médicaments les contenant. |
| FR2744361B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
| FR2744363B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application de derives de thiazolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
| FR2744362B1 (fr) * | 1996-02-07 | 1998-02-27 | Rhone Poulenc Rorer Sa | Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif |
| TW442449B (en) | 1996-07-04 | 2001-06-23 | Hoechst Ag | Process for preparing 1,2-dichloroethane by direct chlorination |
| JP2002501518A (ja) * | 1997-05-30 | 2002-01-15 | セルテック セラピューティックス リミテッド | 抗炎症性チロシン誘導体 |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| JP2002504534A (ja) | 1998-02-26 | 2002-02-12 | セルテック・セラピューティクス・リミテッド | α４インテグリンの阻害剤としてのフェニルアラニン誘導体 |
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| DE60130910T2 (de) | 2000-04-17 | 2008-07-10 | Ucb Pharma, S.A. | Enamin-derivate als zell-adhäsionsmoleküle |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| AU2001267753A1 (en) | 2000-07-07 | 2002-01-21 | Celltech R And D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
| EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
| JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| EP1723127A4 (en) * | 2004-02-11 | 2009-10-28 | Univ Ohio State Res Found | CELL PROLIFERATION INHIBITOR ANALOGS, METHODS OF MAKING SAME, AND USES THEREOF |
| US8247438B2 (en) * | 2008-02-27 | 2012-08-21 | Neuropill, Inc. | Methods for treating schizophrenia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2659653B1 (fr) * | 1990-03-13 | 1992-05-22 | Rhone Poulenc Sante | Derives de l'uree, leur preparation et les medicaments les contenant. |
| FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
-
1993
- 1993-01-07 FR FR9300076A patent/FR2700168B1/fr not_active Expired - Fee Related
-
1994
- 1994-01-03 KR KR1019950702796A patent/KR960700268A/ko not_active Withdrawn
- 1994-01-03 HU HU9502064A patent/HUT73428A/hu unknown
- 1994-01-03 EP EP94904199A patent/EP0679161B1/fr not_active Expired - Lifetime
- 1994-01-03 AT AT94904199T patent/ATE167681T1/de not_active IP Right Cessation
- 1994-01-03 ES ES94904199T patent/ES2119160T3/es not_active Expired - Lifetime
- 1994-01-03 DK DK94904199T patent/DK0679161T3/da active
- 1994-01-03 JP JP6515746A patent/JPH08507292A/ja active Pending
- 1994-01-03 AU AU58351/94A patent/AU5835194A/en not_active Abandoned
- 1994-01-03 US US08/446,745 patent/US5633270A/en not_active Expired - Fee Related
- 1994-01-03 NZ NZ259530A patent/NZ259530A/en unknown
- 1994-01-03 WO PCT/FR1994/000007 patent/WO1994015955A1/fr not_active Ceased
- 1994-01-03 DE DE69411260T patent/DE69411260T2/de not_active Expired - Fee Related
- 1994-01-03 CA CA002152184A patent/CA2152184A1/fr not_active Abandoned
- 1994-01-06 IL IL10828994A patent/IL108289A0/xx unknown
- 1994-01-06 ZA ZA9479A patent/ZA9479B/xx unknown
-
1995
- 1995-07-06 NO NO952687A patent/NO952687L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5835194A (en) | 1994-08-15 |
| FR2700168A1 (fr) | 1994-07-08 |
| HU9502064D0 (en) | 1995-09-28 |
| HUT73428A (en) | 1996-07-29 |
| JPH08507292A (ja) | 1996-08-06 |
| IL108289A0 (en) | 1994-04-12 |
| DE69411260D1 (de) | 1998-07-30 |
| FR2700168B1 (fr) | 1995-02-03 |
| WO1994015955A1 (fr) | 1994-07-21 |
| KR960700268A (ko) | 1996-01-19 |
| ATE167681T1 (de) | 1998-07-15 |
| NZ259530A (en) | 1996-06-25 |
| ZA9479B (en) | 1994-08-11 |
| NO952687L (no) | 1995-09-05 |
| DK0679161T3 (da) | 1999-02-01 |
| EP0679161B1 (fr) | 1998-06-24 |
| US5633270A (en) | 1997-05-27 |
| EP0679161A1 (fr) | 1995-11-02 |
| DE69411260T2 (de) | 1999-01-07 |
| CA2152184A1 (fr) | 1994-07-21 |
| NO952687D0 (no) | 1995-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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