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AU2001267753A1 - Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists - Google Patents

Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists

Info

Publication number
AU2001267753A1
AU2001267753A1 AU2001267753A AU6775301A AU2001267753A1 AU 2001267753 A1 AU2001267753 A1 AU 2001267753A1 AU 2001267753 A AU2001267753 A AU 2001267753A AU 6775301 A AU6775301 A AU 6775301A AU 2001267753 A1 AU2001267753 A1 AU 2001267753A1
Authority
AU
Australia
Prior art keywords
acid derivatives
heteroaromatic ring
derivatives containing
squaric acid
bicyclic heteroaromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001267753A
Inventor
Rikki Peter Alexander
Sarah Catherine Archibald
John Clifford Head
Barry John Langham
Janeen Marsha Linsley
John Robert Porter
Graham John Warrellow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celltech R&D Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016785A external-priority patent/GB0016785D0/en
Priority claimed from GB0028364A external-priority patent/GB0028364D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of AU2001267753A1 publication Critical patent/AU2001267753A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2001267753A 2000-07-07 2001-07-05 Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists Abandoned AU2001267753A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0016785 2000-07-07
GB0016785A GB0016785D0 (en) 2000-07-07 2000-07-07 Chemical compounds
GB0028364A GB0028364D0 (en) 2000-11-21 2000-11-21 Chemical compounds
GB0028364 2000-11-21
PCT/GB2001/003028 WO2002004426A1 (en) 2000-07-07 2001-07-05 Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists

Publications (1)

Publication Number Publication Date
AU2001267753A1 true AU2001267753A1 (en) 2002-01-21

Family

ID=26244624

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001267753A Abandoned AU2001267753A1 (en) 2000-07-07 2001-07-05 Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists

Country Status (5)

Country Link
US (1) US6740654B2 (en)
EP (1) EP1301488A1 (en)
JP (1) JP2004502762A (en)
AU (1) AU2001267753A1 (en)
WO (1) WO2002004426A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004021404D1 (en) 2004-12-23 2009-07-16 Gpc Biotech Ag Squaric acid derivatives with antiproliferative activity
US8450348B2 (en) 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
RU2529468C2 (en) 2008-06-24 2014-09-27 Топотаргет А/С 1, 2-dihydrocyclobutanedione derivatives as nicotinamide phosphoribosyltransferase inhibitors

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Also Published As

Publication number Publication date
JP2004502762A (en) 2004-01-29
US6740654B2 (en) 2004-05-25
WO2002004426A1 (en) 2002-01-17
US20020107263A1 (en) 2002-08-08
EP1301488A1 (en) 2003-04-16

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