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ES2036948A1 - Procedure for obtaining compounds derived from pyridine. - Google Patents

Procedure for obtaining compounds derived from pyridine.

Info

Publication number
ES2036948A1
ES2036948A1 ES919102594A ES9102594A ES2036948A1 ES 2036948 A1 ES2036948 A1 ES 2036948A1 ES 919102594 A ES919102594 A ES 919102594A ES 9102594 A ES9102594 A ES 9102594A ES 2036948 A1 ES2036948 A1 ES 2036948A1
Authority
ES
Spain
Prior art keywords
procedure
pyridine
compounds derived
obtaining compounds
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919102594A
Other languages
Spanish (es)
Other versions
ES2036948B1 (en
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GENESIS PARA LA INVESTIGACION
Original Assignee
GENESIS PARA LA INVESTIGACION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GENESIS PARA LA INVESTIGACION filed Critical GENESIS PARA LA INVESTIGACION
Priority to ES9102594A priority Critical patent/ES2036948B1/en
Priority to YU99792A priority patent/YU99792A/en
Priority to HRP921309 priority patent/HRP921309A2/en
Priority to SI9200336A priority patent/SI9200336A/en
Priority to ES9300064A priority patent/ES2066701B1/en
Priority to ES9300240A priority patent/ES2058027B1/en
Priority to ES9300935A priority patent/ES2067407B1/en
Publication of ES2036948A1 publication Critical patent/ES2036948A1/en
Application granted granted Critical
Publication of ES2036948B1 publication Critical patent/ES2036948B1/en
Priority to ES9402419A priority patent/ES2105953B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for obtaining compounds derived from pyridine with formula I, where X is N or CH triradical, R<1> is a hydrogen, methoxy, difluoromethoxy 2,2,2-trifluoroethoxy, isopropyloxy, 2-methylpropyloxy or cyclopropylmethyloxy radical, R<2> and R<3> are independently a hydrogen, methyl or methoxy radical, and R<4> is a 2,2,2-trifluoroethyl, ethyl, isopropyl, methyl or 3-methoxypropile radical, excepting the case in which simultaneously: X is -CH=, R<1> is MeO-, and R<2>, R<3> and R<4> are Me the procedure consists of at least 7 steps, the first being the N-oxidation of a methylpiridine with H2O2 and a catalyst, and the last an S-oxidation of a thioether with a peracid or with H2O2, a base and a catalyst.
ES9102594A 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. Expired - Fee Related ES2036948B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES9102594A ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
YU99792A YU99792A (en) 1991-11-21 1992-11-19 PROCEDURE FOR OBTAINING PYRIDINE DERIVATIVES
SI9200336A SI9200336A (en) 1991-11-21 1992-11-20 Method for pyridine derivatives preparation
HRP921309 HRP921309A2 (en) 1991-11-21 1992-11-20 A process for the preparation of pyridine derivatives
ES9300064A ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300240A ES2058027B1 (en) 1991-11-21 1993-02-09 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300935A ES2067407B1 (en) 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES.
ES9402419A ES2105953B1 (en) 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102594A ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Publications (2)

Publication Number Publication Date
ES2036948A1 true ES2036948A1 (en) 1993-06-01
ES2036948B1 ES2036948B1 (en) 1994-09-01

Family

ID=8274245

Family Applications (4)

Application Number Title Priority Date Filing Date
ES9102594A Expired - Fee Related ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300064A Expired - Fee Related ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300935A Expired - Fee Related ES2067407B1 (en) 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES.
ES9402419A Expired - Fee Related ES2105953B1 (en) 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES9300064A Expired - Fee Related ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300935A Expired - Fee Related ES2067407B1 (en) 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES.
ES9402419A Expired - Fee Related ES2105953B1 (en) 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Country Status (4)

Country Link
ES (4) ES2036948B1 (en)
HR (1) HRP921309A2 (en)
SI (1) SI9200336A (en)
YU (1) YU99792A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060541A1 (en) * 1993-02-26 1994-11-16 Vinas Lab New procedure for the synthesis of a derivative of 2-(2- pyridylmethylsulphinyl)benzimidazole, and new intermediate products obtained therewith
ES2063705A1 (en) * 1993-06-14 1995-01-01 S A L V A T Lab Sa Intermediate for the synthesis of lansoprazole and procedure for obtaining it
WO2001068594A1 (en) * 2000-03-13 2001-09-20 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
ES2166269A1 (en) * 1999-07-14 2002-04-01 Sint Quimica Sa Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles
ES2187248A1 (en) * 2000-08-25 2003-05-16 Sint Quimica Sa Procedure is for obtaining derivatives of 2-(2-pyridinyl methyl-sulphinyl)-benzimidazole to be used in treatment or prevention of peptic ulcers
JP2003531144A (en) * 2000-04-14 2003-10-21 エスティーブ キミカ ソシエダッド アノニマ Method for obtaining a derivative of [[(pyridyl-substituted) methyl] thio] benzimidazole
EP1334956A3 (en) * 2002-02-07 2004-02-11 Sumitomo Chemical Company, Limited Method for preparing sulfone or sulfoxide compound
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
WO2009066309A3 (en) * 2007-07-12 2010-01-07 Cadila Healthcare Limited Process for preparation of omeprazole
CN102267979A (en) * 2011-06-15 2011-12-07 扬州天和药业有限公司 Method for preparing lansoprazole
CN110317164A (en) * 2019-07-06 2019-10-11 抚州三和医药化工有限公司 A kind of preparation method of intermediate of omeprazole

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60316791T2 (en) 2002-08-21 2008-07-24 Teva Pharmaceutical Industries Ltd. PROCESS FOR PURIFYING LANZOPRAZOLE
EP1465890B1 (en) 2002-11-18 2007-04-04 Teva Pharmaceutical Industries Ltd. Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
CA2515130A1 (en) 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
US7601737B2 (en) 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
ES2363075B1 (en) * 2009-12-23 2012-03-27 Laboratorios Viñas S.A. Procedure for obtaining 4-chloro-2-chloromethyl-3-methylpyridine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204879D0 (en) * 1982-08-26 1982-08-26 Haessle Ab NOVEL CHEMICAL INTERMEDIATES
JPS6150978A (en) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
ES8604202A1 (en) * 1985-06-01 1986-01-16 Rubio Lab PROCEDURE FOR OBTAINING A BENZIMIDAZOLIC DERIVATIVE
US4851419A (en) * 1985-10-16 1989-07-25 Fisons Plc Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
JPS62209062A (en) * 1986-03-10 1987-09-14 Yamanouchi Pharmaceut Co Ltd 2-pyridylmethylthio-or 2-pyridylmethylsulfinyl-substituted condensed ring compound
ES2024357A6 (en) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060541A1 (en) * 1993-02-26 1994-11-16 Vinas Lab New procedure for the synthesis of a derivative of 2-(2- pyridylmethylsulphinyl)benzimidazole, and new intermediate products obtained therewith
ES2063705A1 (en) * 1993-06-14 1995-01-01 S A L V A T Lab Sa Intermediate for the synthesis of lansoprazole and procedure for obtaining it
ES2166269A1 (en) * 1999-07-14 2002-04-01 Sint Quimica Sa Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles
AU2001237452B2 (en) * 2000-03-13 2005-01-13 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
WO2001068594A1 (en) * 2000-03-13 2001-09-20 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
ES2163372A1 (en) * 2000-03-13 2002-01-16 Esteve Quimica Sa Method for oxidizing a thioether group into a sulfoxide group
AU2001237452B9 (en) * 2000-03-13 2005-01-27 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
US6603009B2 (en) * 2000-03-13 2003-08-05 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
JP2003527370A (en) * 2000-03-13 2003-09-16 エステベ・キミカ・ソシエダッド・アノニマ Method for oxidizing thioether groups to sulfoxide groups
JP2003531144A (en) * 2000-04-14 2003-10-21 エスティーブ キミカ ソシエダッド アノニマ Method for obtaining a derivative of [[(pyridyl-substituted) methyl] thio] benzimidazole
ES2187248A1 (en) * 2000-08-25 2003-05-16 Sint Quimica Sa Procedure is for obtaining derivatives of 2-(2-pyridinyl methyl-sulphinyl)-benzimidazole to be used in treatment or prevention of peptic ulcers
EP1334956A3 (en) * 2002-02-07 2004-02-11 Sumitomo Chemical Company, Limited Method for preparing sulfone or sulfoxide compound
US6916938B2 (en) 2002-02-07 2005-07-12 Sumitomo Chemical Company, Limited Method for preparing sulfone or sulfoxide compound
WO2009066309A3 (en) * 2007-07-12 2010-01-07 Cadila Healthcare Limited Process for preparation of omeprazole
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
CN102267979A (en) * 2011-06-15 2011-12-07 扬州天和药业有限公司 Method for preparing lansoprazole
CN110317164A (en) * 2019-07-06 2019-10-11 抚州三和医药化工有限公司 A kind of preparation method of intermediate of omeprazole
CN110317164B (en) * 2019-07-06 2022-08-19 抚州三和医药化工有限公司 Preparation method of omeprazole intermediate

Also Published As

Publication number Publication date
ES2067407B1 (en) 1996-04-16
ES2066701A1 (en) 1995-03-01
YU99792A (en) 1995-10-03
SI9200336A (en) 1993-06-30
ES2066701B1 (en) 1995-12-01
ES2067407A1 (en) 1995-03-16
HRP921309A2 (en) 1995-02-28
ES2105953B1 (en) 1998-07-01
ES2105953A1 (en) 1997-10-16
ES2036948B1 (en) 1994-09-01

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