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ES2009238A6 - Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas. - Google Patents

Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.

Info

Publication number
ES2009238A6
ES2009238A6 ES8800574A ES8800574A ES2009238A6 ES 2009238 A6 ES2009238 A6 ES 2009238A6 ES 8800574 A ES8800574 A ES 8800574A ES 8800574 A ES8800574 A ES 8800574A ES 2009238 A6 ES2009238 A6 ES 2009238A6
Authority
ES
Spain
Prior art keywords
peptides
disclosed
proteins
mycobacterial
recombinants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800574A
Other languages
English (en)
Inventor
Thomas Shinnick
Richard Houghten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of ES2009238A6 publication Critical patent/ES2009238A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

METODO PARA PRODUCIR PROTEINAS DE MYCOBACTERIUM TUBERCULOSIS Y PEPTIDOS ANTIGENICOS DE LAS MISMAS. LAS PROTEINAS DE INTERES TIENEN ENTRE 517 Y 540 RESTOS DE AMINOACIDOS Y SE OBTIENEN POR CULTIVO DE UN MEDIO DE REPLICACION/EXPRESION QUE CONTIENE UN PLASMIDO CON UNA SECUENCIA DE ADN EXTRAÑO QUE CONSTA DE LA SECUENCIA NUCLEOTIDICA COMPRENDIDA ENTRE LAS POSICIONES 3950 Y 2390 LEIDA DE IZQUIERDA A DERECHA Y DESDE EL EXTREMO 5'' AL 3'' DEL GENOMA DE M. TUBERCULOSIS Y POSTERIOR RECOLECCION DE LA PROTEINA EXPRESADA. LOS PEPTIDOS ANTIGENICOS CONSTAN DE UNA SECUENCIA DE 5 A 40 RESTOS AMINOACIDOS CORRESPONDIENTES A LA PROTEINA DE 540 O DE 517 AMINOACIDOS Y SE OBTIENEN POR SINTESIS QUIMICA. ESTAS PROTEINAS Y PEPTIDOS SON ADECUADOS PARA ANALIZAR LA PRESENCIA DE ANTICUERPOS FRENTE A M. TUBERCULOSIS Y PARA LA PREPARACION DE EQUIPOS DE DIAGNOSTICO.
ES8800574A 1987-02-26 1988-02-26 Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas. Expired ES2009238A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/019,529 US4952395A (en) 1987-02-26 1987-02-26 Mycobacterial recombinants and peptides

Publications (1)

Publication Number Publication Date
ES2009238A6 true ES2009238A6 (es) 1989-09-16

Family

ID=21793686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800574A Expired ES2009238A6 (es) 1987-02-26 1988-02-26 Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.

Country Status (8)

Country Link
US (1) US4952395A (es)
CA (1) CA1340423C (es)
ES (1) ES2009238A6 (es)
GR (1) GR1000083B (es)
NZ (1) NZ223632A (es)
PT (1) PT86838B (es)
WO (1) WO1988006591A1 (es)
ZA (1) ZA881344B (es)

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US7300660B2 (en) * 1993-11-23 2007-11-27 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
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US6613881B1 (en) 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
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US20040013685A1 (en) * 1997-11-10 2004-01-22 Peter Andersen Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
US6497880B1 (en) 1998-12-08 2002-12-24 Stressgen Biotechnologies Corporation Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
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US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
CA2386841A1 (en) * 1999-10-07 2001-04-12 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
JP2003519668A (ja) 2000-01-14 2003-06-24 ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ 熱ショックタンパク質融合タンパク質による、ｃｄ４＋ｔ細胞非依存性のインビボｃｔｌ惹起による個別ａｔｐ結合ドメインのマッピング
WO2001062893A2 (en) 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
ATE442866T1 (de) * 2000-06-20 2009-10-15 Corixa Corp Fusionsproteine aus mycobakterium tuberculosis
PL359930A1 (en) 2000-06-26 2004-09-06 Stressgen Biotechnologies Corporation Human papilloma virus treatment
WO2002004018A2 (en) * 2000-07-10 2002-01-17 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
EP1353686A4 (en) * 2000-12-13 2004-04-07 Argonex Pharmaceuticals PEPTIDES ASSOCIATED WITH CLASS I OF THE MAJOR HISTOCOMPATIBILITY COMPLEX AND USEFUL IN THE PREVENTION AND TREATMENT OF TUBERCULOSIS
EP1357940A4 (en) 2001-02-05 2004-03-17 Stressgen Biotechnologies Corp HEPATITIS? B? VIRUS THERAPY
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PL239045B1 (pl) * 2018-01-09 2021-11-02 Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk Epitop specyficzny dla zakaźnych Streptococcus agalactiae oraz sposób wykrywania zakażenia pacjenta szczepem Streptococcus agalactiae

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NL8701163A (nl) * 1986-09-09 1988-04-05 Nederlanden Staat Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits.
EP0345299A1 (en) * 1987-02-02 1989-12-13 Whitehead Institute For Biomedical Research Mycobacterium tuberculosis genes encoding protein antigens

Also Published As

Publication number Publication date
GR880100104A (en) 1988-12-16
PT86838B (pt) 1992-05-29
NZ223632A (en) 1991-03-26
CA1340423C (en) 1999-03-09
ZA881344B (en) 1988-08-26
PT86838A (pt) 1988-03-01
US4952395A (en) 1990-08-28
GR1000083B (el) 1990-11-29
WO1988006591A1 (en) 1988-09-07

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Effective date: 20141120