ES2007808A6 - Piperidinyl-alkyl urea deriv. prepn. - Google Patents
Piperidinyl-alkyl urea deriv. prepn.Info
- Publication number
- ES2007808A6 ES2007808A6 ES8800985A ES8800985A ES2007808A6 ES 2007808 A6 ES2007808 A6 ES 2007808A6 ES 8800985 A ES8800985 A ES 8800985A ES 8800985 A ES8800985 A ES 8800985A ES 2007808 A6 ES2007808 A6 ES 2007808A6
- Authority
- ES
- Spain
- Prior art keywords
- piperidinyl
- prepn
- alkyl urea
- urea deriv
- deriv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004202 carbamide Substances 0.000 title abstract 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- -1 4-piperidinyl alkyl amines Chemical class 0.000 abstract 1
- 102000003834 Histamine H1 Receptors Human genes 0.000 abstract 1
- 108090000110 Histamine H1 Receptors Proteins 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The derivs. of 4-piperidinyl alkyl urea of formula (I) and their acceptable salts, for use as specific antagonists of the H1 receptors of histamine, are made by reaction of 4-piperidinyl alkyl amines with isocyanates.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8800985A ES2007808A6 (en) | 1988-03-30 | 1988-03-30 | Piperidinyl-alkyl urea deriv. prepn. |
| PT8809388A PT88093B (en) | 1988-03-30 | 1988-07-22 | PROCESS FOR THE PREPARATION OF NEW 4-PIPERIDINOALCILLARY DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8800985A ES2007808A6 (en) | 1988-03-30 | 1988-03-30 | Piperidinyl-alkyl urea deriv. prepn. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2007808A6 true ES2007808A6 (en) | 1989-07-01 |
Family
ID=8255623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8800985A Expired ES2007808A6 (en) | 1988-03-30 | 1988-03-30 | Piperidinyl-alkyl urea deriv. prepn. |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2007808A6 (en) |
| PT (1) | PT88093B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078101A3 (en) * | 2003-03-08 | 2005-02-17 | Glaxo Group Ltd | Urea derivatives having vanilloid receptor antagonist activity |
| US6919356B2 (en) | 2002-09-26 | 2005-07-19 | Bristol Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| US7514562B2 (en) | 2003-03-07 | 2009-04-07 | Glaxo Group Limited | Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain |
| US7528151B2 (en) | 2003-03-06 | 2009-05-05 | Glaxo Group Limited | Heterocyclic urea derivatives for the treatment of pain |
-
1988
- 1988-03-30 ES ES8800985A patent/ES2007808A6/en not_active Expired
- 1988-07-22 PT PT8809388A patent/PT88093B/en not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919356B2 (en) | 2002-09-26 | 2005-07-19 | Bristol Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| US7528151B2 (en) | 2003-03-06 | 2009-05-05 | Glaxo Group Limited | Heterocyclic urea derivatives for the treatment of pain |
| US7514562B2 (en) | 2003-03-07 | 2009-04-07 | Glaxo Group Limited | Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain |
| WO2004078101A3 (en) * | 2003-03-08 | 2005-02-17 | Glaxo Group Ltd | Urea derivatives having vanilloid receptor antagonist activity |
| US7528150B2 (en) | 2003-03-08 | 2009-05-05 | Glaxo Group Limited | Urea derivatives having vanilloid receptor antagonist activity |
Also Published As
| Publication number | Publication date |
|---|---|
| PT88093A (en) | 1989-11-10 |
| PT88093B (en) | 1994-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2008-03-30 |