TR200000333T2 - 4-aminopyrol (3,2-d) pyrimidines as Y receptor antagonists. - Google Patents
4-aminopyrol (3,2-d) pyrimidines as Y receptor antagonists.Info
- Publication number
- TR200000333T2 TR200000333T2 TR2000/00333T TR200000333T TR200000333T2 TR 200000333 T2 TR200000333 T2 TR 200000333T2 TR 2000/00333 T TR2000/00333 T TR 2000/00333T TR 200000333 T TR200000333 T TR 200000333T TR 200000333 T2 TR200000333 T2 TR 200000333T2
- Authority
- TR
- Turkey
- Prior art keywords
- aminopyrol
- pyrimidines
- receptor antagonists
- neuropeptide
- excess
- Prior art date
Links
- BOCGZRRTIITFTE-UHFFFAOYSA-N 4-amino-2h-pyran-2-ol Chemical compound NC1=CC(O)OC=C1 BOCGZRRTIITFTE-UHFFFAOYSA-N 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 101710151321 Melanostatin Proteins 0.000 abstract 1
- 102400000064 Neuropeptide Y Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Nöropeptid Y'nin fazlaligiyla iliskilendirilen kosullarin tedavisi için formül (I) bilesimleriCompounds of formula (I) for the treatment of conditions associated with an excess of neuropeptide Y
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5473497P | 1997-08-05 | 1997-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000333T2 true TR200000333T2 (en) | 2000-05-22 |
Family
ID=21993163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00333T TR200000333T2 (en) | 1997-08-05 | 1998-07-10 | 4-aminopyrol (3,2-d) pyrimidines as Y receptor antagonists. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6187778B1 (en) |
| EP (1) | EP1003744B1 (en) |
| JP (1) | JP3711238B2 (en) |
| KR (1) | KR20010022583A (en) |
| CN (1) | CN1264381A (en) |
| AP (1) | AP9801312A0 (en) |
| AT (1) | ATE296825T1 (en) |
| AU (1) | AU7927498A (en) |
| BG (1) | BG104107A (en) |
| BR (1) | BR9811844A (en) |
| CA (1) | CA2293621C (en) |
| CO (1) | CO4960634A1 (en) |
| DE (1) | DE69830409T2 (en) |
| EA (1) | EA200000098A1 (en) |
| ES (1) | ES2241146T3 (en) |
| GT (1) | GT199800114A (en) |
| HR (1) | HRP980434A2 (en) |
| HU (1) | HUP0002956A3 (en) |
| ID (1) | ID24300A (en) |
| IL (1) | IL133430A0 (en) |
| IS (1) | IS5294A (en) |
| MA (1) | MA24629A1 (en) |
| NO (1) | NO996178L (en) |
| OA (1) | OA11277A (en) |
| PA (1) | PA8456601A1 (en) |
| PE (1) | PE106199A1 (en) |
| PL (1) | PL338575A1 (en) |
| SA (1) | SA98190435A (en) |
| TN (1) | TNSN98148A1 (en) |
| TR (1) | TR200000333T2 (en) |
| WO (1) | WO1999007703A1 (en) |
| ZA (1) | ZA986968B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| KR20020047201A (en) * | 1999-09-30 | 2002-06-21 | 해피 페너 ; 해리 에이치. 페너 2세 | AMINO SUBSTITUTED PYRAZOLO[1,5-a]-1,5-PYRIMIDINES AND PYRAZOLO[1,5-a]-1,3,5-TRIAZINES |
| CN1615873A (en) * | 1999-12-24 | 2005-05-18 | 阿文蒂斯药物有限公司 | Azaindoles compound |
| GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| US7507740B2 (en) | 2004-06-02 | 2009-03-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| MXPA06014798A (en) | 2004-06-17 | 2007-06-22 | Wyeth Corp | Gonadotropin releasing hormone receptor antagonists. |
| RU2007101509A (en) | 2004-06-17 | 2008-07-27 | Уайт (Us) | METHOD FOR PRODUCING HORMONE RECEPTOR ANTAGONISTS RELEASING GONADOTROPINE |
| MX2007001399A (en) * | 2004-08-02 | 2007-04-18 | Osi Pharm Inc | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds. |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| KR20060087386A (en) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | Novel benzoimidazole derivatives and pharmaceutical compositions containing them |
| PL1861387T3 (en) * | 2005-01-28 | 2014-08-29 | Dae Woong Pharma | Benzimidazole derivatives and pharmaceutical compositions thereof |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| WO2006108218A1 (en) * | 2005-04-15 | 2006-10-19 | Regenertech Pty Limited | Use of neuropeptide y (npy) and agonists and antagonists thereof for tissue regeneration |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| WO2007007910A1 (en) * | 2005-07-13 | 2007-01-18 | Banyu Pharmaceutical Co., Ltd. | Heterocycle-substituted benzimidazole derivative |
| UY29825A1 (en) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | SUBSTITUTED DERIVATIVES OF 3H-IMIDAZOL- (4.5 B (BETA)) PIRIDINA-2-IL BENZOATES AND BENZAMIDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS |
| AR057525A1 (en) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | GSK3 SELECTIVE INHIBITING COMPOUNDS AND A PROCESS FOR PREPARATION |
| US20070129364A1 (en) * | 2005-12-07 | 2007-06-07 | Han-Qing Dong | Pyrrolopyridine kinase inhibiting compounds |
| ES2526813T3 (en) * | 2005-12-22 | 2015-01-15 | Cancer Research Technology Limited | Enzyme inhibitors |
| KR20080085232A (en) | 2006-02-17 | 2008-09-23 | 화이자 리미티드 | 3-deazapurine derivatives as TLR7 modulators |
| JP5606734B2 (en) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | Pharmaceutical compounds |
| EP2054405B1 (en) | 2006-07-11 | 2013-09-18 | Daewoong Pharmaceutical Co., Ltd. | Novel biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same |
| KR101134239B1 (en) | 2006-07-11 | 2012-04-10 | 주식회사 대웅제약 | Novel biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same |
| CL2007002617A1 (en) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | COMPOUNDS DERIVED FROM PIRROLO [2,3-B] PIRAZIN-6-ILO; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT INFLAMMATION OF THE ARTICULATIONS, Rheumatoid Arthritis, TUMORS, LYMPHOMA OF THE CELLS OF THE MANTO. |
| WO2008121064A1 (en) * | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705 |
| DE102007027800A1 (en) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituted bicyclic heteroaryl compounds and their use |
| JP4705695B2 (en) | 2007-10-11 | 2011-06-22 | アストラゼネカ アクチボラグ | Pyrrolo [2,3-D] pyrimidine derivatives as protein kinase B inhibitors |
| CA2711777A1 (en) | 2008-01-11 | 2009-08-13 | Natco Pharma Limited | Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer drugs |
| PH12013502048B1 (en) | 2011-04-01 | 2018-07-11 | Astrazeneca Ab | Therapeutic treatment |
| AU2012321110B2 (en) | 2011-11-30 | 2014-10-23 | Astrazeneca Ab | Combination treatment |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| JP7530360B2 (en) * | 2018-11-30 | 2024-08-07 | 武田薬品工業株式会社 | TYK2 INHIBITORS AND USES THEREOF |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274213A (en) | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
| DE2818676A1 (en) * | 1978-04-27 | 1979-11-08 | Troponwerke Gmbh & Co Kg | SUBSTITUTED 5,6-DIMETHYLPYRROLO 2,3-D PYRIMIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT |
| GB9022644D0 (en) * | 1990-10-18 | 1990-11-28 | Ici Plc | Heterocyclic compounds |
| US5877178A (en) * | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
| US5235053A (en) * | 1992-06-22 | 1993-08-10 | Eli Lilly And Company | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates |
| US5284971A (en) | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
| DK0580550T3 (en) | 1992-07-21 | 1998-02-02 | Ciba Geigy Ag | Oxamic acid derivatives as hypercholesterolemic agents |
| DK0682027T3 (en) * | 1994-05-03 | 1998-05-04 | Ciba Geigy Ag | Pyrrolopyrimidine derivatives with antiproliferative action |
| CN1046731C (en) * | 1994-09-29 | 1999-11-24 | 诺瓦蒂斯有限公司 | Pyrrolo[2,3-d]pyrimidine compounds and their applications |
| US6562862B1 (en) | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
| BR9509610A (en) | 1994-11-07 | 1997-10-28 | Pfizer | Y1-specific neuropeptide ligands |
| US5644057A (en) * | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| EP0759441A3 (en) | 1995-06-30 | 1999-06-30 | Eli Lilly And Company | Methods of treating neuropeptide Y-associated conditions |
| WO1997025041A1 (en) * | 1996-01-09 | 1997-07-17 | Eli Lilly And Company | Benzimidzolyl neuropeptide y receptor antagonists |
-
1998
- 1998-07-10 ID IDW20000021A patent/ID24300A/en unknown
- 1998-07-10 CN CN98807398A patent/CN1264381A/en active Pending
- 1998-07-10 JP JP2000506207A patent/JP3711238B2/en not_active Expired - Fee Related
- 1998-07-10 AT AT98929573T patent/ATE296825T1/en not_active IP Right Cessation
- 1998-07-10 EA EA200000098A patent/EA200000098A1/en unknown
- 1998-07-10 HU HU0002956A patent/HUP0002956A3/en unknown
- 1998-07-10 EP EP98929573A patent/EP1003744B1/en not_active Expired - Lifetime
- 1998-07-10 IL IL13343098A patent/IL133430A0/en unknown
- 1998-07-10 US US09/380,901 patent/US6187778B1/en not_active Expired - Fee Related
- 1998-07-10 ES ES98929573T patent/ES2241146T3/en not_active Expired - Lifetime
- 1998-07-10 AU AU79274/98A patent/AU7927498A/en not_active Abandoned
- 1998-07-10 DE DE69830409T patent/DE69830409T2/en not_active Expired - Fee Related
- 1998-07-10 WO PCT/IB1998/001053 patent/WO1999007703A1/en not_active Ceased
- 1998-07-10 CA CA002293621A patent/CA2293621C/en not_active Expired - Fee Related
- 1998-07-10 PL PL98338575A patent/PL338575A1/en unknown
- 1998-07-10 KR KR1020007001174A patent/KR20010022583A/en not_active Ceased
- 1998-07-10 TR TR2000/00333T patent/TR200000333T2/en unknown
- 1998-07-10 BR BR9811844-7A patent/BR9811844A/en not_active Application Discontinuation
- 1998-07-27 GT GT199800114A patent/GT199800114A/en unknown
- 1998-07-30 PE PE1998000678A patent/PE106199A1/en not_active Application Discontinuation
- 1998-07-30 AP APAP/P/1998/001312A patent/AP9801312A0/en unknown
- 1998-08-03 PA PA19988456601A patent/PA8456601A1/en unknown
- 1998-08-04 ZA ZA9806968A patent/ZA986968B/en unknown
- 1998-08-04 MA MA25203A patent/MA24629A1/en unknown
- 1998-08-04 HR HR60/054,734A patent/HRP980434A2/en not_active Application Discontinuation
- 1998-08-04 TN TNTNSN98148A patent/TNSN98148A1/en unknown
- 1998-08-05 CO CO98044925A patent/CO4960634A1/en unknown
- 1998-08-19 SA SA98190435A patent/SA98190435A/en unknown
-
1999
- 1999-12-10 IS IS5294A patent/IS5294A/en unknown
- 1999-12-14 NO NO996178A patent/NO996178L/en not_active Application Discontinuation
-
2000
- 2000-01-14 OA OA1200000007A patent/OA11277A/en unknown
- 2000-01-26 BG BG104107A patent/BG104107A/en unknown
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