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ES2005753A6 - Procedimiento para la preparacion de polipeptidos inmunologicamente activos utiles para la obtencion de vacunas antimalaria y para la deteccion de enfermedades paludicas. - Google Patents

Procedimiento para la preparacion de polipeptidos inmunologicamente activos utiles para la obtencion de vacunas antimalaria y para la deteccion de enfermedades paludicas.

Info

Publication number
ES2005753A6
ES2005753A6 ES8703801A ES8703801A ES2005753A6 ES 2005753 A6 ES2005753 A6 ES 2005753A6 ES 8703801 A ES8703801 A ES 8703801A ES 8703801 A ES8703801 A ES 8703801A ES 2005753 A6 ES2005753 A6 ES 2005753A6
Authority
ES
Spain
Prior art keywords
asn
preparation
detection
immunologically active
diagnostic kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8703801A
Other languages
English (en)
Inventor
Adriano Bernardi
Fabio Bonelli
Antonello Pessi
Antonio Silvio Verdini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eni Tecnologie SpA
Original Assignee
Eniricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche SpA filed Critical Eniricerche SpA
Publication of ES2005753A6 publication Critical patent/ES2005753A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE POLIPEPTIDOS INMUNOLOGICAMENTE ACTIVOS CONSTITUIDOS POR UNA SECUENCIA ASN-VAL-ASP-PRO-ASN-ALA-ASN-PRO QUE SE REPITE 3 VECES Y POR LOS MENOS 3 CUADRUPLETES CON UNA SECUENCIA ASN-ALA-ASN-PRO, VINCULADOS ENTRE SI MEDIANTE ENLACES AMIDICOS ENTRE LA PROLINA TERMINAL DE LA PRIMERA SECUENCIA Y LA ASPARAGINA INICIAL DEL PRIMER CUADRUPLETE, CONSISTENTE EN UN PROCESO DE SINTESIS EN FASE SOLIDA QUE COMPRENDE UNA SERIE DE CONDENSACIONES SUCESIVAS DE DIVERSOS AMINOACIDOS A UN SOPORTE SOLIDO INSOLUBLE MEDIANTE RESPECTIVAS REACCIONES DE ESTERIFICACION Y ACILACION, EL DESBLOQUEO DEL POLIPEPTIDO ASI OBTENIDO DEL SOPORTE SOLIDO INSOLUBLE MEDIANTE HIDROLISIS ACIDA, Y SU RECUPERACION Y PURIFICACION MEDIANTE CROMATOGRAFIA.DICHOS POLIPEPTIDOS SON UTILES PARA LA PREPARACION DE VACUNAS ANTIMALARIA Y DE CONJUNTOS DE DIAGNOSTICO PARA LA DETERMINACION DE ANTICUERPOS ANTIESPOROZOITOS EN MUESTRAS CLINICAS DE INDIVIDUOS ENFERMOS DE MALARIA.
ES8703801A 1986-12-04 1987-12-04 Procedimiento para la preparacion de polipeptidos inmunologicamente activos utiles para la obtencion de vacunas antimalaria y para la deteccion de enfermedades paludicas. Expired ES2005753A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22560/86A IT1198225B (it) 1986-12-04 1986-12-04 Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita

Publications (1)

Publication Number Publication Date
ES2005753A6 true ES2005753A6 (es) 1989-03-16

Family

ID=11197840

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8703801A Expired ES2005753A6 (es) 1986-12-04 1987-12-04 Procedimiento para la preparacion de polipeptidos inmunologicamente activos utiles para la obtencion de vacunas antimalaria y para la deteccion de enfermedades paludicas.

Country Status (16)

Country Link
US (1) US4843146A (es)
AR (1) AR247405A1 (es)
AT (1) AT398426B (es)
BE (1) BE1001692A5 (es)
CA (1) CA1304888C (es)
CH (1) CH672491A5 (es)
DE (1) DE3741183A1 (es)
ES (1) ES2005753A6 (es)
FR (1) FR2607703B1 (es)
GB (1) GB2199038B (es)
GR (1) GR871850B (es)
IT (1) IT1198225B (es)
NL (1) NL8702921A (es)
OA (1) OA08782A (es)
SE (1) SE8704765L (es)
ZA (1) ZA878903B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1198233B (it) * 1986-12-23 1988-12-21 Eniricerche Spa Metodo per la determinazione di anticorpi antisporozoita di p. falciparum nel sangue umano
IT1223301B (it) * 1987-09-11 1990-09-19 Eniricerche Spa Polipeptidi sequenziali immunologicamente attivi
IT1217582B (it) * 1988-05-13 1990-03-30 Eniricerche Spa Metodo immunoenzimatico in fase omogenea per la determinazione di anticorpi antisporozoita di plasmodium falciparum nel sangue umano
US5028425A (en) * 1988-07-07 1991-07-02 The United States Of America As Represented By The Department Of Health And Human Services Synthetic vaccine against P. falciparum malaria
ES2055785T3 (es) * 1989-01-17 1994-09-01 Eniricerche Spa Peptidos sinteticos y su uso como vehiculos universales para la preparacion de conjugados inmunogenos aptos para el desarrollo de vacunas sinteticas.
ES2063901T3 (es) * 1989-05-19 1995-01-16 Eniricerche Spa Compuestos inmunogenos y su uso en la preparacion de vacunas sinteticas geneticamente no restringidas y en la determinacion inmunoenzimatica de anticuerpos antiesporozoito de plasmodium malariae.
IT1237764B (it) * 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
US6942866B2 (en) * 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707357A (en) * 1984-06-26 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
CN86100979A (zh) * 1985-02-07 1986-12-17 史密丝克莱恩贝克曼公司 疟疾疫苗的制备方法
AU4723999A (en) * 1998-06-29 2000-01-17 Sbc Technology Resources, Inc. Emergency facility information system and methods

Also Published As

Publication number Publication date
IT1198225B (it) 1988-12-21
BE1001692A5 (fr) 1990-02-13
CA1304888C (en) 1992-07-07
GB2199038B (en) 1991-03-20
OA08782A (en) 1989-03-31
IT8622560A0 (it) 1986-12-04
DE3741183A1 (de) 1988-06-09
ATA319087A (de) 1994-04-15
US4843146A (en) 1989-06-27
CH672491A5 (es) 1989-11-30
SE8704765L (sv) 1988-06-05
DE3741183C2 (es) 1991-06-06
GR871850B (en) 1988-03-24
SE8704765D0 (sv) 1987-11-30
AR247405A1 (es) 1994-12-29
FR2607703B1 (fr) 1993-09-24
GB8728000D0 (en) 1988-01-06
NL8702921A (nl) 1988-07-01
ZA878903B (en) 1988-05-26
GB2199038A (en) 1988-06-29
FR2607703A1 (fr) 1988-06-10
AT398426B (de) 1994-12-27

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-12-04

FD1A Patent lapsed

Effective date: 20010402