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ES2002420A6 - Procedimiento para la preparacion de derivados del oxazol e isoxazol - Google Patents

Procedimiento para la preparacion de derivados del oxazol e isoxazol

Info

Publication number
ES2002420A6
ES2002420A6 ES8602629A ES8602629A ES2002420A6 ES 2002420 A6 ES2002420 A6 ES 2002420A6 ES 8602629 A ES8602629 A ES 8602629A ES 8602629 A ES8602629 A ES 8602629A ES 2002420 A6 ES2002420 A6 ES 2002420A6
Authority
ES
Spain
Prior art keywords
group
ilo
alkyl
formula
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602629A
Other languages
English (en)
Inventor
Peter James Machin
John Mervyn Osbond
Christopher Ray Self
Carey Ernest Smithen
Brian Peter Tong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858525578A external-priority patent/GB8525578D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2002420A6 publication Critical patent/ES2002420A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL OXAZOL E ISOXAZOL, DE FORMULA (I) EN DONDE A SIGNIFICA C1-6-ALQUILENO, HET SIGNIFICA UN GRUPO DE 2-R-OXAZOL-5-ILO,5-R-OZAXOL-2-ILO,4-R-XAZOL-2-ILO,2-R-OXAZOL-4-ILO,3-R-ISOXAZOL-5-ILO O 5-R-ISOXAZOL-3-ILO QUE ESTA OPCIONALMENTE SUSTITUIDO EN EL ANILLO HETEROCICLICO POR UN GRUPO DE C1-6-ALQUILO, R SIGNIFICA FENILO O TIENILO MONOSUSTITUIDO O DISUSTITUIDO POR HALOGENO, TRIFLUOROMETILO O C1-6-ALQUILTIO, R1 Y R2 SIGNIFICAN CADA UNO UN GRUPO C1-6-ALQUILO Y R3 SIGNIFICA UN GRUPO DE HIDROXILO O C1-6-ALCOXILO O UN GRUPO DE LA FORMULA -NR4R5 EN DONDE R4 Y R5 SIGNIFICAN CADA UNO UN ATOMO DE HIDROGENO O UN GRUPO DE C1-6-ALQUILO O R4 Y R5 JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS SIGNIFICAN UN ANILLO HETEROMONOCICLICO SATURADO PENTAGONAL O HEXAGONAL QUE PUEDE CONTENER UN ATOMO DE OXIGENO O AZUFRE O UN ATOMO DE NITROGENO ADICIONAL, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS DE LA FORMULA I EN DONDE R3 SIGNIFICA UN GRUPO HIDROXILICO CON BASES. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UN ALCOHOL DE FORMULA GENERAL (II) CON UNA CETONA, DE FORMULA GENERAL (III), EN PRESENCIA DE DISOLVENTE ORGANICO A TEMPERATURA DE REFLUJO, EN PRESENCIA DE UN ALCANO TRIHALOGENADO O TETRAHALOGENADO Y UNA BASE FUERTE. ESTOS PRODUCTOS TIENEN VALIOSAS PROPIEDADES FARMACOLOGICAS, ESPECIALMENTE ANTI-ARTRITICA.
ES8602629A 1985-10-17 1986-10-16 Procedimiento para la preparacion de derivados del oxazol e isoxazol Expired ES2002420A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858525578A GB8525578D0 (en) 1985-10-17 1985-10-17 Heterocyclic compounds
GB868617503A GB8617503D0 (en) 1985-10-17 1986-07-17 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2002420A6 true ES2002420A6 (es) 1988-08-01

Family

ID=26289895

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8602629A Expired ES2002420A6 (es) 1985-10-17 1986-10-16 Procedimiento para la preparacion de derivados del oxazol e isoxazol
ES8801315A Expired ES2010537A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de derivados de oxazol e isoxazol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES8801315A Expired ES2010537A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de derivados de oxazol e isoxazol.

Country Status (18)

Country Link
US (1) US4774253A (es)
EP (1) EP0220573B1 (es)
AU (1) AU594382B2 (es)
CA (1) CA1287058C (es)
CS (1) CS255881B2 (es)
DE (1) DE3682873D1 (es)
DK (1) DK470886A (es)
ES (2) ES2002420A6 (es)
FI (1) FI864052A7 (es)
HU (1) HU195792B (es)
IL (1) IL80290A (es)
MC (1) MC1770A1 (es)
NO (1) NO167284C (es)
NZ (1) NZ217871A (es)
PH (1) PH23022A (es)
PT (1) PT83565B (es)
SU (1) SU1514245A3 (es)
ZW (1) ZW19786A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149820A (en) * 1987-03-11 1992-09-22 Norsk Hydro A.S. Deuterated compounds
US5239080A (en) * 1989-02-08 1993-08-24 Takeda Chemical Industries, Ltd. Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents
US5114960A (en) * 1989-07-20 1992-05-19 Hoffmann-La Roche Inc. Substituted isoxazole derivatives
EP0440183A1 (en) * 1990-02-01 1991-08-07 Takeda Chemical Industries, Ltd. Oxazole compounds, their production and use
US5348969A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Diphenyloxazolyl-oxazoles as platelet aggregation inhibitors
FR2699172B1 (fr) * 1992-12-11 1995-01-20 Adir Nouveaux dérivés de 4-méthyl-1,3-oxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
ES2125161B1 (es) * 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
CA2268394C (en) 1996-10-14 2008-03-25 Bayer Aktiengesellschaft New heterocyclylmethyl-substituted pyrazol derivates
BR9906312A (pt) * 1998-03-30 2000-07-11 Japan Tobacco Inc Método de produção de composto de isoxazolidinadiona
HUP0302397A3 (en) * 2000-05-26 2007-02-28 Nippon Shinyaku Co Ltd Heterocyclic compounds and pharmaceutical compositions containing them
DE60317365T2 (de) * 2002-11-08 2008-08-21 F. Hoffmann-La Roche Ag Substituierte 4-alkoxyoxazol derivate als ppar agonisten
GB0712653D0 (en) 2007-06-28 2007-08-08 Syngenta Ltd Novel herbicides
WO2013185976A1 (en) * 2012-05-03 2013-12-19 Dsm Ip Assets B.V. A new process for preparation of 4-methyloxazole-5-carboxylic ester

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401120A (en) * 1965-10-23 1968-09-10 Gaf Corp Corrosion inhibitors
GB1164510A (en) * 1967-06-15 1969-09-17 Ici Ltd Novel Isoxazole Derivatives, the preparation thereof, and Compositions containing the same
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
JPS57188587A (en) * 1981-05-15 1982-11-19 Tanabe Seiyaku Co Ltd Thienyloxazolylacetic acid derivative and its preparation
JPS58183676A (ja) * 1982-04-19 1983-10-26 Takeda Chem Ind Ltd オキサゾ−ル誘導体
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents

Also Published As

Publication number Publication date
DE3682873D1 (de) 1992-01-23
EP0220573B1 (de) 1991-12-11
DK470886D0 (da) 1986-10-02
US4774253A (en) 1988-09-27
IL80290A0 (en) 1987-01-30
PT83565B (pt) 1989-05-31
PT83565A (en) 1986-11-01
DK470886A (da) 1987-04-18
IL80290A (en) 1990-11-29
NO167284C (no) 1991-10-23
EP0220573A1 (de) 1987-05-06
ES2010537A6 (es) 1989-11-16
FI864052A0 (fi) 1986-10-07
NO864128L (no) 1987-04-21
ZW19786A1 (en) 1988-05-18
PH23022A (en) 1989-03-03
MC1770A1 (fr) 1987-07-17
HUT44245A (en) 1988-02-29
SU1514245A3 (ru) 1989-10-07
NO167284B (no) 1991-07-15
AU594382B2 (en) 1990-03-08
CA1287058C (en) 1991-07-30
HU195792B (en) 1988-07-28
FI864052A7 (fi) 1987-04-18
NO864128D0 (no) 1986-10-16
AU6383886A (en) 1987-04-30
CS741586A2 (en) 1987-07-16
CS255881B2 (en) 1988-03-15
NZ217871A (en) 1990-03-27

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-10-16