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ES2002023A6 - Procedimiento para la fabricacion de derivados de 9-(tio-substituido)-4h-pirido(1,2-a)pirimidin-4-ona - Google Patents

Procedimiento para la fabricacion de derivados de 9-(tio-substituido)-4h-pirido(1,2-a)pirimidin-4-ona

Info

Publication number
ES2002023A6
ES2002023A6 ES8602449A ES8602449A ES2002023A6 ES 2002023 A6 ES2002023 A6 ES 2002023A6 ES 8602449 A ES8602449 A ES 8602449A ES 8602449 A ES8602449 A ES 8602449A ES 2002023 A6 ES2002023 A6 ES 2002023A6
Authority
ES
Spain
Prior art keywords
optionally substituted
pyrido
pyrimidin
derivatives
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602449A
Other languages
English (en)
Inventor
Shigeru Matsutani
Yukio Mizushima
Masami Doteuchi
Yasunobu Ishibara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES2002023A6 publication Critical patent/ES2002023A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA FABRICACION DE DERIVADOS DE 9-(TIO SUBSTITUIDO)-4H-PIRIDO 1,2-A PIRIMIDIN-4-ONA DE FORMULA: QUE COMPRENDE LA REACCION DEL COMPUESTO CON UN COMPUESTO ACILANTE DE FORMULA R1COX, A UNA TEMPERATURA COMPRENDIDA APROXIMADAMENTE ENTRE 0JC Y 80JC, PREFERENTEMENTE A TEMPERATURA AMBIENTE EN PRESENCIA DE UNA BASE EN UN DISOLVENTE, LA ACILACION CON EL ACIDO CARBOXILICO SE PUEDE OBTENER CONDUCIENDO LA REACCION EN PRESENCIA DE UN AGENTE DESHIDRATANTE TAL COMO DCC O SIMILAR EN UN DISOLVENTE, ADEMAS SE PUEDE REALIZAR LA ACILACION CON EL ACIDO CARBOXILICO Y CLOROCARBONATO-TRIETILAMINA ALQUILO INFERIOR EN UN DISOLVENTE ENTRE 0JC Y 100JC.
ES8602449A 1985-09-25 1986-09-25 Procedimiento para la fabricacion de derivados de 9-(tio-substituido)-4h-pirido(1,2-a)pirimidin-4-ona Expired ES2002023A6 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21318185 1985-09-25
JP1159186 1986-01-21
JP18115986 1986-07-30

Publications (1)

Publication Number Publication Date
ES2002023A6 true ES2002023A6 (es) 1988-07-01

Family

ID=27279485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602449A Expired ES2002023A6 (es) 1985-09-25 1986-09-25 Procedimiento para la fabricacion de derivados de 9-(tio-substituido)-4h-pirido(1,2-a)pirimidin-4-ona

Country Status (10)

Country Link
US (1) US4840953A (es)
EP (1) EP0218423B1 (es)
KR (1) KR930009011B1 (es)
CN (1) CN1013447B (es)
AU (1) AU588917B2 (es)
CA (1) CA1283411C (es)
DE (1) DE3670843D1 (es)
DK (1) DK169580B1 (es)
ES (1) ES2002023A6 (es)
GB (1) GB2181129B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
JP5739329B2 (ja) 2008-06-17 2015-06-24 インスティチュート・パスツール・コリアＩｎｓｔｉｔｕｔ Ｐａｓｔｅｕｒ Ｋｏｒｅａ 抗結核剤としてのピリドピリミジン化合物
WO2011031658A1 (en) * 2009-09-09 2011-03-17 E. I. Du Pont De Nemours And Company Herbicidal pyrimidone derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907798A (en) * 1966-06-15 1975-09-23 Sterling Drug Inc Preparation of 4H-pyrido{8 1,2-a{9 pyrimidin-4-ones from cyclic alkylidene 2-pyridylaminomethylenemalonates
AT294107B (de) * 1966-11-02 1971-11-10 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von neuen Homopyrimidazol-Derivaten sowie von deren Salzen
US3960847A (en) * 1972-04-17 1976-06-01 E. R. Squibb & Sons, Inc. 9-Substituted-4-oxopyrido(1,2-α)pyrimidine-3-carboxylic acids and derivatives thereof
HU168541B (es) * 1973-11-24 1976-05-28
US4022897A (en) * 1974-03-04 1977-05-10 E. R. Squibb & Sons, Inc. CNS active compounds
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
JPS5830760B2 (ja) * 1980-10-09 1983-07-01 株式会社日立製作所 プリント回路板の製法
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents

Also Published As

Publication number Publication date
EP0218423B1 (en) 1990-05-02
DK456986D0 (da) 1986-09-24
DE3670843D1 (de) 1990-06-07
CA1283411C (en) 1991-04-23
EP0218423A2 (en) 1987-04-15
AU6310486A (en) 1987-03-26
GB2181129B (en) 1989-09-20
GB2181129A (en) 1987-04-15
GB8623116D0 (en) 1986-10-29
AU588917B2 (en) 1989-09-28
CN86106902A (zh) 1987-06-10
KR870003105A (ko) 1987-04-15
KR930009011B1 (ko) 1993-09-18
DK169580B1 (da) 1994-12-12
CN1013447B (zh) 1991-08-07
EP0218423A3 (en) 1988-01-20
US4840953A (en) 1989-06-20
DK456986A (da) 1987-03-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601