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NO922812L - Naftyridin- og kinolizinderivater og farmasoeytiske preparater inneholdende disse - Google Patents

Naftyridin- og kinolizinderivater og farmasoeytiske preparater inneholdende disse

Info

Publication number
NO922812L
NO922812L NO92922812A NO922812A NO922812L NO 922812 L NO922812 L NO 922812L NO 92922812 A NO92922812 A NO 92922812A NO 922812 A NO922812 A NO 922812A NO 922812 L NO922812 L NO 922812L
Authority
NO
Norway
Prior art keywords
alkyl
compounds
pharmaceutical preparations
preparations containing
derivatives
Prior art date
Application number
NO92922812A
Other languages
English (en)
Other versions
NO922812D0 (no
Inventor
Robin D Clark
Michael Spedding
William Salisbury Redfern
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO922812D0 publication Critical patent/NO922812D0/no
Publication of NO922812L publication Critical patent/NO922812L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dekahydro-8H-isokino-[2, l-g]-[l,6]- naftyridin- og dekahydrobenzo-[a]-pyr- rolo-[2,3-e]-kinolizin-derivater med den generelle formel: hvor: X og Y er hydrogen; hydroksy; C;_6-alkyl; Cj.6-alkoksy eller halogen; eller X og Y, når disse står i nabostilling til hverandre, sammen er metylen- dioksy eller etylen-1,2-dioksy, R er C^-alkyl, cykloalkyl med 3-8 karbonatomer; fenyl eller fenyl- lavere-alkyl hvor enhver fenylgruppe eventuelt kan være substituert med en eller to substituenter valgt blant halogen, C^-alkyl og C^-al- koksy; eller -ANHSOjR1, hvor A er Cj.j-alkylen og R1 er Cj.e-alkyl eller -NR2R3, hvor R2 og R3 uavhengig av hverandre er hydrogen eller C^,t- alkyl, eller R2 og R3 sam- men er cykloalkyl med 3-8 karbonatomer; og n er l eller 2; og i farmasøytisk henseende aksepterbare salter av disse derivater. Forbindelsene er anvendelige som a2-adrenoseptorantago- nister, spesielt som a2-adrenoseptor- antagonister som virker selektivt på de perifere systemer. Fremstillingen av for- bindelsene er beskrevet og likeledes farmasøytiske preparater inneholdende forbindelsene som aktiv bestanddel.
NO92922812A 1991-07-17 1992-07-16 Naftyridin- og kinolizinderivater og farmasoeytiske preparater inneholdende disse NO922812L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73169191A 1991-07-17 1991-07-17

Publications (2)

Publication Number Publication Date
NO922812D0 NO922812D0 (no) 1992-07-16
NO922812L true NO922812L (no) 1993-01-18

Family

ID=24940584

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922812A NO922812L (no) 1991-07-17 1992-07-16 Naftyridin- og kinolizinderivater og farmasoeytiske preparater inneholdende disse

Country Status (14)

Country Link
EP (1) EP0524004A1 (no)
JP (1) JPH0665242A (no)
KR (1) KR930002346A (no)
AU (1) AU655998B2 (no)
CA (1) CA2074038A1 (no)
FI (1) FI923267A7 (no)
HU (2) HUT61550A (no)
IE (1) IE922314A1 (no)
IL (1) IL102521A (no)
IT (1) IT1256880B (no)
NO (1) NO922812L (no)
NZ (1) NZ243586A (no)
TW (1) TW209219B (no)
ZA (1) ZA925324B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004022294D1 (en) 2003-06-20 2009-09-10 Hoffmann La Roche Hexahydropyridoisochinoline als dpp-iv-inhibitoren
CN103387583B (zh) * 2012-05-09 2018-04-13 中国科学院上海药物研究所 二芳基并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791108A (en) * 1987-04-13 1988-12-13 Syntex (U.S.A.) Inc. Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers

Also Published As

Publication number Publication date
CA2074038A1 (en) 1993-01-18
NZ243586A (en) 1995-03-28
EP0524004A1 (en) 1993-01-20
HU210711A9 (en) 1995-06-28
IL102521A (en) 1996-05-14
AU2031392A (en) 1993-01-21
IE922314A1 (en) 1993-01-27
ITTO920606A1 (it) 1994-01-16
HU9202333D0 (en) 1992-10-28
AU655998B2 (en) 1995-01-19
KR930002346A (ko) 1993-02-23
FI923267L (fi) 1993-01-18
TW209219B (no) 1993-07-11
HUT61550A (en) 1993-01-28
ITTO920606A0 (it) 1992-07-16
FI923267A7 (fi) 1993-01-18
ZA925324B (en) 1994-07-17
JPH0665242A (ja) 1994-03-08
NO922812D0 (no) 1992-07-16
FI923267A0 (fi) 1992-07-16
IT1256880B (it) 1995-12-27

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