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ES2001594A6 - Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onas - Google Patents

Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onas

Info

Publication number
ES2001594A6
ES2001594A6 ES8601384A ES8601384A ES2001594A6 ES 2001594 A6 ES2001594 A6 ES 2001594A6 ES 8601384 A ES8601384 A ES 8601384A ES 8601384 A ES8601384 A ES 8601384A ES 2001594 A6 ES2001594 A6 ES 2001594A6
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
radicals
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601384A
Other languages
English (en)
Inventor
Gunther Wess
Ernold Granzer
Gerhard Beck
Hans-Hermann Lau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853530798 external-priority patent/DE3530798A1/de
Priority claimed from DE19853543336 external-priority patent/DE3543336A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2001594A6 publication Critical patent/ES2001594A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA DONDE R1 Y R 5, IGUALES O DIFERENTES, REPRESENTA HIDROGENO O RADICALES ORGANICOS SUSTITUIDOS; R2 Y R4, IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O ALQUILO SUSTITUIDO, HALOGENO O ALCOXI; Y R3 REPRESENTA HIDROGENO, ALQUILO, ALQUENILO, HALOGENO O ALCOXI, HACIENDO REACCIONAR UN FENOL DE FORMULA DONDE R1 A R5 SON COMO ANTES, CON UN YODURO QUIRAL DE FORMULA DONDE R10 SIGNIFICA UN GRUPO PROTECTOR ESTABLE FRENTE A BASES Y ACIDOS DEBILES, CON LO CUAL SE OBTIENEN ETERES DE FORMULA IV QUE SE HIDROLIZAN A SEMIACETALES CORRESPONDIENTES DE FORMULA V, LOS CUALES SE OXIDAN A LACTONAS DE FORMULA VI, QUE POR HIDROLISIS ORIGINAN LOS PRODUCTOS DE FORMULA I. LAS FORMULAS IV, V Y VI SE ILUSTRAN EN LA MEMORIA. LOS PRODUCTOS OBTENIDOS SON UTILES EN MEDICAMENTOS COMO INHIBIDORES DE LA BIOSINTESIS DE LA COLESTERINA.
ES8601384A 1985-08-29 1986-08-27 Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onas Expired ES2001594A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853530798 DE3530798A1 (de) 1985-08-29 1985-08-29 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
DE19853543336 DE3543336A1 (de) 1985-12-07 1985-12-07 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte

Publications (1)

Publication Number Publication Date
ES2001594A6 true ES2001594A6 (es) 1988-06-01

Family

ID=25835464

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601384A Expired ES2001594A6 (es) 1985-08-29 1986-08-27 Procedimiento para preparar 6-fenoximetil-4-hidroxitetrahidropiran-2-onas

Country Status (14)

Country Link
EP (1) EP0216127B1 (es)
KR (1) KR870002115A (es)
AU (1) AU6202986A (es)
DE (1) DE3674521D1 (es)
DK (1) DK409786A (es)
ES (1) ES2001594A6 (es)
FI (1) FI863470A7 (es)
GR (1) GR862208B (es)
HU (1) HUT44770A (es)
IL (1) IL79854A0 (es)
NO (1) NO863460L (es)
NZ (1) NZ217366A (es)
PH (1) PH23860A (es)
PT (1) PT83270B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722809A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag 3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte
US5166171A (en) * 1988-05-13 1992-11-24 Hoechst Aktiengesellschaft 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia
IL90249A (en) * 1988-05-13 1994-01-25 Hoechst Ag Hydroxytethrahydropyran-2-ones, the corresponding dihydroxycarboxylic acid derivatives and salts, process of preparation and pharmaceutical compositions containing them
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
FR2653119B1 (fr) * 1989-10-18 1994-08-05 Lipha Nouveaux aryloxy alcoyl benzenes, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
NO300539B1 (no) * 1992-11-30 1997-06-16 Sankyo Co alfa,omega-diarylalkanderivater, med terapeutisk aktivitet for behandling og forhindring av sirkulasjonssykdommer og psykoser, og farmasöytiske preparater inneholdende disse derivater
AU6315300A (en) * 1999-07-26 2001-02-13 Shionogi & Co., Ltd. Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5559180A (en) 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent

Also Published As

Publication number Publication date
EP0216127B1 (de) 1990-09-26
PT83270A (de) 1986-09-01
KR870002115A (ko) 1987-03-30
PH23860A (en) 1989-11-23
DE3674521D1 (de) 1990-10-31
NO863460D0 (no) 1986-08-28
NO863460L (no) 1987-03-02
PT83270B (de) 1988-10-03
EP0216127A3 (en) 1987-06-16
FI863470A0 (fi) 1986-08-27
HUT44770A (en) 1988-04-28
DK409786D0 (da) 1986-08-28
NZ217366A (en) 1989-08-29
IL79854A0 (en) 1986-11-30
GR862208B (en) 1986-12-23
AU6202986A (en) 1987-03-05
DK409786A (da) 1987-03-01
EP0216127A2 (de) 1987-04-01
FI863470A7 (fi) 1987-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980601