[go: up one dir, main page]

ES2001108A6 - Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano. - Google Patents

Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano.

Info

Publication number
ES2001108A6
ES2001108A6 ES8601227A ES8601227A ES2001108A6 ES 2001108 A6 ES2001108 A6 ES 2001108A6 ES 8601227 A ES8601227 A ES 8601227A ES 8601227 A ES8601227 A ES 8601227A ES 2001108 A6 ES2001108 A6 ES 2001108A6
Authority
ES
Spain
Prior art keywords
giving
reacts
reaction
dihalo
phalimidide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601227A
Other languages
English (en)
Inventor
Gerhart Fritz
Pierre Mamont
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES2001108A6 publication Critical patent/ES2001108A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE GEM-DIHALO-1,8-DIAMINO-4-AZA-OCTANO. COMPRENDE: 1) REACCION DE (II) CON BROMURO DE BENCILO DANDO (III), SEPARACION DE LOS ISOMEROS Y REACCION CON FTALIMIDURO POTASICO DANDO (IV) QUE REACCIONA CON HIDRAZINA SEGUIDO DE PROTECCION DANDO (V) QUE SE ALQUILA PARA DAR (VI), SEGUIDO DE REACCION CON CLORURO DE METANOSULFONILO Y CON FTALIMIDURO DE POTASIO DANDO (VII) QUE REACCIONA CON HIDRAZINA DE CALEFACCION CON HBR PARA DAR (VIII); 2) REACCION DE UN 2,2-DIHALO-1,4-BUTANODIOL CON CLORURO DE METANOSULFONILO SEGUIDO DE CALEFACCION CON DIAZABICICLOUNDECENO DANDO (IX) QUE REACCIONA CON FTALIMIDURO POTASICO SEGUIDO DE RUPTURA DANDO (X) QUE SE PROTEGE Y ALQUILA DANDO (XI) QUE SE OXIDA Y REDUCE DANDO (XII) EL CUAL REACCIONA CON CLORURO DE METANOSULFONILO Y CON FTALIMIDURO POTASIDO DANDO (XIII) QUE SE CALIENTA CON HIDRAZINA Y CON HBR DANDO (XIV). LOS COMPUESTOS (I) SON UTILES COMO AGENTES ANTIPROLIFERATIVOS O ANTITUMORALES.
ES8601227A 1985-08-21 1986-08-20 Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano. Expired ES2001108A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/767,928 US4695654A (en) 1985-08-21 1985-08-21 Gem-dihalo-1,8-diamino-4-aza-octanes

Publications (1)

Publication Number Publication Date
ES2001108A6 true ES2001108A6 (es) 1988-04-16

Family

ID=25080994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601227A Expired ES2001108A6 (es) 1985-08-21 1986-08-20 Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano.

Country Status (20)

Country Link
US (2) US4695654A (es)
EP (1) EP0215319B1 (es)
JP (1) JPH0667880B2 (es)
KR (1) KR900006132B1 (es)
CN (1) CN1012732B (es)
AR (1) AR242018A1 (es)
AT (1) ATE68471T1 (es)
AU (1) AU584730B2 (es)
CA (1) CA1265159A (es)
DE (1) DE3682007D1 (es)
DK (1) DK396886A (es)
ES (1) ES2001108A6 (es)
FI (1) FI84816C (es)
GR (1) GR862149B (es)
HU (1) HU200987B (es)
IL (1) IL79752A0 (es)
NO (1) NO164972C (es)
NZ (1) NZ217248A (es)
PT (1) PT83231B (es)
ZA (1) ZA866181B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1274547A (en) * 1985-08-21 1990-09-25 Fritz Gerhart Gem-dihalo and tetrahalo-1,12-diamino-4, 9-diaza-dodecanes
NO884565L (no) * 1987-10-15 1989-04-17 Univ Moskovsk Preparat for kontrastdannelse ved diagnose av ondartet neoplasma.
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
GB9301898D0 (en) * 1993-01-30 1993-03-17 Univ Liverpool Method for localising and measuring the profileration of cancer and compositions for same
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
CN114685325B (zh) * 2020-12-29 2024-05-28 苏州瑞博生物技术股份有限公司 一种含胺化合物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004996A (en) * 1974-12-23 1977-01-25 Merck & Co., Inc. Fluorination of organic compounds
GB2082579B (en) * 1980-08-23 1984-02-08 Merrell Toraude & Co Fluorinated diaminobutane derivatives
US4720489A (en) * 1984-10-15 1988-01-19 Douglas Shander Hair growth modification with ornithine decarboxylase inhibitors
CA1274547A (en) * 1985-08-21 1990-09-25 Fritz Gerhart Gem-dihalo and tetrahalo-1,12-diamino-4, 9-diaza-dodecanes

Also Published As

Publication number Publication date
AR242018A1 (es) 1993-02-26
HU200987B (en) 1990-09-28
KR900006132B1 (ko) 1990-08-24
NO863343D0 (no) 1986-08-20
ATE68471T1 (de) 1991-11-15
FI84816C (fi) 1992-01-27
JPH0667880B2 (ja) 1994-08-31
PT83231B (pt) 1988-07-01
NO164972C (no) 1990-12-05
FI863352A0 (fi) 1986-08-19
PT83231A (en) 1986-09-01
NO863343L (no) 1987-02-23
CA1265159C (en) 1990-01-30
EP0215319A2 (en) 1987-03-25
ZA866181B (en) 1987-04-29
EP0215319B1 (en) 1991-10-16
KR870002045A (ko) 1987-03-28
DK396886A (da) 1987-02-22
JPS6245564A (ja) 1987-02-27
US4851448A (en) 1989-07-25
EP0215319A3 (en) 1988-12-14
FI863352L (fi) 1987-02-22
FI84816B (fi) 1991-10-15
IL79752A0 (en) 1986-11-30
HUT44753A (en) 1988-04-28
CN1012732B (zh) 1991-06-05
DE3682007D1 (de) 1991-11-21
CN86105154A (zh) 1987-04-22
NZ217248A (en) 1989-05-29
DK396886D0 (da) 1986-08-20
AU584730B2 (en) 1989-06-01
AU6155886A (en) 1987-02-26
US4695654A (en) 1987-09-22
NO164972B (no) 1990-08-27
GR862149B (en) 1986-12-23
CA1265159A (en) 1990-01-30

Similar Documents

Publication Publication Date Title
ES2152936T3 (es) Compuestos benzoheterociclicos.
GB1542824A (en) Process for the hydrocyanation of unsaturated organic compounds containing at least one ethylenic double bond
ATE61591T1 (de) Zinn enthaltendes, aktiviertes silicium fuer die direktreaktion.
ATE57946T1 (de) Schlagzaehe polyamid-formmassen.
ES8801654A1 (es) Un procedimiento para preparar derivados de piridina
ES2153748A1 (es) Mezcla sinergica de estabilizadores a base de compuestos de polialquil-1-1-oxa-diaza-espirodecano.
ES2001108A6 (es) Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano.
DK208186D0 (da) P-sulfofenylalkylkarbonater samt detergentblandinger og detergentadditiver indeholdende saadanne forbindelser
GR851777B (es)
JPS57102836A (en) Manufacture of carboxylated organic compound
ES503800A0 (es) Procedimiento para la preparacion de peroxido de hidrogeno segun el procedimiento de antraquinona
DE3475781D1 (en) Oxidation of unsaturated organic compounds with hydrogen peroxide
JPS5562025A (en) Manufacture of organic fluorine compound by calcium fluoride
ES8703483A1 (es) Procedimiento de preparar mono-o-fosfatoesteres de compues- tos de catecolamina
DK65184D0 (da) Komfektioneret tekstilbloedgoeringsmiddelkoncentrat
DE2966299D1 (en) Polyolefins stabilized against light-induced degradation and a light stabilizer composition therefor
ES8401965A1 (es) Un procedimiento para la preparacion de un derivado de piridoindol.
MX9303863A (es) 2-4-dialquil-6-alquilfenoles secundarios.
TR22986A (tr) Halka hetero atomlari haiz bisiklo-heptanlar,oktanlar ve nonanlar,bunlarin hazirlanmasi ve pestibid olarak kullanimlari
RU93035828A (ru) Способ получения дизащищенного 2,3-гидроксиметилциклобутанола
ES2085303T3 (es) Procedimiento para la preparacion de terpenos.
GR852920B (es)
IT7821911A0 (it) Mescola madre a base elastomerica comprendente un elevato contenuto di cariche ausiliarie.
ES2082817T3 (es) Metodo para impedir coloraciones en acetoxisilanos de vinilo.
JPS5384923A (en) Method of dechlorizing organic chlorine compound

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100528