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ES2000879A6 - Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo - Google Patents

Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo

Info

Publication number
ES2000879A6
ES2000879A6 ES8601352A ES8601352A ES2000879A6 ES 2000879 A6 ES2000879 A6 ES 2000879A6 ES 8601352 A ES8601352 A ES 8601352A ES 8601352 A ES8601352 A ES 8601352A ES 2000879 A6 ES2000879 A6 ES 2000879A6
Authority
ES
Spain
Prior art keywords
phenylpropyl
acid salt
inorganic acid
alanylchloride
ethoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601352A
Other languages
English (en)
Inventor
Kazuhiko Yamada
Yoshifumi Yanagida
Satomi Takahashi
Takehisa Ohashi
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of ES2000879A6 publication Critical patent/ES2000879A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA PREPARAR UNA SAL DE ACIDO INORGANICO DE CLORURO DE N-1(S)-ETOXICARBONIL-3-FENILPROPIL-L-ANALILO QUE TIENE LA FORMULA (I) QUE COMPRENDE HACER REACCIONAR UNA SAL DE ACIDO INORGANICO DE N-1(S)-ETOXICARBONIL-3-FENILPROPIL-L-ANALINA CON PENTACLORURO DE FOSFORO EN UN DISOLVENTE ORGANICO INACTIVO. DE ACUERDO CON EL PRESENTE INVENTO, PUEDE PREPARARSE ECONOMICA Y FACILMENTE ACEI.
ES8601352A 1985-08-27 1986-08-26 Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo Expired ES2000879A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60188242A JPS6248655A (ja) 1985-08-27 1985-08-27 Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニルクロリド無機酸塩及びその製造法

Publications (1)

Publication Number Publication Date
ES2000879A6 true ES2000879A6 (es) 1988-03-16

Family

ID=16220273

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601352A Expired ES2000879A6 (es) 1985-08-27 1986-08-26 Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo

Country Status (7)

Country Link
US (1) US4760162A (es)
EP (1) EP0219651B1 (es)
JP (1) JPS6248655A (es)
CA (1) CA1261344A (es)
DE (1) DE3675328D1 (es)
ES (1) ES2000879A6 (es)
IE (1) IE59257B1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300362B1 (en) * 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
US20100324304A1 (en) * 2007-11-13 2010-12-23 Ben De Lange Improved ramipril synthesis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2126180A (en) * 1929-01-16 1938-08-09 Parke Davis & Co Ureido n-diaryl dicarboxylic acid halides
US2099781A (en) * 1933-10-27 1937-11-23 Du Pont Halogenation process and product
GB1241844A (en) * 1968-08-23 1971-08-04 Beecham Group Ltd Penicillins
EP0018546B1 (en) * 1979-04-25 1983-09-28 BIOCHEMIE Gesellschaft m.b.H. Process for the production of phenylglycyl chloride hydrochlorides
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4556652A (en) * 1984-03-02 1985-12-03 Usv Pharmaceutical Corp. Antihypertensive spiro-amidoamino compounds
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法

Also Published As

Publication number Publication date
EP0219651A1 (en) 1987-04-29
US4760162A (en) 1988-07-26
IE59257B1 (en) 1994-01-26
JPS6248655A (ja) 1987-03-03
JPH0333149B2 (es) 1991-05-16
DE3675328D1 (de) 1990-12-06
IE862246L (en) 1987-02-27
CA1261344A (en) 1989-09-26
EP0219651B1 (en) 1990-10-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060828