[go: up one dir, main page]

ES2075082T3 - Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular. - Google Patents

Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular.

Info

Publication number
ES2075082T3
ES2075082T3 ES90105606T ES90105606T ES2075082T3 ES 2075082 T3 ES2075082 T3 ES 2075082T3 ES 90105606 T ES90105606 T ES 90105606T ES 90105606 T ES90105606 T ES 90105606T ES 2075082 T3 ES2075082 T3 ES 2075082T3
Authority
ES
Spain
Prior art keywords
isoquinoline derivatives
glaucoma
treatment
eye hypertension
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90105606T
Other languages
English (en)
Inventor
Toyohiro Tadokoro
Kiyoshi Sato
Shigeki Hatakeyama
Shigeo Kawase
Masao Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7386689A external-priority patent/JPH02255618A/ja
Priority claimed from JP24230389A external-priority patent/JPH03106816A/ja
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Application granted granted Critical
Publication of ES2075082T3 publication Critical patent/ES2075082T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

EL USO DE DERIVADOS ISOQUINOLINE PARA EL TRATAMIENTO DE GLAUCOMA O HIPERTENSION OCULAR. LOS DERIVADOS ISOQUINOLINE SON DE FORMULA I EN DONDE R1 ES HIDROGENO O UN GRUPO ALQUIL C1-C6 Y R2 ES UN GRUPO ALQUIL C1-C6. LA ESTABILIDAD DE LOS DERIVADOS ISOQUINOLINE CUANDO SE USAN EN LA FORMA DE UNA SOLUCION ES MEJORADA POR INCORPORARLES COMPONENTES QUE TIENEN UN GRUPO HIDROXIL FENOLICO Y/O GLICOLES QUE SIRVEN COMO ESTABILIZADORES.
ES90105606T 1989-03-28 1990-03-24 Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular. Expired - Lifetime ES2075082T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7386689A JPH02255618A (ja) 1989-03-28 1989-03-28 緑内障治療剤
JP24230389A JPH03106816A (ja) 1989-09-20 1989-09-20 緑内障治療用点眼剤

Publications (1)

Publication Number Publication Date
ES2075082T3 true ES2075082T3 (es) 1995-10-01

Family

ID=26415010

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90105606T Expired - Lifetime ES2075082T3 (es) 1989-03-28 1990-03-24 Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular.

Country Status (6)

Country Link
US (1) US5061714A (es)
EP (1) EP0389995B1 (es)
CA (1) CA2013167A1 (es)
DE (1) DE69019774T2 (es)
DK (1) DK0389995T3 (es)
ES (1) ES2075082T3 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3141051B2 (ja) * 1992-10-09 2001-03-05 日清製粉株式会社 抗動脈硬化剤
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5895645A (en) * 1995-01-31 1999-04-20 Bausch & Lomb Incorporated Opthalmic solution for artificial tears
US5800807A (en) * 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
JP4500161B2 (ja) 2002-04-30 2010-07-14 クドス ファーマシューティカルズ リミテッド フタラジノン誘導体
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7220422B2 (en) * 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
US20060135609A1 (en) * 2004-10-21 2006-06-22 Duke University Ophthamological drugs
US7994186B2 (en) * 2005-04-18 2011-08-09 Kabushiki Kaisha Yakult Honsha Pharmaceutical compositions containing camptothecins
EP1910297B1 (en) 2005-07-11 2016-05-25 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
EP2526948A1 (en) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO kinase inhibitors
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
JP2010539149A (ja) 2007-09-14 2010-12-16 アストラゼネカ アクチボラグ フタラジノン誘導体
MX2010004028A (es) 2007-10-17 2010-04-30 Kudos Pharm Ltd 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona.
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
AR070221A1 (es) 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
PT2346495T (pt) 2008-10-07 2016-11-11 Astrazeneca Uk Ltd Formulação farmacêutica 514
EP3053913B1 (en) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
TWI499418B (zh) 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
CN105263494A (zh) 2013-03-15 2016-01-20 爱瑞制药公司 联合治疗
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102579582B1 (ko) 2015-11-17 2023-09-15 에어리 파마슈티컬즈, 인코포레이티드 키나아제 억제제 및 이의 중간체의 제조 방법
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2023241652A1 (zh) * 2022-06-16 2023-12-21 广州润尔眼科生物科技有限公司 一种药物组合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4129565A (en) * 1975-07-11 1978-12-12 Nisshin Flour Milling Co., Ltd. Isocarbostyril derivatives
GB1590629A (en) * 1976-09-23 1981-06-03 Cam Gears Ltd Powerassisted gear system
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
JPS57212161A (en) * 1981-06-25 1982-12-27 Nisshin Flour Milling Co Ltd Isocarbostyril derivative
JPS59116269A (ja) * 1982-12-24 1984-07-05 Nisshin Flour Milling Co Ltd イソカルボスチリル誘導体
JPS60237070A (ja) * 1984-05-08 1985-11-25 Nisshin Flour Milling Co Ltd 光学活性イソカルボスチリル誘導体の製法
JPS6355512A (ja) * 1986-08-27 1988-03-10 Hitachi Ltd 微小物質撮像装置

Also Published As

Publication number Publication date
EP0389995A2 (en) 1990-10-03
US5061714A (en) 1991-10-29
CA2013167A1 (en) 1990-09-28
EP0389995B1 (en) 1995-05-31
DE69019774D1 (de) 1995-07-06
DK0389995T3 (da) 1995-07-03
DE69019774T2 (de) 1995-11-09
EP0389995A3 (en) 1991-10-30

Similar Documents

Publication Publication Date Title
ES2075082T3 (es) Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular.
CL2021002137A1 (es) Compuestos de tioeno[3,2-b] piridin-7-amina para tratar la disautonomía familiar.
ES2083438T3 (es) Procedimiento para la preparacion de taxol utilizando una oxazinona.
ES2154262T3 (es) Uso de compuestos macrolidos para enfermedades oculares.
CO4130326A1 (es) Nuevos derivados de 2-ciano-1,3-diona, composiciones que los contienen, procedimientos para su preparacion y su uso como herbicidas
ES2061463T3 (es) Compuestos de piperidina y su preparacion y uso.
ES2082872T3 (es) Composiciones antiglaucoma que contienen 3-arilcarbonil-1-aminoalquil--1h-indol.
ES2059207T3 (es) Procedimiento para la preparacion de derivados del taxano, nuevos derivados obtenidos y composiciones farmaceuticas que les contienen.
ES2040261T3 (es) Procedimiento para preparar acidos 6-fluor-4-oxo-1,4-dihidroquinolina-3-carboxilicos sustituidos y acidos 9-fluor-3-metil-7-oxo-2,3-dihidro-7h-pirido(1,2,3-de)(1,4)benzoxazina-6-carboxilico sustituidos.
ES2097859T3 (es) Derivados de dihidropiridina, su preparacion y su utilizacion.
AR010050A1 (es) COMPUESTO TRICíCLICO SUSTITUIDO, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE Y USO PARA FABRICAR UN MEDICAMENTO PARA INHIBIR SELECTIVAMENTE SPLA2
ES2065324T3 (es) N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.
ES2009720A4 (es) Agentes para tenir los cabellos.
ES2060709T3 (es) Derivados de piridilo y pirimidilo.
ES2071479T3 (es) Derivados de indano.
ES2083972T3 (es) Arilalquil-aminas y -amidas con propiedades anticonvulsivas y neuroprotectoras.
ES2091283T3 (es) Derivados de isocromano.
ES2036560T3 (es) Un metodo para preparar una composicion sinergicamente activa para el tratamiento de hipertension.
ES2037758T3 (es) Un metodo de uso de un derivado quinolincarboxilico y su procedimiento de preparacion.
ES2062078T3 (es) Derivados 4-aminofenol y procedimientos para la preparacion de los mismos.
KR960003719A (ko) 녹내장 치료제 및 안압 강하제
DE60104435D1 (en) 2-thiocarbamoyloxy- und 2-carbamoyloxy-derivate von cyclopentyl-heptan(en)säure als therapeutische mittel
ES2042030T3 (es) Procedimiento de preparacion de una composicion para inducir y estimular el crecimiento de los cabellos y/o frenar su caida, a base de alquilpoliglicosido y de un derivado de pirimidina.
ES2124267T3 (es) Derivados macrolidas de 16 eslabones con una actividad antibacteriana prolongada en el plasma, intermediarios de sintesis y procedimiento de preparacion.
ES2052825T3 (es) Derivados de cicloalquiltiazol.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 389995

Country of ref document: ES