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ES2063578T3 - Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa. - Google Patents

Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa.

Info

Publication number
ES2063578T3
ES2063578T3 ES92903377T ES92903377T ES2063578T3 ES 2063578 T3 ES2063578 T3 ES 2063578T3 ES 92903377 T ES92903377 T ES 92903377T ES 92903377 T ES92903377 T ES 92903377T ES 2063578 T3 ES2063578 T3 ES 2063578T3
Authority
ES
Spain
Prior art keywords
arilalkilo
hydrogen
hydroxamic acid
derivatives
hydroxyurea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92903377T
Other languages
English (en)
Inventor
Rodney William Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2063578T3 publication Critical patent/ES2063578T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Lubricants (AREA)

Abstract

CIERTOS DERIVADOS NUEVOS DEL ACIDO HIDROXAMICO Y DE HIDROXIUREAS QUE TIENEN LA ESTRUCTURA (I), EN DONDE R1 ES HIDROGENO, ALKILO, ALKENILO, AMINO O AMINO SUSTITUIDO, R4 ES HIDROGENO, UN CATION FARMACEUTICAMENTE ACEPTABLE, AROILO O ALCOILO, A ES ALKILENO O ALKENILENO, X ES OXIGENO O AZUFRE, CADA Y ES HIDROGENO, HALO, CIANO, HIDROXI, ALKILO, ALCOXI, ALKILTIO, ALKENILO, ALCOXIALKILO, CICLOALKILO, ARILO, ARILOXI, ARILALKILO, ARILALKENILO, ARILALCOXI O ARILO SUSTITUIDO, Z ES OXIGENO O AZUFRE, M ES 0 O 1, N ES DE 1 A 5 Y P ES DE 2 A 6 INHIBEN LA LIPOXIGENASA DE LA ENZIMA. ESTOS COMPUESTOS, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, SON UTILES PARA EL TRATAMIENTO O ALIVIO DE ENFERMEDADES INFLAMATORIAS, ESTADOS ALERGICOS Y ENFERMEDADES CARDIOVASCULARES EN MAMIFEROS Y COMO EL INGREDIENTE ACTIVO DE COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ESTADOS DE SALUD.
ES92903377T 1991-02-07 1992-01-08 Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa. Expired - Lifetime ES2063578T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3016325A JPH0730061B2 (ja) 1991-02-07 1991-02-07 ヒドロキサム酸誘導体および組成物

Publications (1)

Publication Number Publication Date
ES2063578T3 true ES2063578T3 (es) 1995-01-01

Family

ID=11913313

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92903377T Expired - Lifetime ES2063578T3 (es) 1991-02-07 1992-01-08 Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa.

Country Status (21)

Country Link
EP (1) EP0570401B1 (es)
JP (1) JPH0730061B2 (es)
KR (1) KR930703279A (es)
AT (1) ATE113942T1 (es)
AU (1) AU648872B2 (es)
CA (1) CA2101539A1 (es)
DE (1) DE69200665T2 (es)
DK (1) DK0570401T3 (es)
ES (1) ES2063578T3 (es)
FI (1) FI933492L (es)
HU (1) HUT65539A (es)
IE (1) IE920392A1 (es)
IL (1) IL100846A0 (es)
MX (1) MX9200519A (es)
MY (1) MY134478A (es)
NO (1) NO932815L (es)
NZ (1) NZ241530A (es)
PT (1) PT100093A (es)
TW (1) TW222627B (es)
WO (1) WO1992013848A1 (es)
ZA (1) ZA92862B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5463083A (en) 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
DE69329550T2 (de) 1992-07-13 2001-05-31 Cytomed, Inc. 2,5-diaryl tetrahydro-thiopene, -furane und analoge zur behandlung von entzündungs-und immunkrankheiten
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
RU2190607C2 (ru) * 1994-06-27 2002-10-10 Миллениум Фармасьютикалз, Инк. 2,5-дизамещенные тетрагидрофураны или тетрагидротиофены, фармацевтическая композиция на их основе и способы лечения
US6201016B1 (en) * 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
MX9701042A (es) * 1996-02-07 1998-05-31 Pfizer Compuestos del acido hidroxamico.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1044308A (en) * 1964-04-28 1966-09-28 Langbein Pfanhauser Werke Ag Electrodeposition of bright copper
US3393209A (en) * 1965-10-04 1968-07-16 Dow Chemical Co Furfuryl and tetrahydrofurfuryl phenyl ureas
JPS5742632B2 (es) * 1972-12-25 1982-09-09
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
GB2201008B (en) * 1987-02-12 1991-10-23 Stc Plc Optical fibre cables

Also Published As

Publication number Publication date
IL100846A0 (en) 1992-11-15
FI933492A7 (fi) 1993-08-06
HU9302283D0 (en) 1993-10-28
DE69200665T2 (de) 1995-04-06
NO932815D0 (no) 1993-08-06
DK0570401T3 (da) 1994-12-05
DE69200665D1 (de) 1994-12-15
AU648872B2 (en) 1994-05-05
IE920392A1 (en) 1992-08-12
EP0570401A1 (en) 1993-11-24
MY134478A (en) 2007-12-31
AU1173692A (en) 1992-09-07
MX9200519A (es) 1992-08-31
JPH0730061B2 (ja) 1995-04-05
NO932815L (no) 1993-08-09
NZ241530A (en) 1994-06-27
TW222627B (es) 1994-04-21
FI933492A0 (fi) 1993-08-06
JPH04257571A (ja) 1992-09-11
KR930703279A (ko) 1993-11-29
CA2101539A1 (en) 1992-08-08
EP0570401B1 (en) 1994-11-09
ZA92862B (en) 1993-08-06
PT100093A (pt) 1993-03-31
WO1992013848A1 (en) 1992-08-20
HUT65539A (en) 1994-06-28
ATE113942T1 (de) 1994-11-15
FI933492L (fi) 1993-08-06

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