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BR9811779A - Tetrahidro prostaglandina s substituìdas por c16-c20 aromáticos úteis como agonistas fp - Google Patents

Tetrahidro prostaglandina s substituìdas por c16-c20 aromáticos úteis como agonistas fp

Info

Publication number
BR9811779A
BR9811779A BR9811779-3A BR9811779A BR9811779A BR 9811779 A BR9811779 A BR 9811779A BR 9811779 A BR9811779 A BR 9811779A BR 9811779 A BR9811779 A BR 9811779A
Authority
BR
Brazil
Prior art keywords
compounds
useful
agonists
replaced
aromatic
Prior art date
Application number
BR9811779-3A
Other languages
English (en)
Inventor
John August Wos
Mitchell Anthony Delong
Jack S Amburgey Jr
Biswanath De
Haiyan George Dai
Cynthia J Miley
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9811779A publication Critical patent/BR9811779A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"TETRAHIDRO PROSTAGLANDINAS SUBSTITUìDAS POR C~ 16~-C~ 20~ AROMáTICOS úTEIS COMO AGONISTAS FP"<D>. A invenção fornece novos análogos de PGF. Em particular, a presente invenção refere-se a compostos tendo uma estrutura de acordo com a fórmula (I) onde R~ 1~, R~ 2~, R~ 3~, R~ 4~, X, Y, e Z são definidos abaixo. Esta invenção também inclui isómeros óticos, diastereómeros e enantiómeros da referida fórmula, e os sais farmaceuticamente aceitáveis, amidas biohidrolizáveis, ésteres, e as suas imidas. Os compostos da presentes invenção são úteis para o tratamento de uma variedade de doenças e condições, tais como distúrbios ósseos e glaucoma. Portanto, a invenção ainda fornece composições farmacêuticas compreendendo estes compostos. A invenção ainda também fornece métodos de tratamento para distúrbios ósseos e glaucoma empregando estes compostos ou as composições contendo-os.
BR9811779-3A 1997-09-09 1998-09-04 Tetrahidro prostaglandina s substituìdas por c16-c20 aromáticos úteis como agonistas fp BR9811779A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5824697P 1997-09-09 1997-09-09
PCT/US1998/018340 WO1999012896A1 (en) 1997-09-09 1998-09-04 Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists

Publications (1)

Publication Number Publication Date
BR9811779A true BR9811779A (pt) 2000-09-12

Family

ID=22015602

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811779-3A BR9811779A (pt) 1997-09-09 1998-09-04 Tetrahidro prostaglandina s substituìdas por c16-c20 aromáticos úteis como agonistas fp

Country Status (23)

Country Link
US (1) US6107338A (pt)
EP (1) EP1021402B1 (pt)
JP (1) JP2001515883A (pt)
KR (1) KR20010023837A (pt)
CN (1) CN1269785A (pt)
AR (1) AR017077A1 (pt)
AT (1) ATE310721T1 (pt)
AU (1) AU741014B2 (pt)
BR (1) BR9811779A (pt)
CA (1) CA2303763C (pt)
CO (1) CO4970730A1 (pt)
DE (1) DE69832513T2 (pt)
ES (1) ES2253826T3 (pt)
HU (1) HUP0004436A3 (pt)
IL (1) IL134792A0 (pt)
NO (1) NO20001142L (pt)
NZ (1) NZ503736A (pt)
PE (1) PE123199A1 (pt)
PL (1) PL339213A1 (pt)
SK (1) SK3362000A3 (pt)
TR (1) TR200000670T2 (pt)
WO (1) WO1999012896A1 (pt)
ZA (1) ZA988231B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1114816A4 (en) * 1998-09-14 2002-09-04 Ono Pharmaceutical Co SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES- $ g (V) AND MEDICINAL PRODUCTS CONTAINING THEM AS ACTIVE INGREDIENT
NZ513825A (en) * 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
AU776375B2 (en) * 1999-08-04 2004-09-09 Duke University Novel 2-decarboxy-2-phosphinico prostaglandin F analogs
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6586462B2 (en) 2000-10-20 2003-07-01 Allergan, Inc. ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6376533B1 (en) * 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
US7631336B2 (en) 2004-07-30 2009-12-08 Broadband Itv, Inc. Method for converting, navigating and displaying video content uploaded from the internet to a digital TV video-on-demand platform
US7590997B2 (en) 2004-07-30 2009-09-15 Broadband Itv, Inc. System and method for managing, converting and displaying video content on a video-on-demand platform, including ads used for drill-down navigation and consumer-generated classified ads
US20060135609A1 (en) * 2004-10-21 2006-06-22 Duke University Ophthamological drugs
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
JP2012507552A (ja) 2008-10-29 2012-03-29 アエリエ・ファーマシューティカルズ・インコーポレーテッド プロスタグラジンのアミノ酸塩
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
ES2553827T3 (es) 2009-05-01 2015-12-14 Aerie Pharmaceuticals, Inc. Inhibidores de mecanismo doble para el tratamiento de enfermedad
US8822527B2 (en) 2011-10-17 2014-09-02 Biotheryx, Inc. Substituted biaryl alkyl amides
FI3811943T3 (fi) 2013-03-15 2023-04-14 Aerie Pharmaceuticals Inc Yhdiste käytettäväksi silmäsairauksien hoidossa
CN104140410B (zh) * 2013-05-09 2017-12-15 江苏豪森药业集团有限公司 鲁比前列酮的制备方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
EP3609871A4 (en) 2017-03-31 2021-01-06 Aerie Pharmaceuticals, Inc. ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
IL50310A (en) * 1972-11-08 1977-08-31 Pfizer Dimethyl ketophosphonates
JPS5720305B2 (pt) * 1973-02-28 1982-04-27
DE2365101A1 (de) * 1973-12-21 1975-07-10 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
DE2460990A1 (de) * 1974-12-21 1976-07-01 Hoechst Ag Neue prostaglandin-analoga und verfahren zu ihrer herstellung
DE2737808A1 (de) * 1976-08-27 1978-03-16 Pfizer 2-substituierte aryl-heterocyclische omega-pentanorprostaglandine
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
WO1998021180A1 (en) * 1995-06-07 1998-05-22 Alcon Laboratories, Inc. Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
US5741810A (en) * 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
PT857718E (pt) * 1996-06-10 2002-11-29 Sucampo Ag Antagonista da endotelina
DE69714274T3 (de) * 1996-09-17 2006-06-01 Asahi Glass Co., Ltd. Fluorierte prostaglandinderivate und medikamente
AU5258698A (en) * 1996-11-12 1998-06-03 Alcon Laboratories, Inc. 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension
WO1998020880A2 (en) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
CA2293325C (en) * 1997-05-09 2008-09-02 The Mount Sinai School Of Medicine Of The City University Of New York 8-iso-prostaglandins for glaucoma therapy

Also Published As

Publication number Publication date
AR017077A1 (es) 2001-08-22
AU741014B2 (en) 2001-11-22
NO20001142D0 (no) 2000-03-06
CA2303763A1 (en) 1999-03-18
EP1021402B1 (en) 2005-11-23
DE69832513T2 (de) 2006-07-13
NZ503736A (en) 2002-06-28
JP2001515883A (ja) 2001-09-25
CA2303763C (en) 2007-04-24
EP1021402A1 (en) 2000-07-26
ZA988231B (en) 1999-03-09
CO4970730A1 (es) 2000-11-07
WO1999012896A1 (en) 1999-03-18
PL339213A1 (en) 2000-12-04
US6107338A (en) 2000-08-22
IL134792A0 (en) 2001-04-30
HUP0004436A2 (hu) 2001-05-28
ATE310721T1 (de) 2005-12-15
ES2253826T3 (es) 2006-06-01
KR20010023837A (ko) 2001-03-26
HUP0004436A3 (en) 2001-09-28
TR200000670T2 (tr) 2000-11-21
NO20001142L (no) 2000-05-04
AU9219498A (en) 1999-03-29
PE123199A1 (es) 2000-02-02
CN1269785A (zh) 2000-10-11
DE69832513D1 (de) 2005-12-29
SK3362000A3 (en) 2000-10-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007.