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EP2754615B1 - System for personalised filling of blister packs with medications according to specified prescription data - Google Patents

System for personalised filling of blister packs with medications according to specified prescription data Download PDF

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Publication number
EP2754615B1
EP2754615B1 EP13151166.9A EP13151166A EP2754615B1 EP 2754615 B1 EP2754615 B1 EP 2754615B1 EP 13151166 A EP13151166 A EP 13151166A EP 2754615 B1 EP2754615 B1 EP 2754615B1
Authority
EP
European Patent Office
Prior art keywords
medicament
metering
blister
compartments
magazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP13151166.9A
Other languages
German (de)
French (fr)
Other versions
EP2754615A1 (en
Inventor
Edwin Kohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP13151166.9A priority Critical patent/EP2754615B1/en
Priority to PCT/EP2014/050151 priority patent/WO2014108402A1/en
Priority to CA2897748A priority patent/CA2897748A1/en
Priority to CN201480004827.8A priority patent/CN104918856B/en
Priority to US14/760,593 priority patent/US20150353213A1/en
Publication of EP2754615A1 publication Critical patent/EP2754615A1/en
Application granted granted Critical
Publication of EP2754615B1 publication Critical patent/EP2754615B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/005—Unpacking of articles or materials, not otherwise provided for by expelling contents, e.g. by squeezing the container
    • B65B69/0058—Solid contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged
    • B65B57/14—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B65B61/20—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for adding cards, coupons or other inserts to package contents
    • B65B61/202—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for adding cards, coupons or other inserts to package contents for attaching articles to the outside of a container

Definitions

  • the invention relates to a system for personal placement of Be Schollblistern with drugs according to predetermined prescription data, the Be Schollblister in a matrix configuration in rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week, arranged receiving compartments for respective drug administration units exhibit.
  • From the DE 10 2004 034 024 A2 is an individual blister pack for the weekly drug needs of a patient (weekly blister) known to take the medication in a order by date, day of the week and time of day (morning, noon and evening and / or night) ordered.
  • the receiving compartments of the blister pack for receiving the respective medicaments are arranged in matrix form and with seven daily columns, each with at least three time of day compartments, which are closed overall by a continuous blister foil.
  • Affixed to the blister pack is a carton-shaped lid, on which the patient-specific the composition of the individual time of day subjects as well as prescription information concerning the respective medicaments is contained.
  • Such weekly blister packs are for patients who regularly need to take several different drugs, a help not only to remember the intake of important medications and on the other hand to keep a reliable overview of what medications are already taken to avoid a potentially harmful over-medication ,
  • WO 2005 102 841 A1 is a system for equipping such patient-specific blister packs with the desired drug composition known.
  • a dispensing station For each drug, a dispensing station is provided which conveys the medicaments from a temporary package in the form of a strip blister into the corresponding receiving compartments of the packaging unit by spatulas associated with the receiving compartments of the blister pack. All patient-specific blister packs cyclically pass through all the dispensing stations of the system, whereby only at those stations medications are taken which correspond to the prescription data associated with the individual blister pack. In this way, patient-specific packaging units can be filled automatically and safely with a selection of several hundred drugs.
  • WO 2009/023632 is a system for person-specific placement of drug packages known, which pass through a plurality of filling stations for each drug, in which filling the medication from a reservoir initially transferred to a movable transfer slide and then filled into the drug packages.
  • the object is achieved by a system for personal placement of Be Schollblistern with drugs according to prescribed prescription data, the Be Stirllblister in a matrix configuration in rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week, arranged receiving compartments for respective drugs
  • Administering units comprising a plurality of successively arranged drug filling stations for loading the Be Stirllblister each with a particular drug, and a transport device configured to transport the Be colllblister individually in a row in a direction of movement along the drug filling stations each drug filling station movable between two positions Vordosiermagazin with several Vordosierfumbleern has, which is adapted to the drug in a first position in a or to receive in a second position, the drug from the Vordosierfownern in corresponding receiving compartments of the Be colllblisters, characterized in that in each drug filling station (40) the drug by means of a strip blister (45) supplied, and each
  • each drug filling station the medicament is delivered by means of a strip blister, each medicament filling station having one or more ejector plungers for expelling the drug from blister stations of the strip blister into the pre-metering compartments of the pre-metering magazine.
  • each medicament filling station having one or more ejector plungers for expelling the drug from blister stations of the strip blister into the pre-metering compartments of the pre-metering magazine.
  • the pre-metering preferably has a in the second position of the same displaceable in the transverse direction bottom, which ensures a fast and safe transfer of medication into the receiving compartments of the Be colllblisters.
  • the pre-metering compartments of the pre-metering magazine are preferably designed in a row such that they are arranged in the second position in each case over the receiving compartments of the filling blister arranged in a row corresponding to a number of (week) days.
  • Each medication filling station preferably has at least one sensor device for checking the correct intake of the medicament into the pre-metering compartments of the pre-metering magazine and / or the correct delivery of the medicament into the receiving compartments of the filling blister.
  • the pre-metering magazine in the region of the rest position of a drug in the Vordosierfumbleern have laterally arranged slots, wherein a first sensor device is designed to detect optically through the slots a drug in the Vordosierfumbleern during a movement of the pre-metering magazine from the first to the second position and vice versa ,
  • the bottom of the pre-metering compartments of the pre-metering magazine can be translucent or light-reflecting, and a second sensor device can comprise a camera for detecting medicaments located on the bottom of the predispersing compartments.
  • filling errors can be reliably, reliably and quickly detected, and incorrectly filled filling blisters can then be reliably sorted out in a separate method step.
  • the pre-metering magazine may have a replaceable plastic inner lining for cleaning purposes.
  • the Be Schollblister are driven by a magnetic path with a linear motor, whereby an individual control and reliable transport of a variety of Be colllblistern is possible.
  • workpiece carriers guided in a magnetic rail are provided for receiving the filling blister, which workpiece carriers are conveyed in a closed circuit, wherein the Be colllblister be placed on the workpiece carrier before assembly and removed again after the assembly process.
  • the system according to the invention may further comprise a camera arranged above the transport device for optically checking the correct placement of the filling blister in accordance with the prescription data.
  • the pre-metering magazine can be freely accessible for manual delivery of a drug. As a result, drugs that are rarely needed can be delivered manually or with other delivery techniques without sacrificing system performance.
  • the method according to the invention preferably has the method step of creating and attaching a documentation carrier to the filling blister comprising personal information and / or application information to the medicaments packed in the filling blister.
  • FIG. 1 shows in a schematic plan view of a filling module 41 of an embodiment of the inventive system for personal placement of Be Schollblistern 25.
  • Be Schollmodul 41 consists in the illustrated embodiment of five consecutively arranged drug filling stations 40, which are each provided for dispensing of dosage units of a particular type of drug.
  • the number of summarized in a Be Shellmodul 41 medication filling stations 40 is of course not limited to five, but can be selected depending on space or convenience.
  • the total number of drug filling modules 41 of the plant is not limited to a certain number. In principle, the total number of filling stations 40 determines the maximum number of medicaments that can be blistered with the system, and more than one filling station can be provided for particularly frequently used medicaments.
  • FIG. 2a shows an embodiment of a Be Schollblisters 25 for use with the inventive plant in perspective view and the FIGS. 2b and 2c in cross-sectional view with or without blister foil 27.
  • the Be Schollblister 25 arranged in matrix configuration receptacles 26, which are arranged in the illustrated embodiment in four lines corresponding to a number of intake times during a day (morning, noon, evening, night) and seven columns corresponding to the days of a week.
  • the invention is not limited to this particular arrangement of the receiving compartments 26 of the Be colllblisters.
  • FIG. 1 shows this designed as a magnetic rail guide rail 11 for transporting the Be Schollblister 25, the case on a workpiece carrier 20 (shown schematically in FIG FIG. 6 ) rest.
  • the workpiece carrier 20 is preferably provided with depressions (not shown) corresponding to the arrangement of the receiving compartments 26 of the filling blister 25.
  • a Be Valllblister 25 stops at three to seven filling stations, where the respective drug by means of a pre-metering magazine 50 is supplied in rows, as with reference to the FIGS. 3 to 6 will be explained in detail later.
  • a clean room area is planned, which in FIG. 1 schematically designated 30.
  • germ-free and particle-poor air is blown down from the ceiling in this clean room area 30, which prevents germs or undesired dust particles from entering the opened filling blister 25.
  • a phototunnel 32 with a (not shown) camera is provided, which creates an optical image of the Be colllblisters 25 after passing through the previous Be Colllmoduls 41.
  • an evaluation electronics system can check whether the drug equipment was correctly executed in accordance with the respective patient prescription data.
  • FIG. 4 illustrated schematically in plan and FIG. 6 In a cross-sectional view of the drug filling process at a drug filling station 40.
  • the filling module 25 by means of the workpiece carrier 20 to the provided Drug filling module 40 transported.
  • the Be Glallmodul 20 stops its movement and the pre-metering magazine 50 performs a movement perpendicular to the direction of movement of the Be colllblister, as in the Figures 6a and 6b indicated by an arrow.
  • At the end of this transverse movement is in each case a predispensing compartment 51 over a weekday compartment 26 of a line of the Be colllblisters 25 (FIG. FIG. 3a and FIG. 6c ).
  • an opening mechanism of the pre-metering pockets 51 of the pre-metering magazine 50 is activated, so that the medicaments located in the pre-metering compartments 51 drop into the corresponding compartments 26 of the filling blister 25 at a low drop height.
  • the opening mechanism of the pre-metering magazine is formed in the illustrated embodiment of the invention as a displaceable bottom 55 of the pre-metering magazine.
  • other mechanisms such as folding mechanisms or the like are also possible within the scope of the invention.
  • the filling blister 25 is transported further in the corresponding number of lines and the pre-metering magazine 50 moves backward (FIG. 3d figure and FIG. 6d ), is provided with a new portioning of the drugs, which are then filled in the same manner in the other time line of the Be colllblisters 25.
  • the Be Colllblister 25 moves to the next scheduled drug filling station 40th
  • FIG. 4 An embodiment of a pre-metering magazine 50 is shown in schematic perspective view in FIG FIG. 4 shown.
  • the predosing compartments 51 are in the form of a transparent plastic inner lining, which can be exchanged for cleaning purposes and can be fastened to a stable frame part 54, which is preferably made of metal.
  • Slots 52 are provided on both sides in the lower region of the side walls of the predatory bins 51 for optically checking whether a medicament is or not present in the respective predosing bins.
  • the mechanism for delivering the medication 28 into the pre-metering magazine 50 of a drug delivery station 40 is shown schematically in FIG FIG. 5 shown.
  • the medicament is supplied by means of an endless strip blister 45 which has equidistantly arranged blister stalls 46 for receiving the medicament dosages, wherein the spacing of the individual blister stalls 46 of the strip blister 45 from one another can correspond to the distance of the predispersing compartments 51 of the predosing magazines 50.
  • the strip blister 45 located in the respective medication filling stations 40 is preferably unrolled from a roll known per se with the aid of a drive mechanism (not shown).
  • a strip blister 45 is used up, then a new, filled strip blister roll can be hung without difficulty in the medication filling station 40 and / or the new strip blister can be glued or adhered directly to the existing strip blister, so that an uninterrupted supply of medicaments is ensured.
  • at least one medication filling station 40 for manual filling of the pre-metering magazine 50 may be provided. This makes it possible to increase the flexibility of the plant and to include very rarely prescribed drugs on economic conditions in the blistering.
  • Each medication filling station 40 has ejector plungers 42 for ejecting medicaments 28 from strip blister 45 into pre-metering magazine 50.
  • ejection plungers 42 are provided in a number corresponding to the number of predosounders 51 of predosing magazine 50 for time-saving parallel ejection of the medicament units; However, this is not absolutely necessary, but a sequential ejection of the drugs is also possible.
  • a medication filling station 40 has at least two sensor devices 47, 48 for checking the correct transfer of medication to the blister pre-metering magazine filling blister.
  • a first transmitted light camera or Photocell 47 detects, by means of the slits 52 provided on the predispersing compartments 51, whether there is a medicament in the corresponding predosing compartment 51 during the extension movement of the predosing magazine 50 and if it no longer lies therein during the later retracting movement, whereby the correct dispensing of the medicament units into the predispersing compartment corresponding compartments of the Be colllblisters can be validated.
  • an incident-light camera 48 is preferably provided, which also optically validates the filling state of the predosing compartments 51 before the medicament is transferred to the filling blister and then either by means of light reflection or as a transmitted-light detector.
  • the bottom of the pre-metering magazine 50 must be translucent.
  • the use of the pre-metering magazine 50 in the placement system according to the invention ensures that the ejection process from the strip blister 45 and the loading process of the Behellblisters 25 are decoupled from each other.
  • the time-critical filling process of the filling blister 25 with respect to speed can be optimized for the performance of the overall system, while more time is available for the mechanically difficult ejection process from the strip blister 45 without impairing the performance of the overall system.
  • a magnetic rail system 10 is provided with linear motor drive, which allows each workpiece carrier 20 and thus the Be Glallblister 25 located thereon to control individually.
  • the magnetic track system 10 has a self-contained guide rail 11, which in cross-sectional view in FIG. 6 is shown.
  • Each workpiece carrier 20 has a guide element 12, which surrounds the guide rail 11 and is guided in a known manner according to the principle of a magnetic levitation train contactless or touching (sliding, rolling) in the guide rail 11.
  • An electric linear motor which is also known per se, provides the individually controllable drive of the workpiece carriers 20 and thus the filling blister 25.
  • a Be Schollblister-supporting station 60 is provided which in FIG. 8 is indicated schematically.
  • a Be Schollblister removal station 61 is arranged accordingly.
  • a first method step S2 ( FIG. 7 ) an empty Be colllblister 25 is thus placed on the workpiece carrier 20 in the Be Schollblister-Avemlagestation 60.
  • the filling stations to be approached are determined in method step S4, in which in FIG. 8 shown embodiment, these are the stations A, B and C.
  • For the considered Be Shellblister 25 is now checked in step S6, whether the transport path to the next to be approached filling station is occupied by a at an intermediate filling station in a filling process involved Be clergyden Be spallblister or not. If this is the case, then the considered Be colllblister 25 follows or the previous Be Glallblister according to step S8.
  • step S10 the filling blister 25 moves according to step S10 at maximum transport speed to this next medication filling station 40, where the filling operation is carried out in method step S12.
  • the method steps S6 to S12 are repeated until it is determined in step S14 that the last intended filling station has been reached.
  • step S16 the Behellblister is removed from the Be Glallblister-removal station 61, the Behellblister 25 sealed with the blister 27 and printed (not shown) information card with patient identification information and prescription information for the patient and this information card attached to the blister. Finally, the filled and information card-filled blister 25 is ready for shipment (step S20).
  • FIG. 8 shows schematically the different states of motion of the Be colllblister.
  • Movement state (1) illustrated by a hatched rectangle with arrow, denotes a movement with maximum speed to the next drug filling station to be controlled or to a "queue" of preceding Be Shellblister
  • movement state (2) illustrated by a filled rectangle, indicates a filling a drug delivery station 40
  • motion state (3) illustrated by a hatched rectangle with no arrow
  • motion state (4) illustrated by a canted rectangle, indicates the return movement an empty workpiece carrier 20 to the Be Glallblister-Avemlagestation 60.
  • the invention allows for the time-critical process of filling the Be Glallblisters 25 from the mechanically difficult process of ejecting the medicament units from the Stsammlungblister 45 by the use of the between the strip blister 45 and the Be Schollblister 25 intermediate predosing 50, and thus the performance and reliability of the blistering process significantly increase. Furthermore, the possibility of manual filling of the pre-metering magazine allows the verbally meaningful extension of the blistering even on very rarely prescribed drugs.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Basic Packing Technique (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)

Description

Gebiet der ErfindungField of the invention

Die Erfindung betrifft eine Anlage zur personenindividuellen Bestückung von Befüllblistern mit Medikamenten entsprechend vorgegebenen Verschreibungsdaten, wobei die Befüllblister in einer Matrixkonfiguration in Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages und Spalten entsprechend einer Anzahl von Tagen, beispielsweise Wochentagen, angeordnete Aufnahmefächer für jeweilige Medikamenten-Verabreichungseinheiten aufweisen.The invention relates to a system for personal placement of Befüllblistern with drugs according to predetermined prescription data, the Befüllblister in a matrix configuration in rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week, arranged receiving compartments for respective drug administration units exhibit.

Verwandter Stand der TechnikRelated prior art

Aus der DE 10 2004 034 024 A2 ist eine individuelle Blisterpackung für den wöchentlichen Medikamentenbedarf eines Patienten (Wochenblister) bekannt, der die Medikamente in einer nach Datum, Wochentag und Tageszeit (Morgen, Mittag und Abend und/oder Nacht) geordneten Folge einnehmen soll. Die Aufnahmefächer der Blisterpackung zur Aufnahme der jeweiligen Medikamente sind in Matrixform angeordnet und mit sieben Tagesspalten mit jeweils mindestens drei Tageszeit-Fächern, die insgesamt durch eine zusammenhängende Blisterfolie verschlossen sind. An der Blisterpackung angebracht ist ein kartonförmiger Deckel, auf dem patientenindividuell die Zusammensetzung der einzelnen Tageszeit-Fächer sowie Verschreibungsinformationen betreffend die jeweiligen Medikamente enthalten ist.From the DE 10 2004 034 024 A2 is an individual blister pack for the weekly drug needs of a patient (weekly blister) known to take the medication in a order by date, day of the week and time of day (morning, noon and evening and / or night) ordered. The receiving compartments of the blister pack for receiving the respective medicaments are arranged in matrix form and with seven daily columns, each with at least three time of day compartments, which are closed overall by a continuous blister foil. Affixed to the blister pack is a carton-shaped lid, on which the patient-specific the composition of the individual time of day subjects as well as prescription information concerning the respective medicaments is contained.

Derartige Wochenblister sind für Patienten, die regelmäßig mehrere verschiedene Medikamente einnehmen müssen, eine Hilfe dafür, einerseits das Einnehmen wichtiger Medikamente nicht zu vergessen und andererseits auch einen zuverlässigen Überblick darüber zu behalten, welche Medikamente schon eingenommen sind, um eine unter Umständen schädliche Übermedikation zu vermeiden.Such weekly blister packs are for patients who regularly need to take several different drugs, a help not only to remember the intake of important medications and on the other hand to keep a reliable overview of what medications are already taken to avoid a potentially harmful over-medication ,

Aus der WO 2005 102 841 A1 ist eine Anlage zur Bestückung von derartigen patientenindividuellen Blisterpackungen mit der gewünschten Medikamentenzusammenstellung bekannt. Für jedes Medikament ist eine Ausgabestation vorgesehen, die mittels den Aufnahmefächern der Blisterpackung räumlich zugeordneten Stösseln die jeweiligen Medikamente aus einer vorübergehenden Verpackung in Form eines Streifenblisters in die entsprechenden Aufnahmefächer der Verpackungseinheit befördert. Alle patientenindividuellen Blisterpackungen durchlaufen taktweise alle Ausgabestationen der Anlage, wobei nur an denjenigen Stationen Medikamente aufgenommen werden, die den der individuellen Blisterpackung zugeordneten Verschreibungsdaten entsprechen. So können patientenindividuelle Verpackungseinheiten mit einer Auswahl aus mehreren hundert Medikamenten vollautomatisch sicher und zuverlässig befüllt werden.From the WO 2005 102 841 A1 is a system for equipping such patient-specific blister packs with the desired drug composition known. For each drug, a dispensing station is provided which conveys the medicaments from a temporary package in the form of a strip blister into the corresponding receiving compartments of the packaging unit by spatulas associated with the receiving compartments of the blister pack. All patient-specific blister packs cyclically pass through all the dispensing stations of the system, whereby only at those stations medications are taken which correspond to the prescription data associated with the individual blister pack. In this way, patient-specific packaging units can be filled automatically and safely with a selection of several hundred drugs.

Da die von der Verpackungsanlage verarbeiteten Medikamente in sehr unterschiedliche Mengen verschrieben werden, können bei den seltener verschriebenen Medikamenten relativ lange "Standzeiten" in den vorübergehenden Verpackungen, d.h. den Streifenblistern auftreten. Damit die Medikamente nicht durch das Eindringen von Feuchtigkeit oder dgl. unbrauchbar werden, muß der Streifenblister daher eine gute Versiegelung des Aufnahmeraumes für das Medikament insbesondere gegenüber Wasserdampf aufweisen. Diese hat andererseits den Nachteil, dass sie bei Anwendung einer mechanischen Kraft auf die Medikamenteneinheit durch den Stössel nicht zuverlässig an der richtigen Stelle oder nicht vollständig aufreißt, so dass es zu Fehlern bei der Bestückung der Blisterpackung kommen kann. Da schon die falsche Befüllung eines Faches zwingend die Aussortierung der gesamten Blisterpackung bedingt, sind Fehler bei der "Umpackung" der Medikamente aus dem Streifenblister in die Blisterpackung mit hohem Aufwand und Kosten verbunden. Weiterhin ist nachteilig, dass die Wartung einer Medikamenten-Befüllstation aufgrund des Taktbetriebes zum Stillstand der ganzen Anlage führt.Since the drugs processed by the packaging equipment are prescribed in very different amounts, the less frequently prescribed drugs can have relatively long "lives" in the temporary packaging, i. the strip blisters occur. Thus, the drugs are not unusable by the ingress of moisture or the like., The Strip Blister must therefore have a good seal of the receiving space for the drug especially against water vapor. On the other hand, this has the disadvantage that when a mechanical force is applied to the medicament unit by the plunger, it does not reliably rupture at the correct point or completely, so that errors can occur during the assembly of the blister pack. Since the wrong filling of a compartment necessarily requires the sorting out of the entire blister pack, errors in the "repackaging" of the medicaments from the blister strip into the blister pack are associated with great expense and expense. Another disadvantage is that the maintenance of a medication filling station due to the clock mode leads to a standstill of the entire system.

Aus der WO 2009/023632 ist eine Anlage zur personenindividuellen Bestückung von Medikamentenverpackungen bekannt, welche eine Mehrzahl von Befüllstationen für jeweils ein Medikament durchlaufen, in welchen Befüllstationen die Medikamente aus einem Vorratsbehälter zunächst in einen bewegbaren Transferschlitten übergeben und dann in die Medikamentenverpackungen gefüllt werden.From the WO 2009/023632 is a system for person-specific placement of drug packages known, which pass through a plurality of filling stations for each drug, in which filling the medication from a reservoir initially transferred to a movable transfer slide and then filled into the drug packages.

Zusammenfassung der ErfindungSummary of the invention

Es ist daher eine Aufgabe der Erfindung, eine Anlage zur personenindividuellen Bestückung von Befüllblistern mit Medikamenten entsprechend vorgegebenen Verschreibungsdaten vorzuschlagen, die eine verbesserte Leistungsfähigkeit und Zuverlässigkeit aufweist.It is therefore an object of the invention to propose a system for personal placement of Befüllblistern with drugs according to predetermined prescription data, which has improved performance and reliability.

Gelöst wird die Aufgabe durch eine Anlage zur personenindividuellen Bestückung von Befüllblistern mit Medikamenten entsprechend vorgegebenen Verschreibungsdaten, wobei die Befüllblister in einer Matrixkonfiguration in Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages und Spalten entsprechend einer Anzahl von Tagen, beispielsweise Wochentagen, angeordnete Aufnahmefächer für jeweilige Medikamenten-Verabreichungseinheiten aufweisen, umfassend eine Vielzahl hintereinander angeordneter Medikamenten-Befüllstationen zur Bestückung der Befüllblister mit jeweils einem bestimmten Medikament, und eine Transportvorrichtung ausgebildet zum Transport der Befüllblister einzeln hintereinander in einer Bewegungsrichtung entlang der Medikamenten-Befüllstationen wobei jede Medikamenten-Befüllstation ein zwischen zwei Positionen bewegbares Vordosiermagazin mit mehreren Vordosierfächern aufweist, das dazu eingerichtet ist, in einer ersten Position das Medikament in einem oder mehreren der Vordosierfächer aufzunehmen und in einer zweiten Position das Medikament aus den Vordosierfächern in entsprechende Aufnahmefächer des Befüllblisters abzugeben, dadurch gekennzeichnet, dass in jeder Medikamenten-Befüllstation (40) das Medikament mittels eines Streifenblisters (45) zugeführt, wird und jede Medikamenten-Befüllstation (40) einen oder mehrere Auswurfstössel (42) zum Ausstoßen des Medikaments aus Blisterhöfen (46) des Streifenblisters (45) in die Vordosierfächer (51) des Vordosiermagazins (50) aufweist,
im Übergabebereich der Medikamente in die Befüllblister (25) ein Reinraumbereich (30) vorgesehen ist, und
die Befüllblister (25) nach Befüllung mit Blisterfolie (27) versiegelt werden.The object is achieved by a system for personal placement of Befüllblistern with drugs according to prescribed prescription data, the Befüllblister in a matrix configuration in rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week, arranged receiving compartments for respective drugs Administering units comprising a plurality of successively arranged drug filling stations for loading the Befüllblister each with a particular drug, and a transport device configured to transport the Befüllblister individually in a row in a direction of movement along the drug filling stations each drug filling station movable between two positions Vordosiermagazin with several Vordosierfächern has, which is adapted to the drug in a first position in a or to receive in a second position, the drug from the Vordosierfächern in corresponding receiving compartments of the Befüllblisters, characterized in that in each drug filling station (40) the drug by means of a strip blister (45) supplied, and each drug filling station (40) having one or more ejector plungers (42) for expelling the medicament from blistering stations (46) of the strip blister (45) into the predispersing compartments (51) of the predosing magazine (50),
in the transfer area of the medication in the Befüllblister (25) a clean room area (30) is provided, and
the Befüllblister (25) after filling with blister foil (27) are sealed.

Durch die Verwendung des zwischen einer Aufnahmeposition und einer Abgabeposition bewegbaren Vordosiermagazins zur Befüllung der Befüllblister wird der zeitkritische Vorgang der Befüllung des Befüllblisters von dem mechanisch schwierigen Vorgang des Ausstossens der Medikamenteinheiten aus dem Streifenblister entkoppelt und somit die Leistungsfähigkeit und Zuverlässigkeit der Anlage erhöht.By the use of the movable between a receiving position and a dispensing position Vordosiermagazins for filling the Befüllblister the time-critical process of filling the Befüllblisters of the mechanical difficult process of ejecting the drug units from the strip blister decoupled and thus increases the performance and reliability of the system.

Vorzugsweise wird in jeder Medikamenten-Befüllstation das Medikament mittels eines Streifenblisters zugeführt, wobei jede Medikamenten-Befüllstation einen oder mehrere Auswurfstössel zum Ausstossen des Medikaments aus Blisterhöfen des Streifenblisters in die Vordosierfächer des Vordosiermagazins aufweist. Zur Erhöhung der Funktionssicherheit sind die Streifenblister vozugsweise nur in einer Richtung bewegbar.Preferably, in each drug filling station, the medicament is delivered by means of a strip blister, each medicament filling station having one or more ejector plungers for expelling the drug from blister stations of the strip blister into the pre-metering compartments of the pre-metering magazine. To increase the reliability of the strip blister vozugsweise only movable in one direction.

Zur Abgabe des Medikaments in die Aufnahmefächer des Befüllblisters weist das Vordosiermagazin vorzugsweise einen in der zweiten Position desselben in Querrichtung verschiebbaren Boden auf, der eine schnelle und sichere Medikamentenübergabe in die Aufnahmefächer des Befüllblisters gewährleistet.To deliver the drug into the receiving compartments of the Befüllblisters the pre-metering preferably has a in the second position of the same displaceable in the transverse direction bottom, which ensures a fast and safe transfer of medication into the receiving compartments of the Befüllblisters.

Die Vordosierfächer des Vordosiermagazins sind dabei vorzugsweise in einer Reihe derart ausgebildet, dass sie in der zweiten Position jeweils über den in einer Zeile entsprechend einer Anzahl (Wochen-)Tagen angeordneten Aufnahmefächern des Befüllblisters angeordnet sind. Durch die gleichzeitige Medikamentenübergabe in beispielsweise sieben Tagesfächer des Befüllblisters kann so Zeit eingespart werden.The pre-metering compartments of the pre-metering magazine are preferably designed in a row such that they are arranged in the second position in each case over the receiving compartments of the filling blister arranged in a row corresponding to a number of (week) days. By the simultaneous transfer of medication in, for example, seven day compartments of the Befüllblisters so time can be saved.

Jede Medikamenten-Befüllstation weist dabei vorzugsweise wenigstens eine Sensorvorrichtung zur Überprüfung der korrekten Aufnahme des Medikaments in die Vordosierfächer des Vordosiermagazins und/oder der korrekten Abgabe des Medikaments in die Aufnahmefächer des Befüllblisters auf.Each medication filling station preferably has at least one sensor device for checking the correct intake of the medicament into the pre-metering compartments of the pre-metering magazine and / or the correct delivery of the medicament into the receiving compartments of the filling blister.

Dabei kann das Vordosiermagazin im Bereich der Ruhelage eines Medikaments in den Vordosierfächern seitlich angeordnete Schlitze aufweisen, wobei eine erste Sensoreinrichtung ausgebildet ist, durch die Schlitze ein Medikament in den Vordosierfächern während einer Bewegung des Vordosiermagazins von der ersten in die zweite Position und umgekehrt optisch zu detektieren.In this case, the pre-metering magazine in the region of the rest position of a drug in the Vordosierfächern have laterally arranged slots, wherein a first sensor device is designed to detect optically through the slots a drug in the Vordosierfächern during a movement of the pre-metering magazine from the first to the second position and vice versa ,

Der Boden der Vordosierfächer des Vordosiermagazins kann lichtdurchlässig oder lichtreflektierend sein und eine zweite Sensorvorrichtung eine Kamera zur Erfassung von auf dem Boden der Vordosierfächer befindlichen Medikamenten umfassen.The bottom of the pre-metering compartments of the pre-metering magazine can be translucent or light-reflecting, and a second sensor device can comprise a camera for detecting medicaments located on the bottom of the predispersing compartments.

Durch die Sensorvorrichtungen können Befüllfehler sicher, zuverlässig und schnell detektiert und fehlerhaft bestückte Befüllblister dann in einem separaten Verfahrensschritt zuverlässig aussortiert werden.By means of the sensor devices, filling errors can be reliably, reliably and quickly detected, and incorrectly filled filling blisters can then be reliably sorted out in a separate method step.

Das Vordosiermagazin kann zur Reinigungszwecken eine austauschbare Innenverkleidung aus Kunststoff aufweisen.The pre-metering magazine may have a replaceable plastic inner lining for cleaning purposes.

Vorzugsweise werden die Befüllblister mittels einer Magnetbahn mit Linearmotor angetrieben, wodurch eine individuelle Ansteuerung und ein zuverlässiger Transport einer Vielzahl von Befüllblistern möglich ist. Vorzugsweise sind dabei in einer Magnetschiene geführte Werkstückträger zur Aufnahme der Befüllblister vorgesehen, welche Werkstückträger in einem geschlossenen Kreislauf gefördert werden, wobei die Befüllblister vor der Bestückung auf die Werkstückträger aufgesetzt und nach dem Bestückungsvorgang wieder entnommen werden.Preferably, the Befüllblister are driven by a magnetic path with a linear motor, whereby an individual control and reliable transport of a variety of Befüllblistern is possible. Preferably, workpiece carriers guided in a magnetic rail are provided for receiving the filling blister, which workpiece carriers are conveyed in a closed circuit, wherein the Befüllblister be placed on the workpiece carrier before assembly and removed again after the assembly process.

Die erfindungsgemäße Anlage kann ferner eine über der Transportvorrichtung angeordnete Kamera zur optischen Überprüfung der korrekten Bestückung der Befüllblister entsprechend den Verschreibungsdaten aufweisen.The system according to the invention may further comprise a camera arranged above the transport device for optically checking the correct placement of the filling blister in accordance with the prescription data.

Das Vordosiermagazin kann zur manuellen Zuführung eines Medikaments frei zugänglich ausgebildet sein. Dadurch können sehr selten benötigte Medikamente ohne Einbußen der Leistungsfähigkeit der Anlage manuell oder mit anderen Zuführtechniken zugeführt werden.The pre-metering magazine can be freely accessible for manual delivery of a drug. As a result, drugs that are rarely needed can be delivered manually or with other delivery techniques without sacrificing system performance.

Das erfindungsgemäße Verfahren weist vorzugsweise den Verfahrensschritt des Erstellens und Anfügens eines Dokumentationsträgers an den Befüllblister umfassend personenbezogene Information und/oder Anwendungsinformation zu den im Befüllblister verpackten Medikamenten auf.The method according to the invention preferably has the method step of creating and attaching a documentation carrier to the filling blister comprising personal information and / or application information to the medicaments packed in the filling blister.

Kurze Beschreibung der ZeichnungenBrief description of the drawings

Die Erfindung wird im Folgenden anhand von Ausführungsbeispielen unter Bezugnahme auf die Zeichnungen im Detail erläutert.

Figur 1
ist eine schematische Detailansicht von oben auf ein Ausführungsbeispiel einer erfindungsgemäßen Anlage zur personenindividuellen Bestückung von Befüllblistern.
Figur 2
zeigt ein Ausführungsbeispiel eines Befüllblisters zur Verwendung mit der erfindungsgemäßen Anlage.
Figur 3
ist eine schematische Detailansicht von oben zur Illustration des Verfahrensablaufs der Befüllung eines Befüllblisters gemäß einem Ausführungsbeispiel der Erfindung.
Figur 4
zeigt in Perspektivansicht ein Ausführungsbeispiel eines Vordosiermagazins der erfindungsgemäßen Anlage.
Figur 5
ist eine schematische Detail-Innenansicht eines Ausführungsbeispiels einer erfindungsgemäßen Medikamenten-Ausgabestation.
Figur 6
ist eine schematische Querschnittsansicht zur Illustration des Verfahrensablaufs der Befüllung eines Befüllblisters gemäß einem Ausführungsbeispiel der Erfindung.
Figur 7
ist ein Flussdiagramm zur Erläuterung der Verfahrensschritte eines Ausführungsbeispiels des erfindungsgemäßen Verfahrens zur personenindividuellen Bestückung von Befüllblistern.
Figur 8
ist eine schematische Darstellung eines Ausführungsbeispiels einer erfindungsgemäßen Anlage zur personenindividuellen Bestückung von Befüllblistern zur Erläuterung des Transports der Befüllblister in der Anlage.
The invention is explained in the following with reference to embodiments with reference to the drawings in detail.
FIG. 1
is a schematic detail view from above of an embodiment of a system according to the invention for personal placement of Befüllblistern.
FIG. 2
shows an embodiment of a Befüllblisters for use with the inventive system.
FIG. 3
is a schematic detail view from above to illustrate the process flow of filling a Befüllblisters according to an embodiment of the invention.
FIG. 4
shows in perspective view an embodiment of a pre-metering magazine of the system according to the invention.
FIG. 5
is a schematic detail interior view of an embodiment of a medicament dispensing station according to the invention.
FIG. 6
is a schematic cross-sectional view illustrating the process flow of filling a Befüllblisters according to an embodiment of the invention.
FIG. 7
is a flowchart for explaining the method steps of an embodiment of the method according to the invention for personal placement of Befüllblistern.
FIG. 8
is a schematic representation of an embodiment of a system according to the invention for personal placement of Befüllblistern to explain the transport of Befüllblister in the system.

Detaillierte Beschreibung der ErfindungDetailed description of the invention

Figur 1 zeigt in schematischer Draufsicht ein Befüllmodul 41 eines Ausführungsbeispiels der erfindungsgemäßen Anlage zur personenindividuellen Bestückung von Befüllblistern 25. Ein solches Befüllmodul 41 besteht in dem dargestellten Ausführungsbeispiel aus fünf hintereinander angeordneten Medikamenten-Befüllstationen 40, die jeweils zur Ausgabe von Dosiereinheiten eines bestimmten Medikamententyps vorgesehen sind. Die Anzahl der in einem Befüllmodul 41 zusammengefassten Medikamenten-Befüllstationen 40 ist selbstverständlich nicht auf fünf beschränkt, sondern kann je nach Platzverhältnissen oder Zweckmäßigkeit gewählt werden. Ebenso ist die Gesamtzahl der Medikamenten-Befüllmodule 41 der Anlage nicht auf eine bestimmte Anzahl eingeschränkt. Die Gesamtzahl der Befüllstationen 40 bestimmt dabei im Prinzip die maximale Anzahl der mit der Anlage verblisterbaren Medikamente, wobei für besonders häufig verwendete Medikamente auch mehr als eine Befüllstation vorgesehen sein kann. FIG. 1 shows in a schematic plan view of a filling module 41 of an embodiment of the inventive system for personal placement of Befüllblistern 25. Such Befüllmodul 41 consists in the illustrated embodiment of five consecutively arranged drug filling stations 40, which are each provided for dispensing of dosage units of a particular type of drug. The number of summarized in a Befüllmodul 41 medication filling stations 40 is of course not limited to five, but can be selected depending on space or convenience. Likewise, the total number of drug filling modules 41 of the plant is not limited to a certain number. In principle, the total number of filling stations 40 determines the maximum number of medicaments that can be blistered with the system, and more than one filling station can be provided for particularly frequently used medicaments.

Die erfindungsgemäße Anlage dient der personenindividuellen Bestückung von Befüllblistern mit Medikamenten entsprechend vorgegebenen Verschreibungsdaten für eine bestimmte Person/Patienten. Figur 2a zeigt ein Ausführungsbeispiel eines Befüllblisters 25 zur Verwendung mit der erfindungsgemäßen Anlage in Perspektivansicht und die Figuren 2b und 2c in Querschnittsansicht mit bzw. ohne Blisterfolie 27. Wie in Figur 2 schematisch dargestellt ist, weist der Befüllblister 25 in Matrixkonfiguration angeordnete Aufnahmefächer 26 auf, welche im gezeigten Ausführungsbeispiel in vier Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages (morgens, mittags, abends, nachts) und sieben Spalten entsprechend den Tagen einer Woche angeordnet sind. Die Erfindung ist jedoch nicht auf diese spezielle Anordnung der Aufnahmefächer 26 des Befüllblisters eingeschränkt.The system according to the invention is used for the personal placement of Befüllblistern with drugs according to predetermined prescription data for a specific person / patient. FIG. 2a shows an embodiment of a Befüllblisters 25 for use with the inventive plant in perspective view and the FIGS. 2b and 2c in cross-sectional view with or without blister foil 27. As in FIG. 2 is shown schematically, the Befüllblister 25 arranged in matrix configuration receptacles 26, which are arranged in the illustrated embodiment in four lines corresponding to a number of intake times during a day (morning, noon, evening, night) and seven columns corresponding to the days of a week. However, the invention is not limited to this particular arrangement of the receiving compartments 26 of the Befüllblisters.

Wiederum Bezug nehmend auf Figur 1 zeigt diese eine als Magnetschiene ausgebildete Führungsschiene 11 zum Transport der Befüllblister 25, die dabei auf einem Werkstückträger 20 (schematisch dargestellt in Figur 6) aufliegen. Vorzugsweise ist der Werkstückträger 20 dazu mit (nicht dargestellten) Mulden entsprechend der Anordnung der Aufnahmefächer 26 des Befüllblisters 25 versehen. Zu Beginn des Befüllvorgangs werden die Befüllblister 25 auf den Werkstückträger 20 aufgesetzt und durchlaufen einzeln und hintereinander den gesamten Weg von der ersten Befüllstation bis zur letzten Befüllstation der Bestückungsanlage. Jeder Befüllblister wird dabei einzeln angesteuert und stoppt lediglich an denjenigen Befüllstationen 40, an denen ein Medikamenten-Befüllvorgang in den jeweiligen Befüllblister 25 entsprechend den Verschreibungsdaten des jeweiligen Patienten erforderlich ist. Typischerweise stoppt ein Befüllblister 25 so an drei bis sieben Befüllstationen, an denen das jeweilige Medikament mittels eines Vordosiermagazins 50 zeilenweise zugeführt wird, wie unter Bezugnahme auf die Figuren 3 bis 6 später im Detail erläutert werden wird. Im Übergabebereich der Medikamente ist ein Reinraumbereich vorgesehen, der in Figur 1 schematisch mit 30 bezeichnet ist. Vorzugsweise wird in diesem Reinraumbereich 30 von der Decke her keimfreie und partikelarme Luft nach unten geblasen, die verhindert, dass Keime oder unerwünschte Staubpartikel in den geöffneten Befüllblister 25 gelangen.Referring again to FIG. 1 shows this designed as a magnetic rail guide rail 11 for transporting the Befüllblister 25, the case on a workpiece carrier 20 (shown schematically in FIG FIG. 6 ) rest. For this purpose, the workpiece carrier 20 is preferably provided with depressions (not shown) corresponding to the arrangement of the receiving compartments 26 of the filling blister 25. At the beginning of the filling operation, the Befüllblister 25 are placed on the workpiece carrier 20 and go through individually and in succession the entire way from the first filling station to the last filling of the assembly line. Each Befüllblister is controlled individually and stops only at those filling stations 40, where a drug filling process in the respective Befüllblister 25 is required according to the prescription data of each patient. Typically, a Befüllblister 25 stops at three to seven filling stations, where the respective drug by means of a pre-metering magazine 50 is supplied in rows, as with reference to the FIGS. 3 to 6 will be explained in detail later. In the transfer area of the drugs a clean room area is planned, which in FIG. 1 schematically designated 30. Preferably germ-free and particle-poor air is blown down from the ceiling in this clean room area 30, which prevents germs or undesired dust particles from entering the opened filling blister 25.

Hinter einem Befüllmodul 41 ist ein Fototunnel 32 mit einer (nicht dargestellten) Kamera vorgesehen, die ein optisches Bild des Befüllblisters 25 nach Durchlaufen des vorangehenden Befüllmoduls 41 erstellt. Mit Hilfe des durch die Kamera im Fototunnel 32 gewonnenen Bildes des Befüllblisters kann eine Auswertungselektronik überprüfen, ob die Medikamentenbestückung entsprechend den jeweiligen Patienten-Verschreibungsdaten korrekt ausgeführt wurde.Behind a filling module 41, a phototunnel 32 with a (not shown) camera is provided, which creates an optical image of the Befüllblisters 25 after passing through the previous Befüllmoduls 41. With the aid of the image of the filling blister obtained by the camera in the phototunnel 32, an evaluation electronics system can check whether the drug equipment was correctly executed in accordance with the respective patient prescription data.

Figur 4 illustriert schematisch in Aufsicht und Figur 6 in Querschnittsansicht den Medikamenten-Befüllvorgang an einer Medikamenten-Befüllstation 40. Zunächst wird das Befüllmodul 25 mit Hilfe des Werkstückträgers 20 zu dem vorgesehenen Medikamenten-Befüllmodul 40 befördert. Das Befüllmodul 20 stoppt seine Bewegung und das Vordosiermagazin 50 führt eine Bewegung senkrecht zur Bewegungsrichtung der Befüllblister aus, wie in den Figuren 6a und 6b mittels eines Pfeils angedeutet ist. Am Ende dieser Querbewegung befindet sich jeweils ein Vordosierfach 51 über einem Wochentagsfach 26 einer Zeile des Befüllblisters 25 (Figur 3a und Figur 6c). Dann wir ein Öffnungsmechanismus der Vordosierfächer 51 des Vordosiermagazins 50 aktiviert, so dass die in den Vordosierfächern 51 befindlichen Medikamente mit geringer Fallhöhe in die entsprechenden Fächer 26 des Befüllblisters 25 fallen. Der Öffnungsmechanismus des Vordosiermagazins ist bei dem dargestellten Ausführungsbeispiel der Erfindung als verschiebbarer Boden 55 des Vordosiermagazins ausgebildet. Andere Mechanismen wie etwa Klappmechanismen oder dgl. sind im Rahmen der Erfindung jedoch ebenfalls möglich. Wird das an der Ausgabestation 40 "verabreichte" Medikament 28 noch in einer anderen Tageszeitzeile des Befüllblisters 25 benötigt (beispielsweise für eine Medikamenteneinnahme morgens und abends) wird der Befüllblister in um die entsprechende Anzahl von Zeilen weitertransportiert und das Vordosiermagazin 50 fährt zurück (Figur 3d und Figur 6d), wird mit einer erneuten Portionierung der Medikamente versehen, die dann auf die gleiche Art und Weise in die weitere Tageszeitzeile des Befüllblisters 25 eingefüllt werden. Wenn der Bestückungsvorgang mit diesem bestimmten Medikament abgeschlossen ist, fährt der Befüllblister 25 zur nächsten vorgesehen Medikamenten-Befüllstation 40. FIG. 4 illustrated schematically in plan and FIG. 6 In a cross-sectional view of the drug filling process at a drug filling station 40. First, the filling module 25 by means of the workpiece carrier 20 to the provided Drug filling module 40 transported. The Befüllmodul 20 stops its movement and the pre-metering magazine 50 performs a movement perpendicular to the direction of movement of the Befüllblister, as in the Figures 6a and 6b indicated by an arrow. At the end of this transverse movement is in each case a predispensing compartment 51 over a weekday compartment 26 of a line of the Befüllblisters 25 (FIG. FIG. 3a and FIG. 6c ). Then, an opening mechanism of the pre-metering pockets 51 of the pre-metering magazine 50 is activated, so that the medicaments located in the pre-metering compartments 51 drop into the corresponding compartments 26 of the filling blister 25 at a low drop height. The opening mechanism of the pre-metering magazine is formed in the illustrated embodiment of the invention as a displaceable bottom 55 of the pre-metering magazine. However, other mechanisms such as folding mechanisms or the like are also possible within the scope of the invention. If the medicament 28 "administered" at the dispensing station 40 is still needed in another time line of the filling blister 25 (for example for a medication intake in the morning and in the evening), the filling blister is transported further in the corresponding number of lines and the pre-metering magazine 50 moves backward (FIG. 3d figure and FIG. 6d ), is provided with a new portioning of the drugs, which are then filled in the same manner in the other time line of the Befüllblisters 25. When the loading process is completed with this particular drug, the Befüllblister 25 moves to the next scheduled drug filling station 40th

Ein Ausführungsbeispiel eines Vordosiermagazins 50 ist in schematischer Perspektivansicht in Figur 4 gezeigt. Es sind insgesamt sieben Vordosierfächer 51 entsprechend den sieben Wochentagsspalten des Befüllblisters 25 vorgesehen, wobei erfindungsgemäß auch eine andere Anzahl an Fächern 51 möglich ist. Vorzugsweise sind die Vordosierfächer 51 in Form einer transparenten, zur Reinigungszwecken austauschbaren Innenverkleidung aus Kunststoff ausgebildet, die an einem vorzugsweise aus Metall ausgeführten stabilen Rahmenteil 54 befestigbar ist. Im unteren Bereich der Seitenwände der Vordosierfächer 51 sind beidseitig Schlitze 52 vorgesehen zur optischen Überprüfung, ob sich in dem jeweiligen Vordosierfach ein Medikament befindet oder nicht.An embodiment of a pre-metering magazine 50 is shown in schematic perspective view in FIG FIG. 4 shown. There are a total of seven Vordosierfächer 51 corresponding to the seven weekday columns of the Befüllblisters 25 is provided, according to the invention, a different number of compartments 51 is possible. Preferably, the predosing compartments 51 are in the form of a transparent plastic inner lining, which can be exchanged for cleaning purposes and can be fastened to a stable frame part 54, which is preferably made of metal. Slots 52 are provided on both sides in the lower region of the side walls of the predatory bins 51 for optically checking whether a medicament is or not present in the respective predosing bins.

Der Mechanismus zur Zuführung der Medikamente 28 in das Vordosiermagazin 50 einer Medikamenten-Befüllstation 40 ist schematisch in Figur 5 dargestellt. In dem gezeigten Ausführungsbeispiel wird das Medikament mittels eines Endlos-Streifenblisters 45 zugeführt, der äquidistant angeordnete Blisterhöfe 46 zur Aufnahme der Medikamentendosierungen aufweist, wobei der Abstand der einzelnen Blisterhöfe 46 des Streifenblisters 45 voneinander dem Abstand der Vordosierfächer 51 des Vordosiermagazins 50 entsprechen kann. Der in den jeweiligen Medikamenten-Befüllstationen 40 befindliche Streifenblister 45 wird vorzugsweise mit Hilfe eines (nicht dargestellten) Antriebsmechanismus von einer an sich bekannten Rolle abgerollt. Ist ein Streifenblister 45 aufgebraucht, so kann ohne Schwierigkeiten eine neue, gefüllte Streifenblisterrolle in der Medikamenten-Befüllstation 40 eingehängt werden und/oder der neue Streifenblister direkt an den vorhandenen Streifenblister angeklebt oder angeheftet werden, so dass eine unterbrechungsfreie Versorgung mit Medikamenten gewährleistet ist. Für sehr selten verschriebene Medikamente, für die sich eine Streifenverblisterung nicht lohnt, kann wenigstens eine Medikamenten-Befüllstation 40 zur manuellen Befüllung des Vordosiermagazins 50 vorgesehen sein. Dadurch wird es möglich, die Flexibilität der Anlage zu erhöhen und auch sehr selten verschriebene Medikamente zu wirtschaftlichen Bedingungen in die Verblisterung mit aufzunehmen.The mechanism for delivering the medication 28 into the pre-metering magazine 50 of a drug delivery station 40 is shown schematically in FIG FIG. 5 shown. In the exemplary embodiment shown, the medicament is supplied by means of an endless strip blister 45 which has equidistantly arranged blister stalls 46 for receiving the medicament dosages, wherein the spacing of the individual blister stalls 46 of the strip blister 45 from one another can correspond to the distance of the predispersing compartments 51 of the predosing magazines 50. The strip blister 45 located in the respective medication filling stations 40 is preferably unrolled from a roll known per se with the aid of a drive mechanism (not shown). If a strip blister 45 is used up, then a new, filled strip blister roll can be hung without difficulty in the medication filling station 40 and / or the new strip blister can be glued or adhered directly to the existing strip blister, so that an uninterrupted supply of medicaments is ensured. For very rarely prescribed drugs for which a strip blistering is not worthwhile, at least one medication filling station 40 for manual filling of the pre-metering magazine 50 may be provided. This makes it possible to increase the flexibility of the plant and to include very rarely prescribed drugs on economic conditions in the blistering.

Wie in Figur 5 dargestellt, weist jede Medikamenten-Befüllstation 40 Auswurfstößel 42 auf zum Ausstoßen der Medikamente 28 aus dem Streifenblister 45 in das Vordosiermagazin 50. Vorzugsweise sind die Auswurfstößel 42 in einer Anzahl entsprechend der Anzahl der Vordosierfächer 51 des Vordosiermagazins 50 zum zeitsparenden parallelen Ausstoßen der Medikamenteneinheiten vorgesehen; dies ist jedoch nicht unbedingt erforderlich, sondern ein sequenzielles Ausstoßen der Medikamente ist ebenso möglich.As in FIG. 5 Each medication filling station 40 has ejector plungers 42 for ejecting medicaments 28 from strip blister 45 into pre-metering magazine 50. Preferably, ejection plungers 42 are provided in a number corresponding to the number of predosounders 51 of predosing magazine 50 for time-saving parallel ejection of the medicament units; However, this is not absolutely necessary, but a sequential ejection of the drugs is also possible.

Vorzugsweise weist eine Medikamenten-Befüllstation 40 wenigstens zwei Sensorvorrichtungen 47, 48 zur Überprüfung der korrekten Medikamentenübergabe Streifenblister-Vordosiermagazin-Befüllblister auf. Eine erste Durchlichtkamera oder Lichtschranke 47 erfasst durch die an den Vordosierfächern 51 vorgesehenen Schlitze 52, ob sich während der Ausfahrbewegung des Vordosiermagazins 50 ein Medikament in dem entsprechenden Vordosierfach 51 befindet und ob es sich bei der späteren Einfahrbewegung nicht mehr darin befindet, wodurch die korrekte Abgabe der Medikamenteneinheiten in die entsprechenden Fächer des Befüllblisters validiert werden kann. Zusätzlich ist vorzugsweise eine Auflichtkamera 48 vorgesehen, die den Befüllzustand der Vordosierfächer 51 vor der Medikamentenübergabe an den Befüllblister und danach ebenfalls optisch validiert, entweder mittels Lichtreflexion oder als Durchlichtdetektor. In letzterem Fall muss der Boden des Vordosiermagazins 50 lichtdurchlässig ausgebildet sein.Preferably, a medication filling station 40 has at least two sensor devices 47, 48 for checking the correct transfer of medication to the blister pre-metering magazine filling blister. A first transmitted light camera or Photocell 47 detects, by means of the slits 52 provided on the predispersing compartments 51, whether there is a medicament in the corresponding predosing compartment 51 during the extension movement of the predosing magazine 50 and if it no longer lies therein during the later retracting movement, whereby the correct dispensing of the medicament units into the predispersing compartment corresponding compartments of the Befüllblisters can be validated. In addition, an incident-light camera 48 is preferably provided, which also optically validates the filling state of the predosing compartments 51 before the medicament is transferred to the filling blister and then either by means of light reflection or as a transmitted-light detector. In the latter case, the bottom of the pre-metering magazine 50 must be translucent.

Gegenüber dem aus der WO 2005 102 841 A1 bekannten Stand der Technik sorgt die Verwendung des Vordosiermagazins 50 bei der erfindungsgemäßen Bestückungsanlage dafür, dass der Ausstoßvorgang aus dem Streifenblister 45 und der Bestückungsvorgang des Befüllblisters 25 voneinander entkoppelt werden. Dadurch kann der für die Leistungsfähigkeit der Gesamtanlage zeitkritische Befüllvorgang des Befüllblisters 25 in Bezug auf Schnelligkeit optimiert werden, während für den mechanisch schwierig auszuführenden Ausstoßvorgang aus dem Streifenblister 45 mehr Zeit zur Verfügung steht, ohne die Leistungsfähigkeit der Gesamtanlage zu beeinträchtigen.Opposite that from the WO 2005 102 841 A1 known prior art, the use of the pre-metering magazine 50 in the placement system according to the invention ensures that the ejection process from the strip blister 45 and the loading process of the Befüllblisters 25 are decoupled from each other. As a result, the time-critical filling process of the filling blister 25 with respect to speed can be optimized for the performance of the overall system, while more time is available for the mechanically difficult ejection process from the strip blister 45 without impairing the performance of the overall system.

Zur Förderung der Werkstückträger 12 ist erfindungsgemäß vorzugsweise ein Magnetschienensystem 10 mit Linearmotorantrieb vorgesehen, welches es erlaubt, jeden Werkstückträger 20 und damit den darauf befindlichen Befüllblister 25 einzeln zu steuern. Das Magnetschienensystem 10 weist eine in sich geschlossene Führungsschiene 11 auf, die in Querschnittsansicht in Figur 6 gezeigt ist. Jeder Werkstückträger 20 weist ein Führungselement 12 auf, das die Führungsschiene 11 umgreift und auf an sich bekannte Art und Weise nach dem Prinzip eines Magnetschwebezuges berührungslos oder berührend (gleitend, rollend) in der Führungsschiene 11 geführt wird. Ein ebenfalls an sich bekannter elektrischer Linearmotor sorgt für den einzeln ansteuerbaren Antrieb der Werkstückträger 20 und damit der Befüllblister 25.To promote the workpiece carrier 12 according to the invention preferably a magnetic rail system 10 is provided with linear motor drive, which allows each workpiece carrier 20 and thus the Befüllblister 25 located thereon to control individually. The magnetic track system 10 has a self-contained guide rail 11, which in cross-sectional view in FIG. 6 is shown. Each workpiece carrier 20 has a guide element 12, which surrounds the guide rail 11 and is guided in a known manner according to the principle of a magnetic levitation train contactless or touching (sliding, rolling) in the guide rail 11. An electric linear motor, which is also known per se, provides the individually controllable drive of the workpiece carriers 20 and thus the filling blister 25.

Ein Ausführungsbeispiel des erfindungsgemäßen Verfahrens zur personenindividuellen Bestückung von Befüllblistern wird im Folgenden unter Bezugnahme auf die Figuren 7 und 8 erläutert.An embodiment of the method according to the invention for personal placement of Befüllblistern is hereinafter with reference to the FIGS. 7 and 8th explained.

Zu Beginn der Bestückungsstrecke vor dem ersten Befüllmodul 41 ist eine Befüllblister-Auflagestation 60 vorgesehen, die in Figur 8 schematisch angedeutet ist. Am Ende der Bestückungsstrecke ist entsprechend eine Befüllblister-Entnahmestation 61 angeordnet.At the beginning of the placement line in front of the first filling module 41, a Befüllblister-supporting station 60 is provided which in FIG. 8 is indicated schematically. At the end of the assembly line a Befüllblister removal station 61 is arranged accordingly.

In einem ersten Verfahrensschritt S2 (Figur 7) wird somit in der Befüllblister-Auflagestation 60 ein leerer Befüllblister 25 auf den Werkstückträger 20 gesetzt. Dann (oder gleichzeitig) werden in Verfahrensschritt S4 die anzufahrenden Befüllstationen bestimmt, in dem in Figur 8 gezeigten Ausführungsbeispiel sind dies die Stationen A, B und C. Für den betrachteten Befüllblister 25 wird nun in Verfahrensschritt S6 überprüft, ob der Transportweg zur nächsten anzufahrenden Befüllstation durch einen an einer dazwischenliegenden Befüllstation in einen Befüllvorgang verwickelten vorausfahrenden Befüllblister belegt ist oder nicht. Ist dies der Fall, so folgt bzw. wartet der betrachtete Befüllblister 25 dem vorausgehenden Befüllblister gemäß Verfahrensschritt S8. Ist der Weg zur nächsten anzufahrenden Befüllstation 40 hingegen frei, fährt der Befüllblister 25 gemäß Schritt S10 mit maximaler Transportgeschwindigkeit zur dieser nächsten Medikamenten-Befüllstation 40, wo in Verfahrensschritt S12 der Befüllvorgang ausgeführt wird. Die Verfahrensschritte S6 bis S12 wiederholen sich, bis in Schritt S14 festgestellt wird, dass die letzte vorgesehene Befüllstation erreicht ist. Dann wird in Verfahrensschritt S16 der Befüllblister an der Befüllblister-Entnahmestation 61 entnommen, der Befüllblister 25 mit der Blisterfolie 27 versiegelt und eine (nicht dargestellte) Informationskarte mit Patienten-Identifizierungsinformation sowie Verschreibungsinformation für den Patienten gedruckt und diese Informationskarte an den Blister angebracht. Schließlich ist der bestückte und mit Informationskarte versehene Befüllblister 25 fertig für den Versand (Schritt S20).In a first method step S2 ( FIG. 7 ) an empty Befüllblister 25 is thus placed on the workpiece carrier 20 in the Befüllblister-Auflagestation 60. Then (or simultaneously), the filling stations to be approached are determined in method step S4, in which in FIG. 8 shown embodiment, these are the stations A, B and C. For the considered Befüllblister 25 is now checked in step S6, whether the transport path to the next to be approached filling station is occupied by a at an intermediate filling station in a filling process involved Befüllenden Befüllblister or not. If this is the case, then the considered Befüllblister 25 follows or the previous Befüllblister according to step S8. If, on the other hand, the route to the next filling station 40 to be approached is free, the filling blister 25 moves according to step S10 at maximum transport speed to this next medication filling station 40, where the filling operation is carried out in method step S12. The method steps S6 to S12 are repeated until it is determined in step S14 that the last intended filling station has been reached. Then in step S16 the Befüllblister is removed from the Befüllblister-removal station 61, the Befüllblister 25 sealed with the blister 27 and printed (not shown) information card with patient identification information and prescription information for the patient and this information card attached to the blister. Finally, the filled and information card-filled blister 25 is ready for shipment (step S20).

Figur 8 zeigt schematisch die verschiedenen Bewegungszustände der Befüllblister. Bewegungszustand (1), illustriert durch ein schraffiertes Rechteck mit Pfeil, bezeichnet eine Fortbewegung mit Maximalgeschwindigkeit bis zum nächsten anzusteuernden Medikamenten-Befüllstation oder bis zu einer "Warteschlange" vorausfahrender Befüllblister, Bewegungszustand (2), illustriert durch ein ausgefülltes Rechteck, bezeichnet einen Befüllvorgang an einer Medikamenten-Befüllstation 40, Bewegungszustand (3), illustriert durch ein schraffiertes Rechteck ohne Pfeil, bezeichnet eine Fortbewegung des Befüllblisters in einer "Warteschlange" hinter einem vorausfahrenden Befüllblister, und Bewegungszustand (4), illustriert durch mit Kreuz versehenes Rechteck, bezeichnet die Rückfahrbewegung eines leeren Werkstückträgers 20 zur Befüllblister-Auflagestation 60. Da die Anzahl der von jedem einzelnen Blister anzusteuernden Befüllstationen im Verhältnis zur Gesamtzahl der Befüllstationen relativ gering ist, sind die mit Maximalgeschwindigkeit zurücklegbaren Strecken (Bewegungszustand (1)) relativ lang, so dass die Leistungsfähigkeit der Gesamtanlage im Vergleich zu einer Anlage mit taktweisem Betrieb wie in der WO 2005 102 841 A1 offenbart, erheblich verbessert werden kann. Dies gilt auch dann, wenn die Reihenfolge der einzelnen Befüllblister 25 nicht bezüglich der Verblisterung sondern in Bezug auf eine Versandreihenfolge oder Verpackungsreihenfolge an die Endabnehmer (Apotheken) optimiert ist. FIG. 8 shows schematically the different states of motion of the Befüllblister. Movement state (1), illustrated by a hatched rectangle with arrow, denotes a movement with maximum speed to the next drug filling station to be controlled or to a "queue" of preceding Befüllblister, movement state (2), illustrated by a filled rectangle, indicates a filling a drug delivery station 40, motion state (3), illustrated by a hatched rectangle with no arrow, indicates a movement of the inflation blister in a "queue" behind a preceding inflation blister, and motion state (4), illustrated by a canted rectangle, indicates the return movement an empty workpiece carrier 20 to the Befüllblister-Auflagestation 60. Since the number of each blister to be controlled by each filling stations in relation to the total number of filling stations is relatively low, the maximum speed zurücklegbaren distances (movement State (1)) relatively long, so that the performance of the entire system compared to a system with cyclical operation as in WO 2005 102 841 A1 disclosed, can be significantly improved. This also applies if the order of the individual Befüllblister 25 is not optimized with respect to the Blistering but with respect to a shipping order or packaging order to the end user (pharmacies).

Die Erfindung ermöglicht durch die Verwendung des zwischen dem Streifenblister 45 und dem Befüllblister 25 zwischengeschalteten Vordosiermagazins 50, den zeitkritischen Vorgang der Befüllung des Befüllblisters 25 von dem mechanisch schwierigen Vorgang des Ausstoßens der Medikamenteinheiten aus dem Streifenblister 45 zu entkoppeln und damit die Leistungsfähigkeit und Zuverlässigkeit des Verblisterungsvorgangs wesentlich zu erhöhen. Ferner erlaubt die Möglichkeit der manuellen Befüllung des Vordosiermagazins die wrtschaftlich sinnvolle Erstreckung der Verblisterung auch auf sehr selten verschriebene Medikamente.The invention allows for the time-critical process of filling the Befüllblisters 25 from the mechanically difficult process of ejecting the medicament units from the Streifenblister 45 by the use of the between the strip blister 45 and the Befüllblister 25 intermediate predosing 50, and thus the performance and reliability of the blistering process significantly increase. Furthermore, the possibility of manual filling of the pre-metering magazine allows the verbally meaningful extension of the blistering even on very rarely prescribed drugs.

Claims (14)

  1. Facility for person-specific assembly of blister packs (25) with medicaments in accordance with predetermined prescription data, wherein the blister packs (25) exhibit receiving compartments arranged in a matrix configuration in rows, corresponding to a number of intake-times during a day, and columns, corresponding to a number of days, for example days of the week, for respective medicament-administration units, comprising:
    a plurality of medicament-filling stations (40) arranged in succession for assembling the blister packs (25) with, respectively, a certain medicament, and
    a transport device (10) designed for transporting the blister packs (25) individually in succession in a direction of motion along the medicament-filling stations (40),
    wherein each medicament-filling station (40) exhibits a pre-metering magazine (50) capable of being moved between two positions, with several pre-metering compartments (51), which has been set up to receive the medicament, in a first position, in one or more of the pre-metering compartments (51), and to release the medicament, in a second position, from the pre-metering compartments (51) into corresponding receiving compartments (26) of the blister pack (25),
    characterised in that in each medicament-filling station (40) the medicament is supplied by means of a blister strip (45) and each medicament-filling station (40) exhibits one or more ejector rams (42) for ejecting the medicament from blister squares (46) of the blister strip (45) into the pre-metering compartments (51) of the pre-metering magazine (50),
    a clean-room region (30) has been provided in the region of transfer of the medicaments into the blister packs (25), and
    the blister packs (25) are sealed with blister foil (27) after being filled.
  2. Facility according to Claim 1, wherein the blister strip (45) is capable of being moved in a medicament-filling station (40) only in one direction.
  3. Facility according to one of Claims 1 to 2, wherein the pre-metering magazine (50) exhibits a base (55) which in the second position of said magazine is capable of being displaced in the transverse direction for the purpose of releasing the medicament into the receiving compartments (26) of the blister pack (25).
  4. Facility according to one of Claims 1 to 3, wherein the pre-metering compartments (51) of the pre-metering magazine (50) have been formed in a row in such a manner that in the second position they have respectively been arranged above the receiving compartments (26) of the blister pack (25) arranged in a line corresponding to a number of days (of the week).
  5. Facility according to one of the preceding claims, wherein each medicament-filling station (40) exhibits at least one sensor device (47, 48) for checking the correct reception of the medicament in the pre-metering compartments (51) of the pre-metering magazine (50) and/or for checking the correct release of the medicament into the receiving compartments (26) of the blister pack (25).
  6. Facility according to Claim 5, wherein the pre-metering magazine (50) exhibits, in the region of the rest position of a medicament, slots (52) arranged laterally in the pre-metering compartments (51), and a first sensor device (47) has been designed to detect optically, through the slots (52), a medicament in the pre-metering compartments (51) during a movement of the pre-metering magazine (50) from the first into the second position and conversely.
  7. Facility according to Claim 5 or 6, wherein the base of the pre-metering compartments (51) of the pre-metering magazine (50) is light-transmitting or light-reflecting, and a second sensor device (48) includes a camera for registering medicaments located on the bottom of the pre-metering compartments (51).
  8. Facility according to one of the preceding claims, wherein the pre-metering magazine (50) exhibits an interchangeable inner lining made of plastic.
  9. Facility according to one of the preceding claims, wherein the transport device (10) takes the form of a magnetic track with linear motor for propelling the blister packs (25).
  10. Facility according to one of the preceding claims, wherein the transport device (10) has been designed for transporting workpiece carriers (20), guided in a magnetic rail (11), for receiving the blister packs (25).
  11. Facility according to Claim 10, wherein the transport device (10) takes the form of a closed path on which the workpiece carriers (20) are conveyed in a closed circuit, whereby prior to assembly the blister packs (25) are placed onto the workpiece carriers (20) and are removed after the assembly process.
  12. Facility according to one of the preceding claims, further including a camera arranged above the transport device (10) for optical checking of the correct assembly of the blister packs (25) in accordance with the prescription data.
  13. Facility according to one of the preceding claims, wherein the pre-metering magazine (50) is freely accessible for the purpose of manual supply of a medicament into said magazine.
  14. Facility according to one of the preceding claims, exhibiting a device for creating and for attaching to the blister pack (25) a documentation carrier comprising personal information and/or usage information relating to the medicaments packaged in the blister pack (25).
EP13151166.9A 2013-01-14 2013-01-14 System for personalised filling of blister packs with medications according to specified prescription data Not-in-force EP2754615B1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP13151166.9A EP2754615B1 (en) 2013-01-14 2013-01-14 System for personalised filling of blister packs with medications according to specified prescription data
PCT/EP2014/050151 WO2014108402A1 (en) 2013-01-14 2014-01-07 Installation for individually tailored filling of blister packs with medication according to predetermined prescription data
CA2897748A CA2897748A1 (en) 2013-01-14 2014-01-07 Installation for individually tailored filling of blister packs with medication according to predetermined prescription data
CN201480004827.8A CN104918856B (en) 2013-01-14 2014-01-07 Device for individually filling blister packs with medication according to predetermined prescription data
US14/760,593 US20150353213A1 (en) 2013-01-14 2014-01-07 Installation for individually tailored filling of blister packs with medication according to predetermined prescription data

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EP13151166.9A EP2754615B1 (en) 2013-01-14 2013-01-14 System for personalised filling of blister packs with medications according to specified prescription data

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EP2754615A1 EP2754615A1 (en) 2014-07-16
EP2754615B1 true EP2754615B1 (en) 2015-07-29

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EP (1) EP2754615B1 (en)
CN (1) CN104918856B (en)
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WO2014108402A1 (en) 2014-07-17
EP2754615A1 (en) 2014-07-16
CA2897748A1 (en) 2014-07-17
CN104918856A (en) 2015-09-16
CN104918856B (en) 2017-03-29
US20150353213A1 (en) 2015-12-10

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