EP0998285A4 - ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a - Google Patents
ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1aInfo
- Publication number
- EP0998285A4 EP0998285A4 EP98930356A EP98930356A EP0998285A4 EP 0998285 A4 EP0998285 A4 EP 0998285A4 EP 98930356 A EP98930356 A EP 98930356A EP 98930356 A EP98930356 A EP 98930356A EP 0998285 A4 EP0998285 A4 EP 0998285A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- alpha
- receptor antagonists
- adrenergic receptor
- adrenergic
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4992197P | 1997-06-18 | 1997-06-18 | |
| US49921P | 1997-06-18 | ||
| GBGB9719392.4A GB9719392D0 (en) | 1997-09-11 | 1997-09-11 | Alpha la adrenergic receptor antagonists |
| GB9719392 | 1997-09-11 | ||
| PCT/US1998/012673 WO1998057641A1 (fr) | 1997-06-18 | 1998-06-17 | ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0998285A1 EP0998285A1 (fr) | 2000-05-10 |
| EP0998285A4 true EP0998285A4 (fr) | 2003-01-08 |
Family
ID=26312232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98930356A Withdrawn EP0998285A4 (fr) | 1997-06-18 | 1998-06-17 | ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0998285A4 (fr) |
| JP (1) | JP2002505684A (fr) |
| AU (1) | AU734892B2 (fr) |
| CA (1) | CA2293408A1 (fr) |
| WO (1) | WO1998057641A1 (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207444B1 (en) | 1997-08-05 | 2001-03-27 | Merck & Co., Inc. | Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease |
| US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| AU5234899A (en) | 1998-07-30 | 2000-02-21 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| US6228870B1 (en) | 1998-11-10 | 2001-05-08 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1a adrenoceptor antagonists |
| US6319932B1 (en) | 1998-11-10 | 2001-11-20 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1A adrenoceptor antagonists |
| US6358959B1 (en) | 1999-01-26 | 2002-03-19 | Merck & Co., Inc. | Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists |
| US6828460B2 (en) | 1999-03-22 | 2004-12-07 | Pfizer Inc. | Resorcinol derivatives |
| GB2355263A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355264A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355457A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355456A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
| GEP20115290B (en) | 2002-11-27 | 2011-09-26 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| UY32312A (es) | 2008-12-10 | 2010-06-30 | Janssen Pharmaceutica Nv | 4-azetidinil-1-heteroaril-ciclohexanol antagonistas del ccr2 |
| US20100267689A1 (en) | 2009-04-17 | 2010-10-21 | Xuqing Zhang | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
| ES2541607T3 (es) | 2009-04-17 | 2015-07-22 | Janssen Pharmaceutica Nv | Antagonistas de CCR2 de ciclohexano unido a 4-azetidinilo-1-heteroátomo |
| WO2011154431A1 (fr) | 2010-06-09 | 2011-12-15 | Janssen Pharmaceutica Nv | Dérivés de 5,6-dihydro-2h-[1,4]oxazin-3-ylamine utiles comme inhibiteurs de bêta-sécrétase (bace) |
| TW201211027A (en) | 2010-06-09 | 2012-03-16 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of CCR2 |
| MX2012014934A (es) * | 2010-06-17 | 2013-05-20 | Janssen Pharmaceutica Nv | Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2. |
| MX347912B (es) | 2010-12-22 | 2017-05-17 | Janssen Pharmaceutica Nv | Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8ilaminautiles como inhibidores de beta-secretasa (bace). |
| ES2534973T3 (es) | 2011-03-09 | 2015-04-30 | Janssen Pharmaceutica N.V. | Derivados de 3,4-dihidro-pirrolo[1,2-a]pirazin-1-ilamina útiles como inhibidores de beta-secretasa (BACE) |
| GB2511685A (en) | 2011-11-18 | 2014-09-10 | Heptares Therapeutics Ltd | Muscarinic m1 receptor agonists |
| KR102243133B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-6,7-디하이드로[1,2,3]트리아졸로[1,5-a]피라진 유도체 |
| WO2014198853A1 (fr) | 2013-06-12 | 2014-12-18 | Janssen Pharmaceutica Nv | Dérivés de 4-amino-6-phényl-5,6-dihydro-imidazo[1,5-a]pyrazine utilisés comme inhibiteurs de la bêta-sécrétase (bace) |
| EP3008067B1 (fr) | 2013-06-12 | 2017-03-29 | Janssen Pharmaceutica N.V. | Dérivés de 4-amino-6-phényl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h) -one comme inhibiteurs de bêta-sécrétase (bace) |
| GB201404922D0 (en) | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| JP2017538753A (ja) | 2014-12-18 | 2017-12-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ２，３，４，５−テトラヒドロピリジン−６−アミンおよび３，４−ジヒドロ−２Ｈ−ピロール−５−アミンの化合物のβセクレターゼ阻害剤 |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| US10259787B2 (en) | 2016-10-14 | 2019-04-16 | Heptares Therapeutics Limited | Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819961D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014846A1 (fr) * | 1994-11-16 | 1996-05-23 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines et leurs utilisations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049821A (en) * | 1976-05-12 | 1977-09-20 | A. H. Robins Company, Inc. | Method of treating allergy |
| US4109005A (en) * | 1977-05-11 | 1978-08-22 | A. H. Robins Company, Inc. | Method of increasing rate of gastric emptying with pyrrolidinylbenzamides |
| US4254135A (en) * | 1979-10-16 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Amino-4-hydroxypyrrolidines |
| US5124457A (en) * | 1986-05-21 | 1992-06-23 | Abbott Laboratories | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies |
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
-
1998
- 1998-06-17 WO PCT/US1998/012673 patent/WO1998057641A1/fr not_active Ceased
- 1998-06-17 AU AU79763/98A patent/AU734892B2/en not_active Ceased
- 1998-06-17 EP EP98930356A patent/EP0998285A4/fr not_active Withdrawn
- 1998-06-17 CA CA002293408A patent/CA2293408A1/fr not_active Abandoned
- 1998-06-17 JP JP50478199A patent/JP2002505684A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014846A1 (fr) * | 1994-11-16 | 1996-05-23 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines et leurs utilisations |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO9857641A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU7976398A (en) | 1999-01-04 |
| JP2002505684A (ja) | 2002-02-19 |
| CA2293408A1 (fr) | 1998-12-23 |
| AU734892B2 (en) | 2001-06-28 |
| EP0998285A1 (fr) | 2000-05-10 |
| WO1998057641A1 (fr) | 1998-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20000118 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20021125 |
|
| AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
| RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/445 A, 7A 61K 31/505 B, 7C 07D 211/18 B, 7C 07D 239/34 B, 7C 07D 491/08 B, 7C 07D 487/04 B, 7C 07D 401/12 B, 7C 07D 411/12 B, 7C 07D 413/12 B, 7C 07D 401/14 B, 7C 07D 403/12 B, 7C 07D 413/14 B, 7C 07D 403/14 B, 7A 61P 13/08 B |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20030103 |