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MX2012014934A - Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2. - Google Patents

Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2.

Info

Publication number
MX2012014934A
MX2012014934A MX2012014934A MX2012014934A MX2012014934A MX 2012014934 A MX2012014934 A MX 2012014934A MX 2012014934 A MX2012014934 A MX 2012014934A MX 2012014934 A MX2012014934 A MX 2012014934A MX 2012014934 A MX2012014934 A MX 2012014934A
Authority
MX
Mexico
Prior art keywords
sup
ccr2
cyclohexyl
syndrome
disorder
Prior art date
Application number
MX2012014934A
Other languages
English (en)
Inventor
Zhihua Sui
Nalin Subasinghe
Thomas P Markotan
James C Lanter
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2012014934A publication Critical patent/MX2012014934A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

La presente invención comprende compuestos de la Fórmula I en donde: R1, R2, R4, J, Q y A son como se definen en la especificación; la presente invención comprende, además, un método para prevenir, tratar o mejorar un síndrome, trastorno o enfermedad, en donde el síndrome, trastorno o enfermedad es diabetes tipo II, obesidad y asma; la presente invención comprende, además, un método para inhibir la actividad del CCR2 en un mamífero mediante la administración de una cantidad de eficacia terapéutica de por lo menos un compuesto de la Fórmula I.
MX2012014934A 2010-06-17 2011-06-16 Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2. MX2012014934A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35566310P 2010-06-17 2010-06-17
PCT/US2011/040610 WO2011159854A1 (en) 2010-06-17 2011-06-16 Cyclohexyl-azetidinyl antagonists of ccr2

Publications (1)

Publication Number Publication Date
MX2012014934A true MX2012014934A (es) 2013-05-20

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MX2012014934A MX2012014934A (es) 2010-06-17 2011-06-16 Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2.

Country Status (13)

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US (2) US8518969B2 (es)
EP (1) EP2582692B1 (es)
JP (1) JP5936608B2 (es)
KR (1) KR101743280B1 (es)
CN (1) CN103097375B (es)
AR (1) AR082016A1 (es)
AU (1) AU2011268375B2 (es)
BR (1) BR112012031873A2 (es)
CA (1) CA2801934A1 (es)
ES (1) ES2550312T3 (es)
MX (1) MX2012014934A (es)
TW (1) TW201204717A (es)
WO (1) WO2011159854A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120083447A1 (en) 2009-04-30 2012-04-05 Midwestern University Novel Therapeutic Treatments Using Centhaquin
CN102850200B (zh) * 2012-09-11 2015-09-30 西安彩晶光电科技股份有限公司 一种工业化生产4-羟基环己酮的方法
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